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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
61 Results for "
ASK1
" in MedChemExpress (MCE) Product Catalog:
Products (61)
61 Results for "ASK1" in MCE Product Catalog:
Cat. No.: HY-183766
Research Areas:
HYF038 is a blood-brain barrier-penetrant ligand of apoptosis signal-regulating kinase 1 (ASK1). When labeled with 11C, HYF038 can be used for ASK1 neuroimaging studies [1].
Cat. No.: HY-183933
CAS No.: 1355228-39-5
Target:
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K812 is an orally active ASK1 inhibitor with a 6 nM IC50 against ASK1. K812 selectively inhibits ASK1 activation. K812 inhibits glial activation in the lumbar spinal cord. K812 extends survival of SOD1 G93A transgenic mice. K812 can be used for the research of amyotrophic lateral sclerosis [1].
Cat. No.: HY-N1508R
CAS No.: 78285-90-2
Category:
Cat. No.: HY-183960
CAS No.: 890601-68-0
Target:
Research Areas:
BPyO-34 is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 0.52 μM against human targets. BPyO-34 inhibits the activity of ASK1 in in vitro kinase assays. BPyO-34 can be used in research related to various diseases such as diabetes and cancer [1].
Cat. No.: HY-P701705
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAP3K5; MEK Kinase 5; Prev. MEKK5; ASK-1; MAPKKK5; Mitogen-Activated Protein Kinase Kinase Kinase; ASK1; Apoptosis Signal Regulating Kinase 1; Apoptosis Signal-Regulating Kinase 1; MAP/ERK Kinase Kinase 5; MAPK/ERK Kinase Kinase 5; Mitogen-Activated Protein Kinase Kinase Kinase 5; MEKK 5
Species:
Human
Source:
E. coli
Synonyms: α-N-Acetyl-L-glutamine (Standard); N2-Acetylglutamine (Standard)
Target:
Cat. No.: HY-182324
CAS No.: 3085154-16-8
Research Areas:
TrxR2-IN-1 is a thioredoxin reductase 2 (TrxR2) inhibitor with an IC50 value of 0.83 μM. TrxR2-IN-1 accumulates in mitochondria, impairs mitochondrial function and membrane potential, increases reactive oxygen species (ROS) levels, activates ASK1-mediated caspase-dependent apoptosis (apoptosis), induces G2/M cell cycle arrest, and inhibits cancer cell migration. TrxR2-IN-1 can be used in the research of hepatocellular carcinoma [1].
Cat. No.: HY-103258R
CAS No.: 1005775-56-3
Target:
Research Areas:
TC ASK 10 (Standard) is the analytical standard of TC ASK 10 (HY-103258). This product is intended for research and analytical applications. TC ASK 10 (Compound 10) is a potent, selective and orally active apoptosis signal-regulating kinase 1 (ASK1) inhibitor with an IC50 of 14 nM. The inhibitory activities of TC ASK 10 towards other representative panel of kinases are less than 50%, except for ASK2 (IC50 of 0.51 μM) [1].
Cat. No.: HY-RS08060
Target:
Research Areas:
Map3k5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Map3k5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-182648
CAS No.: 1355228-38-4
Target:
Research Areas:
K811 is an orally active ASK1 inhibitor with an IC50 of 6 nM. K811 inhibits glial cell activation in the lumbar spinal cord of SOD1 G93A transgenic mice. K811 extends the survival of SOD1 G93A transgenic mice, a mouse model of amyotrophic lateral sclerosis. K811 can be used in studies related to amyotrophic lateral sclerosis [1].
Cat. No.: HY-RS08058
Target:
Research Areas:
MAP3K5 Human Pre-designed siRNA Set A contains three designed siRNAs for MAP3K5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS08059
Target:
Research Areas:
Map3k5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Map3k5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-100844R
CAS No.: 1262041-49-5
Target:
Research Areas:
GS-444217 (Standard) is the analytical standard of GS-444217 (HY-100844). This product is intended for research and analytical applications. GS-444217 is a potent, orally available and selective ATP-competitive inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 of 2.87 nM [1].
Cat. No.: HY-188099
CAS No.: 2376783-79-6
CeY-B1 is a ceramide analog. CeY-B1 inhibits the proliferation, migration and invasion of cervical cancer cells, induces apoptosis and cell cycle arrest. CeY-B1 upregulates ASK1, promotes the phosphorylation of JNK, downregulates Bcl‑2, and inhibits the PI3K/AKT pathway. CeY-B1 suppresses tumor growth in cervical cancer xenograft mouse models. CeY-B1 can be used for relevant research on cervical cancer [1].
Cat. No.: HY-182071
CAS No.: 2349329-01-5
Target:
Research Areas:
MG16 is a prodrug of 10-Methoxycamptothecin (HY-N0446). MG16 downregulates CDK6 and upregulates ASK1. MG16 induces cell cycle arrest and Apoptosis. MG16 exhibits anticancer activity against Lewis lung carcinoma, small cell lung cancer, and non-small cell lung cancer [1].
Cat. No.: HY-174863
CAS No.: 2376050-06-3
Research Areas:
Pomalidomide-C2-PEG-NHCO-C2-COOH is a conjugate of the CRBN ligand (HY-10984) and the linker (E3 Ligase Ligand-Linker Conjugate). Pomalidomide-C2-PEG-NHCO-C2-COOH can be used for synthesizing PROTAC ASK1 degrader dASK1 (HY-174862) [1].
Cat. No.: HY-W259575
CAS No.: 70035-83-5
CDKi free base is a CDK inhibitor. CDKi free base induces morphological changes, DNA fragmentation, and cell death in vestibular schwannoma cells. CDKi free base downregulates pRb, EGF-R, PI3K, NF-κB, and Shh levels, while upregulating JNK, ASK1, Caspase 3, and p21, and induces PARP-1 cleavage. CDKi free base can be used in research related to vestibular schwannoma [1].
Cat. No.: HY-P2961A
Target:
Research Areas:
Glutathione-S-Transferase, Rat is a glutathione S-transferase derived from the rat. Glutathione-S-Transferase, Rat is a phase II metabolic enzyme composed of three superfamilies: cytosolic, mitochondrial, and microsomal. Glutathione-S-Transferase, Rat possesses multiple catalytic activities, including catalytic detoxification and thiol transfer, as well as molecular chaperone functions. The Glutathione-S-Transferase, Rat isoform GSTP1 is highly expressed in malignant tumors and serves as a tumor biomarker [1] .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
