114568-26-2
114568-26-2
Chemical Structure
Patamostat
Synonym(s): E-3123
- CAS No.: 114568-26-2
- Formula:C20H20N4O4S
- Molecular Weight:412.46
IUPAC Name: 4-((2-(2,5-dioxopyrrolidin-1-yl)ethyl)thio)phenyl 4-guanidinobenzoate
InChIKey: ILRQPCQIFIURTG-UHFFFAOYSA-N
SMILES: O=C(OC1=CC=C(SCCN2C(CCC2=O)=O)C=C1)C3=CC=C(NC(N)=N)C=C3
Biological Activity: Patamostat (E-3123) is a potent protease inhibitor. Patamostat potently inhibits trypsin, plasmin and thrombin with IC50s of 39 nM, 950 nM and 1.9 μM, respectively. Patamostat may possess suppressing effects on pathogenesis and development of acute pancreatitis[1][2].
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Patamostat | 98.13% | Patamostat (E-3123) is a potent protease inhibitor. Patamostat potently inhibits trypsin, plasmin and thrombin with IC50s of 39 nM, 950 nM and 1.9 μM, respectively. Patamostat may possess suppressing effects on pathogenesis and development of acute pancreatitis. | ||||||||||||||||||||
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Patamostat (Standard) | ≥98% | Patamostat (Standard) is the analytical standard of Patamostat. This product is intended for research and analytical applications. Patamostat (E-3123) is a potent protease inhibitor. Patamostat potently inhibits trypsin, plasmin and thrombin with IC50s of 39 nM, 950 nM and 1.9 μM, respectively. Patamostat may possess suppressing effects on pathogenesis and development of acute pancreatitis. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.99
HY-114080BPatamostat hydrochloride -
Similarity Score 0.92
HY-114080APatamostat mesylate -
Similarity Score 0.66
HY-167924Ono 3307 free base -
Similarity Score 0.64
HY-1378144-Nitrophenyl 4-guanidinobenzoate hydrochloride -
Similarity Score 0.64
HY-19727FOY 251 free base -
Similarity Score 0.63
HY-19101ONO-3307 -
Similarity Score 0.62
HY-19727ARFOY 251 (Standard) -
Similarity Score 0.62
HY-165529Camostat -
Similarity Score 0.60
HY-B0190BNafamostat hydrochloride -
Explore the MedChemAI to find more analogs
References
- [1]. K Miyamoto, et al. [Effects of E-3123, a New Protease Inhibitor, on Several Protease Activities and on Experimental Acute Pancreatitis]. Nihon Yakurigaku Zasshi. 1988 May;91(5):285-93. [Content Brief]
- [2]. T Hirano, et al. Protective Effect of a Cephalosporin, Shiomarin, Plus a New Potent Protease Inhibitor, E3123, on Rat Taurocholate-Induced Pancreatitis. J Gastroenterol Hepatol. Jan-Feb 1993;8(1):52-9. [Content Brief]
