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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
102 Results for "
Affinity probe
" in MedChemExpress (MCE) Product Catalog:
Products (102)
102 Results for "Affinity probe" in MCE Product Catalog:
Cat. No.: HY-18909
CAS No.: 1157857-36-7
Multi-kinase-IN-11 (Compound 1a) is a DFG-out conformation-targeted multi-kinase inhibitor, including SRC, LCK, ABL, PYK2, CSK, HCK, P38 and C-KIT. Multi-kinase-IN-11 serves as a scaffold for the preparation of fluorescently labeled binding probes and affinity matrices .
Cat. No.: HY-107725R
CAS No.: 191868-14-1
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BIBO3304 (Standard) is the analytical standard of BIBO3304 (HY-107725). This product is intended for research and analytical applications. BIBO3304, a chemical probe, is a potent, orally active, and selective neuropeptide Y (NPY) Y1 receptor antagonist, with subnanomolar affinity for both the human and the rat Y1 receptor (IC50=0.38 and 0.72 nM, respectively) .
Cat. No.: HY-D3348
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Rhodamine picolyl azide is a fluorescent dye that enables visualization of protein labeling via click chemistry. The detection mechanism of Rhodamine picolyl azide is based on bioorthogonal click chemistry: Rhodamine picolyl azide reacts with the alkyne group on affinity-based protein profiling probes (ABPs) attached to labeled target proteins; this conjugation allows subsequent fluorescence imaging of proteins separated by SDS-PAGE .
Cat. No.: HY-W244412
CAS No.: 133081-27-3
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2,5-Dioxopyrrolidin-1-yl 6-hydrazinylnicotinate hydrochloride is an intermediate of a radionuclide molecular probe targeting the CD4 receptor. 2,5-Dioxopyrrolidin-1-yl 6-hydrazinylnicotinate hydrochloride serves as an imaging agent for heart transplant rejection. This CD4 probe is prepared by mixing leukocyte differentiation antigen 4 monoclonal antibody with a solution of 6-hydrazinylnicotinoyl succinimide ester hydrochloride, followed by extraction and reaction to obtain 6-hydrazinylnicotinate-leukocyte differentiation antigen 4 monoclonal antibody; this antibody is then mixed with N-tris (hydroxymethyl) glycine, stannous chloride and technetium for an oscillatory reaction. This CD4 probe exhibits high affinity for CD4 + T lymphocytes, along with the characteristics of high sensitivity and high specificity, enabling early diagnosis of acute rejection .
2-Hydroxyacetaldehyde acts as a ribonucleotide synthesis precursor and a LDL modifier. 2-Hydroxyacetaldehyde specifically targets lysine residues of high-affinity LDL receptors and their apolipoproteins. By blocking the ε-amino groups of apolipoproteins, 2-Hydroxyacetaldehyde prevents receptor recognition, thereby reducing LDL degradation by macrophages. 2-Hydroxyacetaldehyde generates modified LDL, which serves as a probe for investigating non-receptor-dependent catabolic pathways .
Cat. No.: HY-W248120
CAS No.: 1201643-08-4
Cat. No.: HY-DY1087
CAS No.: 874748-20-6
Solvent and concentration: DMSO: 2 mM
Cat. No.: HY-101418R
CAS No.: 1428327-31-4
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JNJ-47965567 (Standard) is the analytical standard of JNJ-47965567 (HY-101418). This product is intended for research and analytical applications. JNJ-47965567 is a centrally permeable, high-affinity, selective P2X7 antagonist, with pKis of 7.9 and 8.7 for human and rat P2X7, respectively. JNJ-47965567 can be used to probe the role of central P2X7 in rodent models of CNS pathophysiology .
Cat. No.: HY-D2962
Cat. No.: HY-184511
CAS No.: 2648041-73-8
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MODAG-005 is a blood-brain barrier-permeable PET probe precursor for α-synuclein (α‑Syn) aggregates, with a Ki value of 0.4 nM and a Kd value of 0.2 nM. MODAG-005 specifically binds to high-affinity sites within the tubular cavity of α-synuclein fibrils, and exhibits selectivity over tau protein fibrils and β-amyloid (A1-42) fibrils. MODAG-005 is applicable to the research of multiple system atrophy and Parkinson's disease .
Cat. No.: HY-D3303
Synonyms: 8-iso PGA2-biotin
Cat. No.: HY-110322AR
CAS No.: 1160271-30-6
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PPTN (Standard) is the analytical standard of PPTN (HY-110322A). This product is intended for research and analytical applications. PPTN, a chemical probe, is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a KB value of 434 pM. PPTN exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. Anti-inflammatory and immune activity .
Cat. No.: HY-P11618
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Cat. No.: HY-101189R
CAS No.: 1046447-90-8
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JNJ-39758979 (Standard) is the analytical standard of JNJ-39758979 (HY-101189). This product is intended for research and analytical applications. JNJ-39758979, a chemical probe, is a selective, orally active, and high-affinity histamine H4 receptor antagonist with Kis of 12.5, 5.3, and 25 nM for human, mouse, and monkey histamine H4 receptor, respectively. JNJ-39758979 functionally antagonizes histamine-induced cAMP inhibition with a pA2 of 7.9 in transfected cells. JNJ-39758979 shows good anti-inflammatory and antipruritic activity .
Cat. No.: HY-175083
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PtdIns-(4,5)-P2-biotin trisodium is a Biotin-labeled PtdIns-(4,5)-P2 analog. PtdIns-(4,5)-P2-biotin trisodium is an affinity probe of PI3Kγ. PI3Kγ can catalyse the phosphorylation of PtdIns-(4,5)-P2 at the 3′-OH group, giving rise to the second messenger PtdIns(3,4,5)-P3 .
Cat. No.: HY-186281
CAS No.: 2231747-83-2
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MAUra-DTB is a 1-methyl-4-arylurazole (MAUra) chemical probe conjugated with desthiobiotin, which preferentially labels tyrosine residues exposed on protein surfaces under photocatalytic or laccase-catalyzed conditions (). The desthiobiotin moiety of MAUra-DTB supports affinity enrichment based on streptavidin or NeutrAvidin. MAUra-DTB enables proteome-wide labeling in cell lysates, and after enrichment of labeled peptides by NeutrAvidin, the labeling sites can be identified via nanoLC-MS/MS. MAUra-DTB can be used for photocatalytic proximity labeling, target protein identification and proteomic studies .
Cat. No.: HY-165399
CAS No.: 145253-48-1
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RB104 is a highly selective neutral endopeptidase (NEP) inhibitor that exhibits extremely high affinity for Aplysia californica apNEP (Kd=0.16-0.26 pM) and rat NEP (Kd=7.0-26.8 pM). RB104 effectively blocks apNEP-mediated cleavage of Leu-enkephalin and shows minimal cross-reactivity with other zinc peptidases. Furthermore, RB104 can be iodinated or radiolabeled with 125I to serve as a probe, and is widely used in inhibitor gel electrophoresis, binding assays, Western blotting, and autoradiographic tissue localization, enabling sensitive detection of nanogram-level NEP in crude extracts and tissue sections .
Cat. No.: HY-128319
CAS No.: 497926-94-0
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KM822 is a dopamine transporter (DAT) inhibitor with an IC50 of 2.2 μM against hDAT and an IC50 of 10.4 μM against C. elegans DAT-1. KM822 binds to the allosteric A2 site in the extracellular vestibule of outward-facing DAT, reduces the affinity of psychostimulants and phenethylamine psychostimulants for DAT, and inhibits dopamine transport function. KM822 attenuates the behaviors induced by psychostimulants and phenethylamine psychostimulants in planarians and C. elegans, does not induce locomotor effects on its own, and exhibits specificity for DAT. KM822 can serve as a molecular probe for investigating the allosteric regulation of DAT function. KM822 is applicable to studies related to psychostimulant use disorders .
Cat. No.: HY-133240
CAS No.: 1109241-72-6
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trans-AzoTAB is a photoresponsive potassium/sodium/calcium channel modulator and DNA-binding agent. trans-AzoTAB undergoes trans-cis isomerization driven by light, with variable polarity and DNA affinity. trans-AzoTAB also enhances voltage-gated potassium currents and inhibits sodium and calcium currents in cardiomyocytes, thereby reducing spontaneous electrical activity and excitation conduction velocity. In addition, trans-AzoTAB induces compaction and frozen conformation of λ-phage DNA, and non-sequence-dependently inhibits transcription and translation processes in the dark; its activity can be reversed and restored by visible light after activation with ultraviolet irradiation. trans-AzoTAB can serve as a probe for two-photon optical regulation of myocardial excitability, and is used to construct photoresponsive interfacial polymer structures .
Cat. No.: HY-110374R
CAS No.: 1992047-61-6
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NVS-CECR2-1 (Standard) is the analytical standard of NVS-CECR2-1 (HY-110374). This product is intended for research and analytical applications. NVS-CECR2-1, a non-BET family Bromodomain (BRD) inhibitor, is a potent and selective cat eye syndrome chromosome region, candidate 2 (CECR2) inhibitor. NVS-CECR2-1 binds to CECR2 BRD with high affinity (IC50=47 nM; Kd=80 nM). NVS-CECR2-1 exhibits cytotoxic activity and induces apoptosis against various cancer cells by targeting CECR2 as well as via CECR2-independent mechanism . NVS-CECR2-1 is a chemical probe.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
