2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC Sirtuin
  4. Mz325

Mz325 is a dual inhibitor of HDAC and Sirt2, with the IC50 of 9.7 μM to Sirt2, that play an important role in pathogenesis of cancer and neurodegeneration.

For research use only. We do not sell to patients.

Mz325

Mz325 Chemical Structure

CAS No. : 3032670-12-2

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Based on 1 publication(s) in Google Scholar

Mz325 Related Antibodies

Top Publications Citing Use of Products

View All HDAC Isoform Specific Products:

View All Isoforms
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

View All Sirtuin Isoform Specific Products:

View All Isoforms
Sirtuin SIRT1 SIRT2 SIRT3 SIRT6 SIRT5 SIRT7 SIRT4

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Description

Mz325 is a dual inhibitor of HDAC and Sirt2, with the IC50 of 9.7 μM to Sirt2, that play an important role in pathogenesis of cancer and neurodegeneration[1].

Molecular Weight

771.95

Formula

C38H45N9O5S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=NC=C(S1)CC2=CC=CC(OCC3=CN(N=N3)CCCCC(N(CC4=CC=C(C=C4)C(NO)=O)CCCC)=O)=C2)CSC5=NC(C)=CC(C)=N5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (129.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2954 mL 6.4771 mL 12.9542 mL
5 mM 0.2591 mL 1.2954 mL 2.5908 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2954 mL 6.4771 mL 12.9542 mL 32.3855 mL
5 mM 0.2591 mL 1.2954 mL 2.5908 mL 6.4771 mL
10 mM 0.1295 mL 0.6477 mL 1.2954 mL 3.2386 mL
15 mM 0.0864 mL 0.4318 mL 0.8636 mL 2.1590 mL
20 mM 0.0648 mL 0.3239 mL 0.6477 mL 1.6193 mL
25 mM 0.0518 mL 0.2591 mL 0.5182 mL 1.2954 mL
30 mM 0.0432 mL 0.2159 mL 0.4318 mL 1.0795 mL
40 mM 0.0324 mL 0.1619 mL 0.3239 mL 0.8096 mL
50 mM 0.0259 mL 0.1295 mL 0.2591 mL 0.6477 mL
60 mM 0.0216 mL 0.1080 mL 0.2159 mL 0.5398 mL
80 mM 0.0162 mL 0.0810 mL 0.1619 mL 0.4048 mL
100 mM 0.0130 mL 0.0648 mL 0.1295 mL 0.3239 mL
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Mz325 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mz3253032670-12-2Mz 325Mz-325HDACSirtuinHistone deacetylasesHDAC/Sirt2 inhibitorcancerneurodegenerationInhibitorinhibitorinhibit

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