347 Results for "

reference

" in MedChemExpress (MCE) Product Catalog:
Products (347)

347 Results for "reference" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-P99364
CAS No.: 1024603-92-6
Synonyms: Anti-VEGFR1/FLT1 reference Antibody; IMC-18F1

Target:  

VEGFR Apoptosis p38 MAPK Akt

Research Areas:  

Endocrinology Cancer

Icrucumab (Anti-VEGFR1/FLT1 Reference Antibody; IMC-18F1) is an IgG1 antibody inhibitor targeting VEGFR-1/FLT1 with anti-tumor activity. By blocking ligand-dependent phosphorylation and downstream signal transduction, Icrucumab reduces the activities of MAPK and Akt in breast cancer xenograft models, inhibits the proliferation and invasion of VEGFR-1-positive tumor cells, and reverses the conversion of M1 macrophages to the pro-tumor M2-like phenotype. Icrucumab also inhibits tumor cell proliferation, promotes apoptosis, and effectively suppresses tumor growth through direct targeting of tumors and host support mechanisms. In addition, Icrucumab exhibits a synergistic effect when combined with chemotherapeutic agents, and it is used in research related to various cancers including advanced solid malignancies, thyroid cancer, melanoma, and lung cancer .
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1 Cited Publications
Cat. No.: HY-P99376
CAS No.: 2108782-45-0
Synonyms: OMS 721; Anti-MASP2 reference Antibody (narsoplimab)

Target:  

SARS-CoV

Research Areas:  

Infection

Narsoplimab (OMS 721) is a high-affinity fully human immunoglobulin gamma 4 (IgG4) monoclonal antibody that binds MASP-2 and blocks lectin pathway activation. Narsoplimab can be used in research of hematopoietic stem-cell transplantation and SARS-CoV-2 .
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1 Cited Publications
Cat. No.: HY-P99370
CAS No.: 1391726-30-9
Synonyms: LY2495655; Anti-GDF8 / Myostatin reference Antibody (landogrozumab)

Target:  

TGF-beta/Smad

Research Areas:  

Inflammation/Immunology Cancer

Landogrozumab (LY2495655) is an humanized anti-myostatin monoclonal antibody. Landogrozumab effectively improves muscle volume, hand grip strength and function. Landogrozumab can be used for the research of muscle wasting disease .
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1 Cited Publications
Cat. No.: HY-P99374
CAS No.: 1622327-39-2
Synonyms: Anti-TSPAN26/CD37 reference Antibody (naratuximab)

Target:  

ADC Antibodies

Research Areas:  

Cancer

Naratuximab (Anti-TSPAN26/CD37 Reference Antibody (naratuximab)) is a humanized monoclonal antibody that binds CD37 (TSPAN26). Naratuximab can be used to synthesize an ADC compound, Naratuximab emtansine .
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1 Cited Publications
Cat. No.: HY-D0043
CAS No.: 198978-94-8
Synonyms: 5(6)-Carboxy-X-rhodamine
5(6)-ROX (5(6)-Carboxy-X-rhodamine) is a nucleic acid fluorescent label which can be used as a reference dye for real-time polymerase chain reaction (Em/Ex = 605/585 nm) .
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1 Cited Publications
Cat. No.: HY-13231
CAS No.: 1415559-43-1
Purity:  98.52%
Target:  

CDK HIV

Research Areas:  

Infection

CDK9-IN-1 is a novel, selective CDK9 inhibitor for the treatment of HIV infection, with an IC50 of 39 nM for CDK9/CycT1, extracted from reference, compound 87.
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1 Cited Publications
Cat. No.: HY-P990572

Research Areas:  

Inflammation/Immunology

DCBY02 is a monoclonal antibody targeting CD93 expressed in CHO cells. DCBY02 has a heavy chain of the mlgG type and a light chain of the mkappa type, with a predicted molecular weight (MW) of 150 kDa. The isotype control for DCBY02 can be referenced as Mouse IgG1 kappa, Isotype Control.
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1 Cited Publications
Cat. No.: HY-141749B
CAS No.: 144750-42-5
Purity:  99.50%
Synonyms: CLPM hydrochloride; SR 26334 hydrochloride
Target:  

Drug Metabolite

Research Areas:  

Cardiovascular Disease

Clopidogrel carboxylic acid (CLPM) hydrochloride is an inactive metabolite of the widely used antiplatelet medication clopidogrel, which serves as a reference standard for quantitative analysis of clopidogrel metabolism. Clopidogrel carboxylic acid hydrochloride has been shown to represent approximately 85% of circulating clopidogrel, hydrolyzed from the active form by esterases. Clopidogrel carboxylic acid hydrochloride plays a crucial role in assessing the pharmacokinetics and bioavailability of clopidogrel in various clinical and research settings.
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1 Cited Publications
Cat. No.: HY-D1565
CAS No.: 2270866-73-2
Cy7.5 maleimide is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis . CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance .
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Cat. No.: HY-P99372
CAS No.: 339306-30-8
Synonyms: Anti-NCAM1/ CD56 reference Antibody (lorvotuzumab)

Target:  

ADC Antibodies

Research Areas:  

Cancer

Lorvotuzumab (Anti-NCAM1/CD56 Reference Antibody (lorvotuzumab)) is a humanized monoclonal antibody that binds CD56 (NCAM1). Lorvotuzumab can be used to synthesize an ADC compound, Lorvotuzumab mertansine .
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Cat. No.: HY-P99361
CAS No.: 1062149-33-0
Synonyms: PDL192; ABT-361; Anti-TNFRSF12A/TWEAKR/CD266 reference Antibody (enavatuzumab)

Target:  

TNF Receptor

Research Areas:  

Cancer

Enavatuzumab (PDL192; ABT-361) is a humanized IgG1 monoclonal antibody targeting the receptor of TNF-like weak inducer of apoptosis (TWEAK). TWEAK (Fn14; TNFRSF12A), the natural ligand of the TWEAK receptor (TweakR), stimulates multiple cellular responses. Enavatuzumab induces tumor growth inhibition through direct TweakR signaling and antibody dependent cell-mediated cytotoxicity (ADCC). Enavatuzumab can actively recruits and activates myeloid effectors to kill tumor cells. Enavatuzumab inhibits the growth of various human TweakR-positive cancer cell lines and xenografts in vitro and in vivo .
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Cat. No.: HY-W116335A
CAS No.: 21645-51-2
Dried aluminum hydroxide gel, United States Pharmacopeia (USP) Reference Standard is a commonly used antacid with remarkable compound adhesion and release activity. Dried aluminum hydroxide gel, United States Pharmacopeia (USP) Reference Standard can effectively neutralize gastric acid and relieve stomach discomfort. Dried aluminum hydroxide gel, United States Pharmacopeia (USP) Reference Standard is also often used as an adjuvant in vaccines to enhance immune responses. Dried aluminum hydroxide gel, United States Pharmacopeia (USP) Reference Standard can improve the stability and bioavailability of compounds in preparations .
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Cat. No.: HY-P99351
CAS No.: 1518996-49-0
Synonyms: Anti-MMP9 reference Antibody (andecaliximab)

Target:  

MMP

Research Areas:  

Cancer

Andecaliximab is a recombinant chimeric IgG4 monoclonal antibody (mAb) targets matrix metalloproteinase 9 (MMP9). Andecaliximab shows the antifibrotic efficacy in idiopathic pulmonary fibrosis mouse models. Andecaliximab can be used for the research of gastric adenocarcinoma and idiopathic pulmonary fibrosis (IPF) .
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Cat. No.: HY-P99379
CAS No.: 2171061-85-9
Synonyms: CAN04; Anti-IL-1RAP/IL-1R3 reference Antibody (nidanilimab)

Target:  

Interleukin Related

Research Areas:  

Cancer

Nidanilimab (CAN04) is a fully humanized monoclonal anti-IL1RAP antibody with a Kd value of 1.10 pM. Nidanilimab blocks IL1α and IL1β signaling and stimulates the immune system to destroy tumour cells. Nidanilimab can be used in research of non-small lung cancer (NSCLC) and pancreatic ductal adenocarcinoma (PDAC) .
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Cat. No.: HY-P99357
CAS No.: 1452387-69-7
Synonyms: REGN1193; Anti-GCGR reference Antibody (crotedumab)

Target:  

GCGR

Research Areas:  

Metabolic Disease

Crotedumab (REGN1193) is a fully human IgG4 monoclonal antibody that binds and inhibits glucagon receptor (GCGR), with a KD of 0.1 nM. Crotedumab can be used for the research of diabetes .
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Cat. No.: HY-P99356
CAS No.: 2094516-02-4
Synonyms: BIIB054; Anti-Alpha-synuclein reference Antibody (cinpanemab)

Target:  

α-synuclein

Research Areas:  

Neurological Disease

Cinpanemab (BIIB054) is a human-derived monoclonal antibody that binds to α-synuclein. Cinpanemab can be used for the research of Parkinson's disease .
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Cat. No.: HY-P99363
CAS No.: 2252518-85-5
Synonyms: Anti-ICOS/CD278 reference Antibody (feladilimab); GSK3359609

Research Areas:  

Cancer

Feladilimab (Anti-ICOS/CD278 Reference Antibody (feladilimab); GSK3359609) is humanized IgG4 anti-ICOS/CD278 agonist monoclonal antibody. Feladilimab can be used for the research of cancer .
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Cat. No.: HY-148436
CAS No.: 2166376-64-1
Purity:  98.99%
Glucocorticoid receptor agonist-2 Ala-Ala-Mal (compound 79) can be used to synthesize anti-inflammatory ADC molecules. Glucocorticoid receptor agonist-2 is an active reference for ABBV-3373 .
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Cat. No.: HY-148676
CAS No.: 2440018-29-9
Purity:  96.22%
Synonyms: DS-1594a; Menin-MLL inhibitor 26
Research Areas:  

Cancer

Emilumenib (Menin-MLL inhibitor 26) is an orally active Menin-MLL inhibitor. Emilumenib also is an active reference. Emilumenib can inhibits cell growth. Emilumenib can be used for the research of leukemia .
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Cat. No.: HY-P99377
CAS No.: 1638338-43-8
Synonyms: OMP-305B83; Anti-DLL4 reference Antibody (navicixizumab)

Target:  

Notch

Research Areas:  

Cancer

Navicixizumab (OMP-305B83) is a bispecific anti-VEGF and anti-DLL4 inhibitory antibody. Navicixizumab can combine with Paclitaxel (HY-B0015) for cancer research. Navicixizumab can be used in the research of ovarian, primary peritoneal, or fallopian tube cancer .
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