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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
641 Results for "
ADP HPD
" in MedChemExpress (MCE) Product Catalog:
Products (641)
641 Results for "ADP HPD" in MCE Product Catalog:
Cat. No.: HY-P703626
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: SIRT6; HSIRT6; Sirtuin 6; SIR2L6; Protein Mono-ADP-Ribosyltransferase Sirtuin-6; Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 6 (S. Cerevisiae); NAD-Dependent Protein Deacetylase Sirtuin-6; Sirtuin (Silent Mating Type Information Regulati
Species:
Human
Source:
E. coli
Cat. No.: HY-W004643
CAS No.: 13114-72-2
Synonyms: AK-II
Research Areas:
Akardite II (AK-II) is a stabilizer for nitrocellulose (NC) propellants that scavenges NOx. Akardite II is used in research related to the identification of organic compounds in gunpowder .
Cat. No.: HY-P76525
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: NUDT5; Nucleoside Diphosphate-Linked Moiety X Motif 5; Nudix Hydrolase 5; HYSAH1; YSA1H; HNUDT5; Nuclear ATP-Synthesis Protein NUDIX5; Nudix Motif 5; ADP-Sugar Pyrophosphatase; NUDIX5; 8-Oxo-DGDP Phosphatase; YSAH1; Nudix (Nucleoside Diphosphate Linked Mo
Species:
Human
Source:
E. coli
Cat. No.: HY-137325A
CAS No.: 301334-89-4
Target:
Research Areas:
2-Chloro-ATP sodium (2-Chloro ATP) is an adenine nucleotide and an analog of ATP. It is an antagonist of the purinergic P2Y1 receptor and inhibits intracellular calcium mobilization induced by ADP (HY-W010918) in Jurkat cells expressing the human receptor (Ki=2.3 μM). 2-Chloro-ATP sodium is an agonist of the purinergic P2X receptor and induces inward currents in HEK293 cells expressing human bladder smooth muscle or rat PC12 forms of the receptor (EC50=0.5 and 2.5 μM). 2-Chloro-ATP sodium induces relaxation of precontracted guinea pig cecal strips in a concentration-dependent manner. 2-Chloro-ATP sodium has been used to study the substrate specificity of cyclic nucleotide-dependent protein kinases such as protein kinase A (PKA) and PKG.
Cat. No.: HY-175675
CAS No.: 3104888-50-5
Target:
Research Areas:
P2Y1 antagonist 4 is a selective P2Y1 receptor antagonist with excellent blood-brain barrier (BBB) penetration.
P2Y1 antagonist 4 inhibits P2Y1 receptor-mediated cytosolic Ca 2+ increase (IC50 = 1.95 μM) and platelet aggregation (IC50 = 3.24 μM) induced by ADP in rabbit washed platelets. P2Y1 antagonist 4 significantly upregulates the level of nuclear Nrf2 protein in H2O2-treated HT22 cells. P2Y1 antagonist 4 reduces myocardial infarct size in a mouse acute myocardial infarction (MI) model. P2Y1 antagonist 4 can be used for the study of ischemic stroke and myocardial infarction .
Cat. No.: HY-P76525Y
Purity: ≥ 90%, as determined by Bis-Tris PAGE.
Synonyms: NUDT5; Nucleoside Diphosphate-Linked Moiety X Motif 5; Nudix Hydrolase 5; HYSAH1; YSA1H; HNUDT5; Nuclear ATP-Synthesis Protein NUDIX5; Nudix Motif 5; ADP-Sugar Pyrophosphatase; NUDIX5; 8-Oxo-DGDP Phosphatase; YSAH1; Nudix (Nucleoside Diphosphate Linked Mo
Species:
Human
Source:
E. coli
Cat. No.: HY-125209A
CAS No.: 2253744-57-7
Target:
Research Areas:
TH5427 hydrochloride is a NUDT5 inhibitor with a human target IC50 of 29 nM, ~690-fold selectivity over MTH1 in vitro, and selective functional inhibition over other NUDIX hydrolases including NUDT9 .TH5427 hydrochloride binds to the active site of NUDT5, blocking enzymatic activity related to ADP-ribose metabolism and PAR-derived ATP synthesis .TH5427 hydrochloride blocks progestin-dependent nuclear ATP synthesis, impairs progestin-induced chromatin remodeling, inhibits histone H1 displacement, disrupts progestin-dependent gene regulation, and abrogates progestin-dependent proliferation in breast cancer cells .TH5427 hydrochloride functions as a versatile probe to study nuclear ATP dynamics and ADP-ribose-related metabolism in cells .TH5427 hydrochloride engages NUDT5 at physiological temperatures, as demonstrated by Drug Affinity Responsive Target Stability (DARTS) assay .TH5427 hydrochloride stabilizes NUDT5 against thermal denaturation in cell lysates and intact cells, as shown by cellular thermal shift assay (CETSA) .TH5427 hydrochloride functionally inhibits NUDT5 activity, leading to downstream effects on oxidative DNA damage and DNA replication in triple-negative breast cancer (TNBC) cells .TH5427 hydrochloride suppresses proliferation of TNBC cells without inducing cell death or apoptosis, slows DNA replication in TNBC cells, promotes accumulation of oxidative DNA lesions, and triggers DNA damage response in TNBC cells .TH5427 hydrochloride suppresses growth of TNBC cells in vitro, inhibits growth of TNBC xenograft tumors in nude mice in vivo, and shows greater potency against TNBC cell lines compared to ER-positive and normal-like breast cell lines .TH5427 hydrochloride can be used for the research of breast cancer and triple-negative breast cancer .
Cat. No.: HY-N20707
CAS No.: 24312-00-3
Category:
Cat. No.: HY-P87125
Synonyms: ECGF 1 antibody; ECGF antibody; ECGF1 antibody; Endothelial cell growth factor 1 antibody; Endothelial cell growth factor 1 platelet derived antibody; Endothelial cell growth factor, platelet-derived antibody; Gliostatin antibody; HPD ECGF antibody; MEDPS1 antibody; MNGIE antibody; ECGF 1 antibody; ECGF antibody; ECGF1 antibody; Endothelial cell growth factor 1 antibody; Endothelial cell growth factor 1 platelet derived antibody; Endothelial cell growth factor, platelet-derived antibody; Gliostatin antibody; HPD ECGF antibody; MEDPS1 antibody; MNGIE antibody; MTDPS1 antibody; PD ECGF antibody; PD-ECGF antibody; PDECGF antibody; PDEGF antibody; Platelet derived endothelial cell growth factor antibody; Platelet derived endothelial growth factor antibody; Platelet-derived endothelial cell growth factor antibody; TdRPase antibody; Thymidine phosphorylase antibody; TP antibody; Tymp antibody; TYPH_HUMAN antibody;
Cat. No.: HY-123669
CAS No.: 204204-73-9
Target:
Research Areas:
R-138727, the major active metabolite of Prasugrel (HY-15284), is a highly potent and selective irreversible antagonist of the P2Y12 receptor, with an IC50 of 2.5 μM. R-138727 covalently binds to the P2Y12 receptor on the platelet surface, blocking adenosine diphosphate-mediated platelet activation and aggregation. R-138727 can be used to study stroke, cerebral infarction and neurological deficits.
Cat. No.: HY-188120
Research Areas:
AZD5335 is an ADC targeting FRα, with an IC50 of 10.6 nM against human FRα. AZD5335 specifically binds to FRα, mediates internalization and trafficking to lysosomal compartments, while delivering a topoisomerase I inhibitor payload that traps TOP1-DNA cleavage complexes. AZD5335 induces DNA damage response via the ATR, ATM, Chk1 and Chk2 signaling pathways, and increases the levels of phosphorylated KAP1, phosphorylated RPA, phosphorylated γH2AX, as well as PARP cleavage. AZD5335 exhibits bystander cytotoxicity against FRα-negative cells co-cultured with FRα-expressing cells. AZD5335 induces potent and durable responses and complete regression in ovarian cancer models, including models with low FRα expression and models resistant to Elahere, with enhanced efficacy when combined with Carboplatin, Bevacizumab or poly (ADP-ribose) polymerase inhibitors. AZD5335 can be used for ovarian cancer research .
Cat. No.: HY-P85522
Synonyms: 2810449N18Rik; AI043036; Mono ADP ribosyltransferase sirtuin 6; NAD-dependent protein deacetylase sirtuin-6; Regulatory protein SIR2 homolog 6; Regulatory protein SIR2 homolog; SIR2 like 6; SIR2 like protein 6; Sir2 related protein type 6; SIR2-like protein 6; SIR2
Cat. No.: HY-P7398
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD274; B7 Homolog 1; Prev. PDCD1LG1; B7-H; PD-L1; PDCD1 Ligand 1; B7H1; PDCD1L1; PDL1; HPD-L1; Programmed Cell Death 1 Ligand 1; Programmed Death Ligand 1; CD274 Antigen; ADMIO5; CD274 Molecule; B7-H1
Species:
Human
Source:
HEK293
Cat. No.: HY-P70564
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD274; B7 Homolog 1; Prev. PDCD1LG1; B7-H; PD-L1; PDCD1 Ligand 1; B7H1; PDCD1L1; PDL1; HPD-L1; Programmed Cell Death 1 Ligand 1; Programmed Death Ligand 1; CD274 Antigen; ADMIO5; CD274 Molecule; B7-H1
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-P70633
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD274; B7 Homolog 1; Prev. PDCD1LG1; B7-H; PD-L1; PDCD1 Ligand 1; B7H1; PDCD1L1; PDL1; HPD-L1; Programmed Cell Death 1 Ligand 1; Programmed Death Ligand 1; CD274 Antigen; ADMIO5; CD274 Molecule; B7-H1
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P70657
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD274; B7 Homolog 1; Prev. PDCD1LG1; B7-H; PD-L1; PDCD1 Ligand 1; B7H1; PDCD1L1; PDL1; HPD-L1; Programmed Cell Death 1 Ligand 1; Programmed Death Ligand 1; CD274 Antigen; ADMIO5; CD274 Molecule; B7-H1
Species:
Human
Source:
HEK293
Cat. No.: HY-P70663
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD274; B7 Homolog 1; Prev. PDCD1LG1; B7-H; PD-L1; PDCD1 Ligand 1; B7H1; PDCD1L1; PDL1; HPD-L1; Programmed Cell Death 1 Ligand 1; Programmed Death Ligand 1; CD274 Antigen; ADMIO5; CD274 Molecule; B7-H1
Species:
Human
Source:
HEK293
Cat. No.: HY-P71008
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CD274; B7 Homolog 1; Prev. PDCD1LG1; B7-H; PD-L1; PDCD1 Ligand 1; B7H1; PDCD1L1; PDL1; HPD-L1; Programmed Cell Death 1 Ligand 1; Programmed Death Ligand 1; CD274 Antigen; ADMIO5; CD274 Molecule; B7-H1
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-P73364
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD274; B7 Homolog 1; Prev. PDCD1LG1; B7-H; PD-L1; PDCD1 Ligand 1; B7H1; PDCD1L1; PDL1; HPD-L1; Programmed Cell Death 1 Ligand 1; Programmed Death Ligand 1; CD274 Antigen; ADMIO5; CD274 Molecule; B7-H1
Species:
Rat
Source:
HEK293
Cat. No.: HY-P73365
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD274; B7 Homolog 1; Prev. PDCD1LG1; B7-H; PD-L1; PDCD1 Ligand 1; B7H1; PDCD1L1; PDL1; HPD-L1; Programmed Cell Death 1 Ligand 1; Programmed Death Ligand 1; CD274 Antigen; ADMIO5; CD274 Molecule; B7-H1
Species:
Rat
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
