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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
67 Results for "
B-Raf kinase
" in MedChemExpress (MCE) Product Catalog:
Products (67)
67 Results for "B-Raf kinase" in MCE Product Catalog:
Cat. No.: HY-10320R
CAS No.: 285983-48-4
Synonyms: BIRB 796 (Standard)
Target:
Research Areas:
Doramapimod (Standard) is the analytical standard of Doramapimod. This product is intended for research and analytical applications. Doramapimod (BIRB 796) is an orally active, highly potent p38 MAPK inhibitor, which has an IC50 for p38α=38 nM, for p38β=65 nM, for p38γ=200 nM, and for p38δ=520 nM. Doramapimod has picomolar affinity for p38 kinase (Kd=0.1 nM). Doramapimod also inhibits B-Raf with an IC50 of 83 nM .
Cat. No.: HY-146492
VEGFR-2/BRAF-IN-2 (Compound 4a) is a dual VEGFR-2 and BRAF kinases inhibitor with IC50 values of 0.111, 0.089 and 0.071 µM against VEGFR-2, BRAF V600E and BRAF WT, respectively. VEGFR-2/BRAF-IN-2 induces apoptosis and arrests the cell cycle mainly in the G1 phase .
Cat. No.: HY-146491
VEGFR-2/BRAF-IN-1 (Compound 4b) is a dual VEGFR-2 and BRAF kinases inhibitor with IC50 values of 0.049, 0.063 and 0.005 µM against VEGFR-2, BRAF V600E and BRAF WT, respectively. VEGFR-2/BRAF-IN-1 induces apoptosis and arrests the cell cycle mainly in the G1/S phase .
Cat. No.: HY-164530
CAS No.: 1970149-05-3
SKLB646 is an orally active multi-target kinase inhibitor. SKLB646 shows significant inhibitory effects on SRC and VEGFR2 with IC50 values ??of 0.002 μmol/L and 0.012 μmol/L, respectively. SKLB646 also shows significant inhibitory effects on B-Raf and C-Raf with IC50 values ??of 0.022 μmol/L and 0.019 μmol/L, respectively. SKLB646 inhibits the activation of the SRC signaling pathway and blocks the MAPK signaling pathway by inhibiting Raf kinase. In addition, SKLB646 can inhibit the proliferation, migration and invasion of human umbilical vein endothelial cells (HUVEC) to inhibit tumor-induced angiopoietic formation. SKLB646 shows significant anti-proliferative and anti-survival activities against triple-negative breast cancer (TNBC) cell lines .
Cat. No.: HY-L196
4,585 compounds
Protein Kinases (PTKs) are a class of phosphotransferases that phosphorylate proteins. Protein kinases participate in many signal transduction pathways including those involved with growth, differentiation, and cell division. Protein kinase not only plays an important role in the process of cell activation, but also its abnormal expression is closely related to the pathogenesis of many diseases. So far, the protein kinase family has become one of the most important drug targets. The most common drug targets include ALK, B-Raf, BCR-Abl, EGFR, and VEGFR.
MCE designs a unique collection of 4,585 bioactive compounds targeting protein kinases, which is an important tool for the development of drug targeting protein kinases.
Cat. No.: HY-P703549
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: BRaf; V-Raf Murine Sarcoma Viral Oncogene-Like Protein B1; B-Raf Proto-Oncogene, Serine/Threonine kinase; Murine Sarcoma Viral (V-Raf) Oncogene Homolog B1; BRaf1; Serine/Threonine-Protein kinase B-Raf Variant; BRaf-1; Non-Specific Serine/Threonine Protein
Species:
Human
Source:
E. coli
Cat. No.: HY-P702921
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: BRaf; V-Raf Murine Sarcoma Viral Oncogene-Like Protein B1; B-Raf Proto-Oncogene, Serine/Threonine kinase; Murine Sarcoma Viral (V-Raf) Oncogene Homolog B1; BRaf1; Serine/Threonine-Protein kinase B-Raf Variant; BRaf-1; Non-Specific Serine/Threonine Protein
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P705999
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: BRaf; V-Raf Murine Sarcoma Viral Oncogene-Like Protein B1; B-Raf Proto-Oncogene, Serine/Threonine kinase; Murine Sarcoma Viral (V-Raf) Oncogene Homolog B1; BRaf1; Serine/Threonine-Protein kinase B-Raf Variant; BRaf-1; Non-Specific Serine/Threonine Protein
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P705737
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: BRaf; V-Raf Murine Sarcoma Viral Oncogene-Like Protein B1; B-Raf Proto-Oncogene, Serine/Threonine kinase; Murine Sarcoma Viral (V-Raf) Oncogene Homolog B1; BRaf1; Serine/Threonine-Protein kinase B-Raf Variant; BRaf-1; Non-Specific Serine/Threonine Protein
Species:
Human
Source:
sf9 insect cells
Cat. No.: HY-P705738
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: BRaf; V-Raf Murine Sarcoma Viral Oncogene-Like Protein B1; B-Raf Proto-Oncogene, Serine/Threonine kinase; Murine Sarcoma Viral (V-Raf) Oncogene Homolog B1; BRaf1; Serine/Threonine-Protein kinase B-Raf Variant; BRaf-1; Non-Specific Serine/Threonine Protein
Species:
Human
Source:
sf9 insect cells
Cat. No.: HY-P705739
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: BRaf; V-Raf Murine Sarcoma Viral Oncogene-Like Protein B1; B-Raf Proto-Oncogene, Serine/Threonine kinase; Murine Sarcoma Viral (V-Raf) Oncogene Homolog B1; BRaf1; Serine/Threonine-Protein kinase B-Raf Variant; BRaf-1; Non-Specific Serine/Threonine Protein
Species:
Human
Source:
sf9 insect cells
Cat. No.: HY-P705740
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: BRaf; V-Raf Murine Sarcoma Viral Oncogene-Like Protein B1; B-Raf Proto-Oncogene, Serine/Threonine kinase; Murine Sarcoma Viral (V-Raf) Oncogene Homolog B1; BRaf1; Serine/Threonine-Protein kinase B-Raf Variant; BRaf-1; Non-Specific Serine/Threonine Protein
Species:
Human
Source:
sf9 insect cells
Cat. No.: HY-P85529
Synonyms: FLJ95109; 94 kDa B Raf protein; B Raf 1; B Raf proto oncogene serine threonine protein kinase; B-Raf proto-oncogene serine/threonine-protein kinase; p94; BRaf 1; BRaf; BRaf_HUMAN; BRaf1; cRmil; MGC126806; MGC138284; Murine sarcoma viral; v-Raf; oncogene homolog B1; Murine sarcoma viral v Raf oncogene homolog B1; NS7; oncogene BRaf1; p94; Proto-oncogene B-Raf; Proto-oncogene c-Rmil; RafB 1; RafB1; RMIL; Serine/threonine-protein kinase B-Raf; v Raf murine sarcoma viral oncogene homolog B; v Raf murine sarcoma viral oncogene homolog B1; v-Raf murine sarcoma viral oncogene homolog B1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
