2. Apoptosis
  3. Caspase
  4. NOTA-GZP

NOTA-GZP is a high-affinity, specific granzyme B-targeted irreversible inhibitory peptide PET imaging probe. NOTA-GZP can be used for the research of colon carcinoma, melanoma.

For research use only. We do not sell to patients.

NOTA-GZP

NOTA-GZP Chemical Structure

CAS No. : 2171121-32-5

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NOTA-GZP Related Antibodies

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Description

NOTA-GZP is a high-affinity, specific granzyme B-targeted irreversible inhibitory peptide PET imaging probe. NOTA-GZP can be used for the research of colon carcinoma, melanoma[1].

In Vitro

Non-radioactive gallium-labeled NOTA-GZP (30 min) inhibits activated human granzyme B with a Ki of 47 nM in a cell-free enzyme inhibition assay[1].
68Ga-NOTA-GZP (30 min) exhibits 5-11 fold specificity for activated human granzyme B over other granzyme family members and pro-granzyme B in a cell-free binding assay[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NOTA-GZP Related Antibodies
In Vivo

68Ga-NOTA-GZP (37 MBq; i.v.; single dose) PET imaging accurately reflects tumoral granzyme B expression in immunotherapy-treated colon cancer-bearing mice[1].
68Ga-NOTA-GZP (37 MBq; i.v.; single dose) PET imaging with a mean Tmax of 1.90 in high-uptake tumors completely predicts future tumor regression in combination immunotherapy-treated colon cancer-bearing mice prior to tumor size divergence[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/C mice (immunocompetent)[1]
Dosage: 37 MBq
Administration: i.v.; single dose
Result: Showed uptake in tumors, kidneys, and bladder.
Correlated highly with Western blot-quantified granzyme B expression.
Had an average tumor to blood ratio (TBR) of 1.29 in anti-PD-1 treated tumors.
Had an average TBR of 1.83 in combination therapy treated tumors.
Showed significantly elevated TBR above untreated mice (TBR=0.96) in both anti-PD-1 and combination therapy treated groups.
Confirmed PET analysis results via ex vivo gamma counting.\nSplit treated mice into two non-overlapping groups: high GZP uptake and low GZP uptake.
Showed high-uptake group was significantly different from low-uptake group and untreated controls.
Showed no significant TBR difference between low-uptake treated tumors and untreated controls.
Demonstrated equivalent tumor volumes across all groups at imaging time, but all high-uptake tumors subsequently regressed, while all low-uptake tumors progressed.
Molecular Weight

1142.24

Formula

C51H71N11O17S
CAS No.
Sequence

NOTA-β-Ala-Gly-Gly-Ile-Glu-Phe-Asp-CHO
Sequence Shortening

NOTA-β-AGGIEFD-CHO
SMILES

O=C(NCC(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(O)=O)C=O)=O)=O)=O)=O)=O)CCNC(NC(C=C2)=CC=C2CC3CN(CC(O)=O)CCN(CC(O)=O)CCN3CC(O)=O)=S
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NOTA-GZP Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NOTA-GZP2171121-32-5Caspasegranzyme family membersgranzyme Bimmunotherapymelanomacolon carcinomacolon cancer-bearing micepro-granzyme Bhuman granzyme BInhibitorinhibitorinhibit

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