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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
45 Results for "
RTK
" in MedChemExpress (MCE) Product Catalog:
Products (45)
45 Results for "RTK" in MCE Product Catalog:
Cat. No.: HY-189075
CAS No.: 2843690-50-4
I-0436650 is an orally active SHP2 inhibitor with an IC50 of 4 nM and a Kd value of 0.3 nM. I-0436650 binds allosterically to the channel between the C-SH2, N-SH2 and PTP catalytic domains, locking the protein in an inactive closed conformation. I-0436650 potently inhibits ERK phosphorylation and suppresses MAPK pathway activity. I-0436650 exhibits antiproliferative activity in EGFR- and RAS-dependent cells. I-0436650 can be used in the research of RAS-driven cancers, EGFR-mutated cancers and RTK-driven cancers .
Cat. No.: HY-P85119
Synonyms: DDR1; CAK; EDDR1; NEP; NTRK4; PTK3A; RTK6; TRKE; Epithelial discoidin domain-containing receptor 1; Epithelial discoidin domain receptor 1; CD167 antigen-like family member A; Cell adhesion kinase; Discoidin receptor tyrosine kinase; HGK2;
Cat. No.: HY-P705128
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: DDR1; HGK2; Prev. EDDR1; Neurotrophic Tyrosine Kinase, Receptor, Type 4; Prev. NTRK4; Discoidin Domain Receptor Family, Member 1; Prev. PTK3A; Epithelial Discoidin Domain Receptor 1; Prev. CAK; PTK3A Protein Tyrosine Kinase 3A; Prev. NEP; Receptor Protein-Tyrosine Kinase; RTK6; Neuroepithelial Tyrosine Kinase; Epithelial Discoidin Domain-Containing Receptor 1; Discoidin Domain Receptor DDR1e; CD167 Antigen-Like Family Member A; Discoidin Domain Receptor DDR1d; Tyrosine Kinase DDR; Protein-Tyrosine Kinase 3A; CD167; CD167a Antigen; Discoidin Receptor Tyrosine Kinase; MCK-10; Protein-Tyrosine Kinase RTK-6; MCK10; Mammary Carcinoma Kinase 10; TRK E; Tyrosine-Protein Kinase CAK; PTK3; Cell Adhesion Kinase; DDR; Discoidin Domain Receptor Tyrosine Kinase 1; TRKE
Species:
Human
Source:
HEK293
Cat. No.: HY-P706032
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: DDR1; HGK2; Prev. EDDR1; Neurotrophic Tyrosine Kinase, Receptor, Type 4; Prev. NTRK4; Discoidin Domain Receptor Family, Member 1; Prev. PTK3A; Epithelial Discoidin Domain Receptor 1; Prev. CAK; PTK3A Protein Tyrosine Kinase 3A; Prev. NEP; Receptor Protein-Tyrosine Kinase; RTK6; Neuroepithelial Tyrosine Kinase; Epithelial Discoidin Domain-Containing Receptor 1; Discoidin Domain Receptor DDR1e; CD167 Antigen-Like Family Member A; Discoidin Domain Receptor DDR1d; Tyrosine Kinase DDR; Protein-Tyrosine Kinase 3A; CD167; CD167a Antigen; Discoidin Receptor Tyrosine Kinase; MCK-10; Protein-Tyrosine Kinase RTK-6; MCK10; Mammary Carcinoma Kinase 10; TRK E; Tyrosine-Protein Kinase CAK; PTK3; Cell Adhesion Kinase; DDR; Discoidin Domain Receptor Tyrosine Kinase 1; TRKE
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-L015
1,149 compounds
The PI3K/Akt/mTOR pathway controls many cellular processes that are important for the formation and progression of cancer, including apoptosis, transcription, translation, metabolism, angiogenesis, and cell cycle progression. Every major node of this signaling network is activated in a wide range of human tumors. Mechanisms for the pathway activation include activation of receptor tyrosine kinases (RTKs) upstream of PI3K, mutation or amplification of PIK3CA encoding p110α catalytic subunit of PI3K, mutation or loss of PTEN tumor suppressor gene, and mutation or amplification of Akt1. Once the pathway is activated, signaling through Akt can stimulate a series of substrates including mTOR which is involved in protein synthesis. Thus, inhibition of this pathway is an attractive concept for cancer prevention and/or therapy. Currently some mTOR inhibitors are approved for several indications, and there are several novel PI3K/Akt/mTOR inhibitors in clinical trials.
MCE owns a unique collection of 1,149 compounds that can be used for PI3K/Akt/mTOR pathway research. PI3K/Akt/mTOR Compound Library also acts as a useful tool for anti-cancer drug discovery.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
