2648041-73-8
Chemical Structure
MODAG-005
- CAS No.: 2648041-73-8
- Formula:C15H13BrN4
- Molecular Weight:329.19
InChIKey: RZOJJLBYVAAVPK-UHFFFAOYSA-N
SMILES: CNC1=CC=C(C=C1)C2=NNC(C3=CC=NC(Br)=C3)=C2
Biological Activity: MODAG-005 is a blood-brain barrier-permeable PET probe precursor for α-synuclein (α‑Syn) aggregates, with a Ki value of 0.4 nM and a Kd value of 0.2 nM. MODAG-005 specifically binds to high-affinity sites within the tubular cavity of α-synuclein fibrils, and exhibits selectivity over tau protein fibrils and β-amyloid (A1-42) fibrils. MODAG-005 is applicable to the research of multiple system atrophy and Parkinson's disease[1].
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MODAG-005 | MODAG-005 is a blood-brain barrier-permeable PET probe precursor for α-synuclein (α‑Syn) aggregates, with a Ki value of 0.4 nM and a Kd value of 0.2 nM. MODAG-005 specifically binds to high-affinity sites within the tubular cavity of α-synuclein fibrils, and exhibits selectivity over tau protein fibrils and β-amyloid (A1-42) fibrils. MODAG-005 is applicable to the research of multiple system atrophy and Parkinson's disease. | |||||||||||||||||||||
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Keywords
