Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
926 Results for "
dysfunction
" in MedChemExpress (MCE) Product Catalog:
Products (926)
926 Results for "dysfunction" in MCE Product Catalog:
7
7 Cited Publications
Synonyms: Nω-Hydroxy-nor-L-arginine dihydrochloride
Research Areas:
Cardiovascular Disease Infection Metabolic Disease Inflammation/Immunology Cancer
nor-NOHA dihydrochloride is a selective and reversible Arginase inhibitor. nor-NOHA dihydrochloride induces Apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA dihydrochloride has anti-leukemic activity. nor-NOHA dihydrochloride improves liver ischemia-reperfusion injury. nor-NOHA dihydrochloride can used in study of tuberculosis, endothelial dysfunction, immunosuppression and metabolism .
7
Research Areas:
Perhexiline is an orally active CPT1 and CPT2 inhibitor that reduces fatty acid metabolism. Perhexiline induces mitochondrial dysfunction and apoptosis in hepatic cells. Perhexiline can cross the blood brain barrier (BBB) and shows anti-tumor activity. Perhexiline can be used in the research of cancers, and cardiovascular disease like angina .
7
7 Cited Publications
Cat. No.: HY-N0010
CAS No.: 27741-01-1
Category:
other families Iridoids Terpenoids Plants Endogenous metabolite Disease Research Fields Cancer
Target:
7
Category:
Cardiovascular Disease Ophiopogon japonicus (L. f.) Ker-Gawl. Liliaceae Plants Disease Research Fields Steroids
Target:
7
7 Cited Publications
Cat. No.: HY-18734A
CAS No.: 148819-94-7
Target:
Research Areas:
Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Carboxy-PTIO potassium is a potent nitric oxide (NO) scavenger that can make a quick reaction with NO to produce NO2. Carboxy-PTIO potassium can prevent hypotension and endotoxic shock through the direct scavenging action against NO in lipopolysaccharide-stimulated rat model .
7
7
7 Cited Publications
Synonyms: ABBV-CLS-484
Target:
Research Areas:
Osunprotafib (ABBV-CLS-484) is an orally active and selective active site PTPN1 (IC50: 2.5 nM) and PTPN2(IC50: 1.8 nM) inhibitor. Osunprotafib has 6-8-fold weaker activity on PTPN9 and no detectable activity on SHP-1 or SHP-2. Osunprotafib increases the sensitivity of human cancer cell lines to IFNγ. Osunprotafib generates robust anti-tumor immunity by enhancing JAK-STAT signalling and reducing T cell dysfunction .
7
Research Areas:
Cardiovascular Disease Metabolic Disease Endocrinology Cancer
Spironolactone is an aldosterone antagonist that acts on the aldosterone mineralocorticoid receptor (IC50=24 nM) and androgen receptor (IC50=77 nM), promotes podocyte autophagy and regulates pain. Spironolactone improves hypertension-related vascular hypertrophy and remodeling by reducing angiotensin II (Ang II)-induced inflammation, reduces aldosterone-induced vascular and soft tissue calcification through PIT1-dependent signaling, and alleviates vascular dysfunction in type II diabetic mice by reducing oxidative stress and restoring NO/GC signaling; at low concentrations, it and its metabolites can interfere with aldosterone biosynthesis in the adrenal cortex and inhibit voltage-dependent Ca 2+ channels to exert antihypertensive effects .
6
6 Cited Publications
Cat. No.: HY-W094474
CAS No.: 85144-11-2
Synonyms: hydrate/monohydrateortrihydrate
Research Areas:
Lithium chloride hydrate, an orally active mood stabilizer, is a potent virus inhibitor and effective immunomodulatory agent. Lithium chloride hydrate has antidepressant activity by inhibiting GSK3β and promoting neurogenesis. Lithium chloride hydrate alleviates cognition dysfunction and the symptoms of acute mania and depression. Lithium chloride hydrate can also be used for research of virus infection and Alzheimer's disease .
6
6 Cited Publications
Cat. No.: HY-B0442
CAS No.: 224785-90-4
6
6 Cited Publications
Cat. No.: HY-B0442A
CAS No.: 224785-91-5
6
6 Cited Publications
Cat. No.: HY-B0442B
CAS No.: 330808-88-3
6
6 Cited Publications
Target:
Research Areas:
Bisoprolol is a potent, selective and orally active β1-adrenergic receptor blocker with little activity on β2-receptor. Bisoprolol has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research .
6
6 Cited Publications
Cat. No.: HY-B0076
CAS No.: 104344-23-2
Target:
Research Areas:
Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Bisoprolol hemifumarate is a potent, selective and orally active β1-adrenergic receptor blocker with little activity on β2-receptor. Bisoprolol hemifumarate has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research .
6
6 Cited Publications
Cat. No.: HY-17369
CAS No.: 150915-40-5
Synonyms: L700462 hydrochloride monohydrate; MK383 hydrochloride monohydrate
Target:
Research Areas:
Tirofiban (L700462) hydrochloride monohydrate is a selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist that inhibits fibrinogen binding to this receptor and has antithrombotic activity. Tirofiban hydrochloride monohydrate induces proliferation and migration on endothelial cell by inducing production of VEGF. Tirofiban hydrochloride monohydrate can significantly reduces myocardial no-reflow and ischemia-reperfusion injury by alleviating myocardial microvascular structural and endothelial dysfunction in the ischemic area .
6
Target:
Research Areas:
Tirofiban (L700462) is a selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist that inhibits fibrinogen binding to this receptor and has antithrombotic activity. Tirofiban induces proliferation and migration on endothelial cell by inducing production of VEGF. Tirofiban can significantly reduces myocardial no-reflow and ischemia-reperfusion injury by alleviating myocardial microvascular structural and endothelial dysfunction in the ischemic area .
6
6 Cited Publications
Synonyms: p-Tolyl sulfate
Target:
6
Target:
Research Areas:
NNC 55-0396 (NNC 55-0396 dihydrochloride) is a blood-brain-barrier-permeable T-type Ca 2+ channel inhibitor and pan-P450 inhibitor. NNC 55-0396 selectively inhibits T-type Ca 2+ channels, suppresses HIF-1α expression and stability and inhibits Kv currents. NNC 55-0396 reduces brain infarct and attenuates neurological dysfunction. NNC 55-0396 inhibits the activity of multiple P450 enzymes. NNC 55-0396 (free base) can be used for the research of brain injury, hypertension, and glioblastoma .
6
Phenelzine sulfate, an antidepressant agent, is an irreversible and orally active monoamine oxidase (MAO-A and MAO-B) inhibitor. Phenelzine sulfate inhibits GABA transaminase and primary amine oxidase (PrAO), and sequester reactive aldehydes. Phenelzine sulfate also inhibits LSD1 (Ki: 5.6 μM) and suppresses oxidative stress and lipogenesis. Phenelzine sulfate elevates neurotransmitters (serotonin, norepinephrine, dopamine). Phenelzine sulfate is studied in neurological, metabolic and cancer diseases for depression and anxiety disorders, stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, inflammatory pain, obesity and prostate cancer .
5
5 Cited Publications
Cat. No.: HY-118861
CAS No.: 15690-57-0
Synonyms: (E)-Clomiphene; trans-Clomiphene; Enclomifene
Target:
Research Areas:
Enclomiphene ((E)-Clomiphene) is a potent and orally active non-steroidal estrogen receptor antagonist, with antioestrogenic property. Enclomiphene can be used for the research of ovarian dysfunction, testosterone deficiency, male hypogonadism and type 2 diabetes .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
