Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
129 Results for "
pathogenesis
" in MedChemExpress (MCE) Product Catalog:
Products (129)
129 Results for "pathogenesis" in MCE Product Catalog:
Target:
Research Areas:
Secnidazole (Standard) is the analytical standard of Secnidazole. This product is intended for research and analytical applications. Secnidazole (RP-14539) is an orally active azole antibiotic and a imidazole mitigator of Serratia marcescens virulence. Secnidazole, as an analog of acylhomoserine lactones, effectively inhibits QS resulting in the attenuation of Pseudomonas aeruginosa pathogenesis. Secnidazole has antimicrobial activity against many anaerobic Gram-negative and Gram-positive bacterial species in vitro. Secnidazole can be used for the research of various diseases, such as amoebiasis and giardiasis, and bacterial vaginitis .
Cat. No.: HY-157639A
Target:
Research Areas:
18:2 Lyso PA sodium is an unsaturated lysophosphatidic acid (LysoPA), a lipid mediator mainly present in plasma and thought to be involved in the pathogenesis of acute coronary syndrome (ACS). 18:2 Lyso PA sodium significantly correlates with serum autotaxin (ATX) in peripheral arteries .
Cat. No.: HY-W009390S
CAS No.: 108641-82-3
Synonyms: VV116 free base; GS-621763-d1
Cat. No.: HY-121252A
CAS No.: 5707-55-1
Target:
Research Areas:
Dopal (purity>80%) is a metabolite and aldehyde neurotoxin of Dopamine (HY-B0451). Dopal (purity>80%) exhibits cytotoxicity, induces α-synuclein oligomerization and aggregation, and is closely associated with the pathogenesis of Parkinson's disease. Dopal (purity>80%) can be used in research related to Parkinson's disease .
Cat. No.: HY-P1363S
Synonyms: Amyloid β-peptide-15N (1-42) (human) TFA
Target:
Research Areas:
Cat. No.: HY-W095705
CAS No.: 503-66-2
Target:
Research Areas:
3-Hydroxypropionic acid (30% in water) is a metabolite of β-Alanine (HY-N0230) and also a precursor for the synthesis of various chemical products. 3-Hydroxypropionic acid (30% in water) exhibits reduced urinary levels in elderly male patients with nocturia, which correlates with altered β-Alanine metabolic pathogenesis. 3-Hydroxypropionic acid (30% in water) can be used in studies related to nocturia .
Cat. No.: HY-148451
CAS No.: 1402931-75-2
Research Areas:
eIF4A3-IN-17 (compound 61) is a Silvestrol (HY-13251) analogue. eIF4A3-IN-17 interferes the assembling of eIF4F translation complex with EC50s of 0.9, 15 and 1.8 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-17 can be used for the research of human cancer pathogenesis .
Cat. No.: HY-W103964
CAS No.: 300543-56-0
HCV-IN-47 (Compound (R)-1) shows anti-hepatitis C virus (HCV) activity with an EC50 value of 0.032 μM. HCV-IN-47 is promising for research of hepatitis C virus pathogenesis, and host-virus interaction .
Cat. No.: HY-P1362A
Synonyms: Amyloid β Peptide (42-1)(human) TFA
Target:
Research Areas:
Cat. No.: HY-174620
Target:
Research Areas:
Human IL22 mRNA encodes the human interleukin 22 (IL22) protein, a member of the IL10 family of cytokines that mediate cellular inflammatory responses. IL22 functions in antimicrobial defense at mucosal surfaces and in tissue repair. It also has pro-inflammatory properties and plays a role in in the pathogenesis of several intestinal diseases.
Cat. No.: HY-103018A
CAS No.: 2228989-14-6
Synonyms: ASN-002 hydrochloride
Research Areas:
Gusacitinib (ASN-002) hydrochloride is an orally active dual SYK/JAK kinase inhibitor with IC50 values of 5, 46, 4, 11 and 8 nM for SYK, JAK1, JAK2, JAK3 and TYK2, respectively. Gusacitinib hydrochloride rapidly and significantly suppressed key inflammatory pathways implicated in atopic dermatitis pathogenesis. Gusacitinib hydrochloride can be used in the research of chronic hand eczema and cancers such as basal cell carcinoma .
Cat. No.: HY-148445
CAS No.: 1402931-70-7
Research Areas:
eIF4A3-IN-11 (compound 56) is a Silvestrol (HY-13251) analogue. eIF4A3-IN-11 interferes the assembling of eIF4F translation complex with EC50s of 0.2, 4 and 0.3 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-11 can be used for the research of human cancer pathogenesis .
Cat. No.: HY-200854
CAS No.: 2447007-60-3
Synonyms: LNP023 hydrochloride hydrate
Target:
Research Areas:
Iptacopan (LNP023) hydrochloride hydrate is an effective and orally-active highly selective factor B inhibitor with an IC50 value of 10 nM and KD of 7.9 nM. Iptacopan hydrochloride hydrate exerts a proximal effect in the complement cascade reaction, preventing the destruction (hemolysis) of red blood cells in PNH and the damage of renal cells in IgAN and C3G. Iptacopan hydrochloride hydrate can be used for the study of complement-mediated diseases, particularly paroxysmal nocturnal hemoglobinuria (PNH), primary immunoglobulin A nephropathy (IgAN), and complement 3 glomerulopathy (C3G) .
Cat. No.: HY-119210
CAS No.: 364052-84-6
ZINC04177596 is a potent HIV-negative factor (HIV-Nef) protein inhibitor. Nef is an accessory gene product of HIV and has an imperative role in viral replication and AIDS pathogenesis .
Cat. No.: HY-114080B
CAS No.: 3031765-17-7
Synonyms: E-3123 hydrochloride
Target:
Research Areas:
Patamostat hydrochloride is a potent protease inhibitor. Patamostat hydrochloride potently inhibits trypsin, plasmin and thrombin with IC50s of 39 nM, 950 nM and 1.9 μM, respectively. Patamostat hydrochloride may possess suppressing effects on pathogenesis and development of acute pancreatitis .
Cat. No.: HY-114080A
CAS No.: 114568-32-0
Synonyms: E-3123 mesylate
Target:
Research Areas:
Patamostat (E-3123) mesylate is a potent protease inhibitor. Patamostat mesylate potently inhibits trypsin, plasmin and thrombin with IC50s of 39 nM, 950 nM and 1.9 μM, respectively. Patamostat mesylate may possess suppressing effects on pathogenesis and development of acute pancreatitis .
Cat. No.: HY-114080R
CAS No.: 114568-26-2
Synonyms: E-3123 (Standard)
Target:
Research Areas:
Patamostat (Standard) is the analytical standard of Patamostat. This product is intended for research and analytical applications. Patamostat (E-3123) is a potent protease inhibitor. Patamostat potently inhibits trypsin, plasmin and thrombin with IC50s of 39 nM, 950 nM and 1.9 μM, respectively. Patamostat may possess suppressing effects on pathogenesis and development of acute pancreatitis .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
