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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
47 Results for "
VIM
" in MedChemExpress (MCE) Product Catalog:
Products (47)
47 Results for "VIM" in MCE Product Catalog:
Cat. No.: HY-189006
CAS No.: 3066273-36-4
Target:
Research Areas:
MBL-IN-7 is a potent metallo-β-lactamase (MBLs) inhibitor. The IC50 values of MBL-IN-7 against NDM-1, IMP-1, VIM-1, VIM-2, and L1 are 11 nM, 69 nM, 29 nM, 12 nM, and 85 μM, respectively. MBL-IN-7 is an antibiotic adjuvant. MBL-IN-7 competitively inhibits enzyme activity primarily by coordinating with zinc ions in the active site of MBLs and forming hydrogen bonds and π interactions, thereby protecting carbapenem antibiotics from hydrolysis. MBL-IN-7 is applicable to research related to carbapenem-resistant Gram-negative bacterial infections .
Cat. No.: HY-109124AR
CAS No.: 2244235-49-0
Synonyms: VNRX-5133 hydrochloride (Standard)
Research Areas:
Taniborbactam hydrochloride (Standard) is the analytical standard of Taniborbactam (hydrochloride) (HY-109124A). This product is intended for research and analytical applications. Taniborbactam hydrochloride (VNRX-5133 hydrochloride) is a reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor with IC50s of 8-530 nM. Taniborbactam hydrochloride has IC50s of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2. Taniborbactam hydrochloride is against Gram-negative bacteria .
Cat. No.: HY-182058
Target:
Research Areas:
ATM potentiators-1 is a quercetin derivative that synergistically enhances the antibacterial activity of Aztreonam (ATM, HY-B0129) against metallo-β-lactamase-producing Pseudomonas aeruginosa. ATM potentiators-1 inhibits NDM-1, OXA-10, VIM-2, KPC-2, and OXA-48, suppressing the efflux pump activity of Pseudomonas aeruginosa. When used in combination with CCCP (HY-100941), it exhibits a synergistic inhibitory effect. ATM potentiators-1 is applicable to research related to Pseudomonas aeruginosa infections .
Cat. No.: HY-189634
Target:
Research Areas:
Fmoc-FFC is a competitive MBL (NDM-1, VIM-2, and IMP-1) inhibitor with Ki values of 2.3, 6.0, and 7.1 μM, respectively. Fmoc-FFC alone has no antibacterial activity, but acts synergistically with Meropenem (HY-13678) to restore antibacterial activity against MBL/NDM-1-producing E. coli. Fmoc-FFC supports cell-cell adhesion and can serve as a scaffold for cell culture growth. Fmoc-FFC can be used in research on systemic infections caused by NDM-1-producing E. coli .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
