Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
50 Results for "
cell encapsulation
" in MedChemExpress (MCE) Product Catalog:
Products (50)
50 Results for "cell encapsulation" in MCE Product Catalog:
Cat. No.: HY-W1052178D
Synonyms: Folate-PEG1000-Cholesterol
Cat. No.: HY-W1052178E
Synonyms: Folate-PEG400-Cholesterol
Cat. No.: HY-W1052178H
Synonyms: Folate-PEG600-Cholesterol
Cat. No.: HY-188101
CD19 CAR mRNA (Human)-LNP is a lipid nanoparticle (LNP) encapsulating CD19 CAR mRNA (Human). CD19 CAR mRNA (Human) can express a CAR protein targeting human CD19. CD19 CAR mRNA can trigger transient CAR expression, allowing T cells to be targeted without permanent genetic modification. CD19 CAR mRNA can be used in cancer research such as lymphoma and leukemia.
Cat. No.: HY-188102
mCherry mRNA (N1-Me-Pseudo UTP)-LNP is a lipid nanoparticle (LNP) encapsulating mCherry mRNA (N1-Me-Pseudo UTP). mCherry mRNA (N1-Me-Pseudo UTP) is a reporter mRNA encoding a red fluorescent protein, suitable for gene expression, cell viability, in vivo imaging, and other detection methods. mCherry is a red fluorescent protein derived from mushroom coral and is widely used in biotechnology as a red fluorescent dye tracer.
Cat. No.: HY-185760
F-L319 is an ionizable lipid and spleen-targeting mRNA delivery vector. F-L319 can be formulated into lipid nanoparticles (LNPs) to drive spleen-restricted reporter protein expression in mice. F-L319 modulates mRNA encapsulation efficiency, cellular uptake efficiency, and delivery efficiency, with effects varying depending on the composition of LNP formulations. When prepared as pure LNPs, F-L319 shows poor mRNA delivery efficiency in cells; in contrast, hybrid LNPs containing F-L319 and L319 significantly enhance mRNA delivery efficiency in cells .
Cat. No.: HY-181967
Target:
Research Areas:
PROTAC PARP1 degrader-5 is a PARP1 PROTAC degrader with a DC50 of 0.12 μM. PROTAC PARP1 degrader-5 hijacks the ubiquitin-proteasome system via catalytic ternary complex formation to drive sustained PARP1 degradation. PROTAC PARP1 degrader-5 induces DNA damage, drives marginal cytosolic double-stranded DNA accumulation in tumor cells, and up-regulates PD-L1 surface expression in tumor cells. PROTAC PARP1 degrader-5 shows tumor growth inhibition activity in murine melanoma models when encapsulated in lipid nanoparticles. PROTAC PARP1 degrader-5 can be used for the research of cancer, such as melanoma .
Cat. No.: HY-184639
Carboxylated magnetic microspheres (low nonspecificity) are functionalized nano- or micron-sized magnetic particles with abundant carboxyl functional groups on their surface. Special chemical treatments reduce the likelihood of nonspecific adsorption. This 1μm carboxylated magnetic microsphere features a core-shell structure: a PS core, an outer layer of iron oxide (Fe3O4), and an outermost encapsulation layer. The carboxyl groups are obtained through polymer modification. Exhibiting low nonspecific adsorption, these microspheres can covalently couple with bioligands such as peptides, proteins, antibodies, and oligonucleotides using specific chemical reagents (e.g., EDC), making them particularly suitable for cell sorting, affinity chromatography, and immunoassay.
Cat. No.: HY-L180
655 compounds
Mitochondrial autophagy refers to the selective encapsulation and degradation of damaged mitochondria by cells through the autophagy mechanism, thereby maintaining mitochondrial and cellular homeostasis. The concept of mitochondrial autophagy has received extensive attention since it was proposed. Current studies have shown that the mechanisms of mitochondrial autophagy can generally be divided into two categories: Ubiquitin-dependent pathways and Ub-independent pathways. In addition, mitochondrial autophagy is a research hotspot related to the pathogenesis of neurodegenerative diseases, cardiovascular diseases, cancer, metabolic diseases and other clinical diseases. Therefore, high-throughput screening based on mitochondrial autophagy can effectively screen out compounds that are closely related to the occurrence of diseases and analyze their mechanisms.
MCE can provide a library of 655 mitophagy compounds, which can be used for drug development and mechanism research in cancer, immunity, infection and other hot research fields.
Cat. No.: HY-L214
227 compounds
Liposomes are spherical or multilayered spherical vesicles formed by the self-assembly of diacyl chain phospholipids (lipid bilayers) in aqueous solutions, which can be made from natural or synthetic phospholipids and exhibit good biocompatibility and low toxicity. They can serve as delivery carriers for various bioactive substances (such as drugs, proteins, nucleic acids, etc.) and are widely used in biomedical and chemical research. The main advantages of liposomes include 1) Protective effect: Their bilayer structure can protect encapsulated molecules from enzymatic degradation, oxidation, and other influences, extending stability and activity; 2) Active targeting: Surface modifications enable active targeting, enhancing the concentration of drugs or molecules in specific tissues or cells; 3) Customizability: The composition and structure of liposomes can be adjusted according to needs, such as altering phospholipid types or adding targeting ligands. These properties make liposomes highly valuable in developing novel drug delivery systems, serving as nucleic acid carriers for gene transfection, studying cellular uptake mechanisms and drug release kinetics, as well as developing functional food additives to improve the bioavailability of nutritional components.
MCE contains 227 liposome compounds, which is a good tool for drug delivery-related studies.
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
