2. Apoptosis
  3. ASK1
  4. HYF038

HYF038 is a blood-brain barrier-penetrant ligand of apoptosis signal-regulating kinase 1 (ASK1). When labeled with 11C, HYF038 can be used for ASK1 neuroimaging studies.

For research use only. We do not sell to patients.

HYF038

HYF038 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

HYF038 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

HYF038 is a blood-brain barrier-penetrant ligand of apoptosis signal-regulating kinase 1 (ASK1). When labeled with 11C, HYF038 can be used for ASK1 neuroimaging studies[1].

In Vivo

[11C]HYF038 (0.04-0.4 mg/kg; intravenous injection via tail vein; single administration) exhibits a certain degree of BBB penetration, but shows low uptake; the high-dose blocking group presents a relatively high initial brain SUV followed by rapid washout[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (male, 6 months old)[1]
Dosage: 0.04 mg/kg; 0.4 mg/kg
Administration: i.v.; single dose 5 minutes pre-[11C]HYF038
Result: Showed [11C]HYF038 brain uptake similar to baseline animals at 0.04 mg/kg dose.
Revealed a blocking effect in the 0.04 mg/kg dose group via normalized brain time-activity curves.
Demonstrated an initial [11C]HYF038 brain uptake peak SUV of 1.3 followed by rapid washout at 0.4 mg/kg dose.
Molecular Weight

410.33

Formula

C17H14F4N6O2
SMILES

FC1=CN(C)C(C(C(NC2=NC(C3=NN=CN3[C@@H](C)C(F)(F)F)=CC=C2)=O)=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

HYF038 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HYF038HYF 038HYF-038ASK1Apoptosis signal-regulating kinase 1MAP3K5MAPKKK5Mitogen-activated protein kinase kinase kinase 5MEK kinase 5Apoptosis signal regulating kinase 1livermouse brain regionsblood-brain barrierneurodegenerative diseasesInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
HYF038
Cat. No.:
HY-183766
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.