2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. Suvemcitug

Suvemcitug  (Synonyms: APX-003; BD-0801)

Cat. No.: HY-P990082 Purity: 96%
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Suvemcitug is a humanized IgG1κ antibody targeting VEGF with antiangiogenic activity. Suvemcitug selectively binds to and blocks VEGFA from binding to VEGFR1 and 2, thereby inhibiting its activities and preventing tumor angiogenesis and ultimately suppressing tumor growth and metastasis. Suvemcitug can be used for the study of colorectal cancer.

For research use only. We do not sell to patients.

CAS No. : 1610010-57-5

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Based on 1 publication(s) in Google Scholar

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Description

Suvemcitug is a humanized IgG1κ antibody targeting VEGF with antiangiogenic activity. Suvemcitug selectively binds to and blocks VEGFA from binding to VEGFR1 and 2, thereby inhibiting its activities and preventing tumor angiogenesis and ultimately suppressing tumor growth and metastasis. Suvemcitug can be used for the study of colorectal cancer[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

VEGFA
Clinical Trial
Gene ID

7422  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

145.782 kDa

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Suvemcitug]
Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Loaded Suvemcitug on ProA biosensor, can bind HY-P7420 VEGF121 Protein, Human (120a.a) with an affinity constant of 3.500E-11 M as determined in BLI assay.
Purity & Documentation
References
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Suvemcitug Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Suvemcitug1610010-57-5APX-003 BD-0801APX003APX 003BD0801BD 0801BD-0801VEGFRVascular endothelial growth factor receptorInhibitorinhibitorinhibit

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