1201643-08-4
Chemical Structure
BD140
- CAS No.: 1201643-08-4
- Formula:C21H21BF2N2O
- Molecular Weight:366.21
IUPAC Name: heptylphosphonic acid
InChIKey: NDQRWYKJLFZGBK-RMKNXTFCSA-N
SMILES: [F-][B+3]1([N]2=CC=CC2=CC3=C(C)C=C([N-]31)/C=C/C4=CC=C(C=C4)OCCC)[F-]
Biological Activity: BD140 is a fluorescent probe with a binding affinity Kd of 4.1 μM for binding site 2 of human serum albumin (HSA). BD140 emits activated fluorescence upon binding to the specific HSA binding site 2. BD140 can be combined with dansylamide to form a fluorescent dye mixture, which is used for high-throughput mapping of interaction profiles of HSA drug binding sites (Ex/Em = 356/585 nm)[1][2][3].
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BD140 | BD140 is a fluorescent probe with a binding affinity Kd of 4.1 μM for binding site 2 of human serum albumin (HSA). BD140 emits activated fluorescence upon binding to the specific HSA binding site 2. BD140 can be combined with dansylamide to form a fluorescent dye mixture, which is used for high-throughput mapping of interaction profiles of HSA drug binding sites (Ex/Em = 356/585 nm). | |||||||||||||||||||||
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- [1]. Noriyoshi Ogino, et al. The identification of tyrosine-nitrated human serum albumin in airborne particulate matter from Japan. Atmospheric Pollution Research. Volume 12, Issue 5, May 2021, 101050.
- [2]. Er JC, et al. Fluorescent dye cocktail for multiplex drug-site mapping on human serum albumin. ACS Comb Sci. 2013 Sep 9;15(9):452-7. [Content Brief]
- [3]. Satomu Ishii, et al. Synthesis and biological evaluation of closo-dodecaborate ibuprofen conjugate (DIC) as a new boron agent for neutron capture therapy. Journal of Organometallic Chemistry. 19 February 20118.
Keywords
