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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
100 Results for "
AR PROTAC
" in MedChemExpress (MCE) Product Catalog:
Products (100)
100 Results for "AR PROTAC" in MCE Product Catalog:
Cat. No.: HY-173373
CAS No.: 2156591-18-1
Research Areas:
AR ligand-39, an androgen receptor (AR) ligand, is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). AR ligand-39 can be used for synthesis PROTAC AR Degrader-10 (HY-173372) .
Cat. No.: HY-169967
Research Areas:
AR ligand-31 is a PROTAC target protein ligand that can be used to synthesize PROTAC AR Degrader-5 (HY-160547) .
Cat. No.: HY-170449
Target:
Research Areas:
E3 ligase Ligand 48 is a CRBN ligand for PROTAC AR Degrader-9 (HY-170448). PROTAC AR Degrader-9 (Compound c6) is a PROTAC degrader for androgen receptor, that degrades AR in human hair follicle papilla cells (HDPCs) with a DC50 of 262.38 nM .
Cat. No.: HY-176129
Research Areas:
AR ligand 41 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). AR ligand 41 can be used for the synthesis of BWA-6047 (HY-176128) .
Cat. No.: HY-175456
CAS No.: 3108871-05-9
Research Areas:
AR-DBD ligand-1 is an AR-DBD ligand. AR-DBD ligand-1 can be used to synthesize PROTAC LYA914 (HY-175455) .
Cat. No.: HY-170303
CAS No.: 2505498-74-6
Research Areas:
AR ligand-32 is a target protein ligand, used for the synthesis of PROTAC AR Degrader-7 (HY-160221) .
Cat. No.: HY-172624
CAS No.: 2757424-54-5
Research Areas:
AR antagonist 14 is is a PROTAC target protein ligand (Ligands for Target Protein for PROTAC). AR antagonist 14 can be combined with VH 101-amide-piperidine-Pip-alkyne (HY-172625) to synthesize PROTAC degraders (ARD-69 (HY-114402)) .
Cat. No.: HY-175457
Research Areas:
AR-DBD ligand-Linker Conjugate 1 is a conjugate of AR-DBD ligand and linker. AR-DBD ligand-Linker Conjugate 1 can be used to synthesize PROTAC LYA914 (HY-175455) .
Cat. No.: HY-170450
Research Areas:
AR ligand-38 is the ligand for androgen receptor, that can be used for synthesis of PROTAC AR Degrader-9 (HY-170448) .
Cat. No.: HY-401056
CAS No.: 3032602-27-7
Target:
Research Areas:
BWA-522 intermediate-3 is a BWA-522 intermediate. BWA-522 is an orally available small molecule protein-targeting chimera (PROTACs) with significant degradation effect on AR-FL and AR-V7 .
Cat. No.: HY-172954
CAS No.: 3077430-87-3
Research Areas:
Androgen receptor ligand 1 is an androgen receptor (AR) ligand. Androgen receptor ligand 1 binds to CRBN E3 ligase via a linker to form an AR PROTAC degrader. Androgen receptor ligand 1 can be used in the study of prostate cancer .
Cat. No.: HY-168697
Research Areas:
AR ligand-37 is a PROTAC target protein ligand that can be used to synthesize BMS-986365 (HY-158101) .
Cat. No.: HY-400666A
Research Areas:
AR ligand-44 TFA is an androgen receptor ligand that can be used in the synthesis of PROTACs, such as ARD-2051 (HY-149862) .
Cat. No.: HY-170304
CAS No.: 2505504-49-2
Target:
Research Areas:
E3 ligase Ligand 44 is a ligand for E3 ligase, used for the synthesis of PROTAC AR Degrader-7 (HY-160221) .
Cat. No.: HY-184195
Research Areas:
PROTAC AR Degrader-13 is a proteolysis-targeting chimera (PROTACs) that targets the androgen receptor (AR). PROTAC AR Degrader-13 has a DC50 of 0.90 nM in LNCaP cells and a DC50 of 0.23 nM in hDPC cells. PROTAC AR Degrader-13 induces AR degradation, downregulates TGF-β1 expression, upregulates β-catenin levels, and restores the Wnt/β-catenin pro-proliferation signaling in hair follicles. In a testosterone-induced androgenetic alopecia mouse model, PROTAC AR Degrader-13 accelerates hair regeneration rate, increases hair density and hair diameter. PROTAC AR Degrader-13 can be used for the research of androgenetic alopecia .
Cat. No.: HY-169966
CAS No.: 1973409-82-3
Target:
Research Areas:
Boc-CH2-O-(CH2)4-OTs is a PROTAC linker. Boc-CH2-O-(CH2)4-OTs can be used to synthesize PROTAC AR Degrader-5 (HY-160547) .
Cat. No.: HY-W1003189
CAS No.: 2753651-18-0
Target:
Research Areas:
E3 ligase Ligand 42 is an E3 ubiquitin ligase ligand. E3 ligase Ligand 42 can be connected to the target protein ligand through a linker and can be used to synthesize PROTAC AR Degrader-6 (HY-156751). PROTAC can induce ubiquitination degradation of cancer-promoting proteins .
Cat. No.: HY-169975
CAS No.: 2566692-49-5
Target:
Research Areas:
tert-Butyl 4-(4-(piperazin-1-ylmethyl)piperidin-1-yl)benzoate is a PROTAC linker. tert-Butyl 4-(4-(piperazin-1-ylmethyl)piperidin-1-yl)benzoate can be used to synthesize PROTAC AR Degrader-6 (HY-156751) .
Cat. No.: HY-L129
128 compounds
Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation. PROTACs consist of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand (mostly small-molecule inhibitor) for protein of interest（target binder）. Upon binding to the target protein, the PROTACs can recruit E3 for target protein ubiquitination, which is subjected to proteasome-mediated degradation. Therefore, PROTACs execute their functions by degrading the target proteins rather than inhibiting them, which has a great superiority in overcoming resistance caused by target mutation or overexpression. To date, PROTAC technology has been applied to a variety of targets, including AR, ER, BTK, BET, and BCR-ABL to overcome resistance.
MCE carefully prepared a unique collection of 128 ligands for target proteins, which have been reported to be used in PROTAC design. MCE Target Protein Ligand Library is a useful tool for PROTAC development.
Cat. No.: HY-179442
CAS No.: 1318208-88-6
Research Areas:
AR ligand-48 is an AR (Androgen Receptor) inhibitor and a ligand for the target protein for PROTAC (AR). AR ligand-48 can be used to synthesize PROTAC AR Degrader-12 (HY-179433) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
