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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
744 Results for "
AF
" in MedChemExpress (MCE) Product Catalog:
Products (744)
744 Results for "AF" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-P75232
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: EFNA5; LERK-7; Prev. EPLG7; Alternative Protein EFNA5; EPH-Related Receptor Tyrosine Kinase Ligand 7; GLC1M; LERK7; EFL5; Ephrin-A5; RAGS; AF1; Ephrin A5; AL-1
Species:
Mouse
Source:
HEK293
Cat. No.: HY-D2381
Cat. No.: HY-D2166
Cat. No.: HY-174873
Target:
Research Areas:
AF151 is a METTL3 PROTAC degrader with the DC50 of 0.43 μM in MOLM-13 cells. AF151 inhibits cell growth by significantly degrading METTL3 protein and reducing m6A levels. AF151 can induce cell apoptosis and reduce the level of Bcl-2 protein. AF151 can be used for research on cancer such as acute myeloid leukemia (AML). (Pink: METTL3 Ligand (HY-174874); Blue: VHL Ligand (HY-125845); Black: Linker; VHL Ligand+Linker (HY-174875)) .
Cat. No.: HY-171180
CAS No.: 122510-61-6
Target:
Research Areas:
AF615 is a small molecule inhibitor targeting the CDT1/Geminin protein complex (IC50 = 0.313 μM). AF615 selectively induces DNA damage, inhibits DNA synthesis, causes cell cycle arrest, and decreases the survival rate in cancer cell lines. AF615 displayed a Ki = 0.37 μM in case of Geminin-tCDT1 interaction and a Ki = 0.75 μM in case of Geminin-miniCDT1 interaction .
Cat. No.: HY-D2171
Cat. No.: HY-D2178
Cat. No.: HY-D2161A
Cat. No.: HY-116586
Target:
Research Areas:
AF710B is an orally effective allosteric agonist for the M1 muscarinic receptor and σ1 receptor. AF710B activates the downstream phosphorylated ERK1/2 and phosphorylated CREB signaling pathways. AF710B simultaneously improves cognitive function and alleviates the core pathological features of Alzheimer's disease, including Aβ deposition, excessive Tau phosphorylation and neuroinflammation. AF710B is applicable to the research of Alzheimer's disease .
Cat. No.: HY-D2170
Cat. No.: HY-D2445
CAS No.: 852953-60-7
Cat. No.: HY-D2167
Cat. No.: HY-N3430
CAS No.: 16274-11-6
Synonyms: AF33
Target:
Cat. No.: HY-D2176
Cat. No.: HY-D2154
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
