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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
102 Results for "
Affinity probe
" in MedChemExpress (MCE) Product Catalog:
Products (102)
102 Results for "Affinity probe" in MCE Product Catalog:
Cat. No.: HY-101181
CAS No.: 1374107-46-6
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THK-5105, an arylquinoline derivative, displays high binding affinity to tau fibrils. THK-5105 has high binding affinity to tau protein aggregates and tau-rich Alzheimer disease (AD) brain homogenates. 18F-THK-5105 has the potential to act as a tau imaging PET probe .
Cat. No.: HY-111188
CAS No.: 89687-06-9
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A55453 is a prazosin analogue and a potent α1-adrenergic antagonist. 125I-A55453 is a high-affinity alpha 1-adrenergic receptor probe .
Cat. No.: HY-116222
CAS No.: 115103-48-5
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A 53693 is a rigid catecholamine with selective adrenergic agonist activity. A 53693 has affinity for certain rat alpha-2 receptor subtypes. A 53693 shows high selectivity for alpha-2 receptors and, in contrast, has low affinity for alpha-1 receptors. A 53693 is used as a probe in biological studies to explore the molecular interactions of alpha agonist compounds .
Cat. No.: HY-155772
CAS No.: 2941609-83-0
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LUF7690 (Compound 9) is a clickable and covalent affinity-based probe (AfBP) that targets the human A3AR (hA3AR). LUF7690 can be used in the detection and characterization of the hA3AR in different types of granulocytes, among other cell types .
Cat. No.: HY-160063
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SW1 aptamer sodium is a high-affinity DNA aptamer (Kd: 123.62 nM) that targets liver cancer SMMC-7721 cells and targets intracellular components within the nucleus. SW1 aptamer sodium can also identify various other types of cancer cells and tissues, serving as an effective molecular probe for clinical cancer diagnosis .
Cat. No.: HY-136214
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R-BC154 acetate is a selective fluorescent α9β1 integrin antagonist. R-BC154 acetate acts as a useful high affinity, activation dependent integrin probe, which can be used to investigate α9β1 and α4β1 integrin binding activity .
Cat. No.: HY-172534
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BPN-01 is a fluorescent probe targeting translocator protein (TSPO) and human epidermal growth factor receptor 2 (HER2) with binding affinities of -10.7 kcal/mol for TSPO and -11.3 kcal/mol for HER2. BPN-01 is promising for research of solid tumor imaging during fluorescence image-guided surgery (FIGS) (Ex/Em = 475/510 nm) .
Cat. No.: HY-D2268A
Cat. No.: HY-147115
CAS No.: 79541-46-1
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4-Azidophlorizin is a high affinity probe and photoaffinity label for the glucose transporter in brush border membranes . 4-Azidophlorizin is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Cat. No.: HY-145699
CAS No.: 2248852-19-7
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UCSF686 is a probe with which to study the function of the 5-HT5AR. UCSF686 loses affinity at 5-HT5AR (>10 000 nM) but not at 5-HT1AR, 5-HT2BR, and 5-HT7R. UCSF686 controls for off-target effects .
Cat. No.: HY-173138
CAS No.: 3064236-41-2
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FCOB02 is a monoamine oxidase B (MAO-B) ligand. FCOB02 can be labeled as [18F]FCOB02, a 4-methylcoumarin-like targeting probe. [18F]FCOB02 has a high affinity for MAO-B with an IC50 of 10.68 nM. [18F]FCOB02 can be used in specific MAO-B imaging as well as quantitative analysis in vivo .
Cat. No.: HY-W205529
CAS No.: 87235-61-8
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RO 16-6491 Free base is a selective, reversible inhibitor of monoamine oxidase type B (MAO-B), exhibiting high affinity and specificity for binding sites in human frontal cortex mitochondria and platelet membranes. RO 16-6491 demonstrates a fast dissociation of bound radioactivity at 20 degrees C, indicating its dynamic binding properties. RO 16-6491 also acts as a substrate for MAO-B, suggesting that its oxidation may produce a stable intermediate responsible for its potent inhibitory effects. RO 16-6491 serves as an excellent radioligand probe for investigating the regional tissue distribution of MAO-B in various physiological and pathological states.
Cat. No.: HY-172666F
Synonyms: Biotin ceramide (d18:0/6:0)
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C6 Biotin dihydro ceramide is an affinity probe that allows C6 dihydro ceramide to be detected or immobilized through interaction with the biotin ligand.
Cat. No.: HY-175133
CAS No.: 257297-61-3
Synonyms: Biotin ceramide (t18:0/6:0)
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C6 Biotin phytoceramide (t18:0/6:0) is an affinity probe that allows C6 phytoceramide to be detected or immobilized through interaction with the biotin ligand .
Cat. No.: HY-P11785
CAS No.: 1192649-43-6
Cat. No.: HY-113331F
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Thromboxane B2-biotin is an affinity probe that allows detection of thromboxane B2 through an interaction with the biotin ligand. Thromboxane B2-biotin is designed to allow thromboxane B2 to be detected in complexes with protein binding partners .
Cat. No.: HY-185904
CAS No.: 1811556-65-6
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Desthiobiotin-FP is a covalent activity-based probe used for labeling, detecting and enriching active serine hydrolases in complex protein samples. Desthiobiotin-FP combines a fluorophosphonate (FP) reactive group with a desthiobiotin tag for affinity pull-down. Desthiobiotin-FP enables activity profiling of serine- and cysteine-based enzymes .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
