MBL-IN-7
MBL-IN-7 is a potent metallo-β-lactamase (MBLs) inhibitor. The IC50 values of MBL-IN-7 against NDM-1, IMP-1, VIM-1, VIM-2, and L1 are 11 nM, 69 nM, 29 nM, 12 nM, and 85 μM, respectively. MBL-IN-7 is an antibiotic adjuvant. MBL-IN-7 competitively inhibits enzyme activity primarily by coordinating with zinc ions in the active site of MBLs and forming hydrogen bonds and π interactions, thereby protecting carbapenem antibiotics from hydrolysis. MBL-IN-7 is applicable to research related to carbapenem-resistant Gram-negative bacterial infections.
For research use only. We do not sell to patients.
- CAS No.: 3066273-36-4
- Formula: C19H14ClNO4
- Molecular Weight:355.77
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
NDM-1 11 nM (IC50) |
IMP-1 69 nM (IC50) |
VIM-1 29 nM (IC50) |
VIM-2 12 nM (IC50) |
L1 85 μM (IC50) |
In Vitro
MBL-IN-7 (compound 74) (up to 128 μg/mL) synergizes with Imipenem (HY-B1369A) and Meropenem (HY-13678) to restore their antibacterial activity in NDM-1-producing E. coli BAA-2471, K. pneumoniae BAA-2473, and A. baumannii BAA-3302[1].
The combination of MBL-IN-7 and Imipenem induces bacterial cell membrane rupture and cellular deformation in K. pneumoniae ATCC BAA-2473[1].
MBL-IN-7 potently inhibits the activity of purified NDM-1, IMP-1, VIM-1, VIM-2, and L1 metallo-β-lactamases, with IC50 values of 11 nM, 69 nM, 29 nM, 12 nM, and 85 μM, respectively[1].
MBL-IN-7 interacts with amino acid side chains and zinc ions in the active sites of the purified metallo-β-lactamase proteins NDM-1, IMP-1, and VIM-1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Parmacokinetics
| Species | Dose | Route | T1/2 | CLplasma | C0 | AUC0-last | AUC0-inf | MRT | Vss |
|---|---|---|---|---|---|---|---|---|---|
| Mice[1] | 5.0 mg/kg | i.v. | 4.11 h | 3.63 mL/min/kg | 24356.00 ng/mL | 19596.71 ng·h/mL | 19919.53 ng·h/mL | 4.93 h | 1.08 L/kg |
Chemical Information
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CAS No. 3066273-36-4
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Molecular Weight 355.77
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Formula C19H14ClNO4
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SMILES
O=C(O)C(N1)=C(C2=C(OC)C=CC(Cl)=C2)C3=C1C4=C(OC3)C=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MBL-IN-7 Related Classifications
HY-189006 Related Classifications
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