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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
88 Results for "
Map4
" in MedChemExpress (MCE) Product Catalog:
Products (88)
88 Results for "Map4" in MCE Product Catalog:
Cat. No.: HY-145044
CAS No.: 2403600-07-5
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HPK1-IN-17 is a potent and selective inhibitor of HPK1. Hematopoietic progenitor kinase 1 (HPKl) originally cloned from hematopoietic progenitor cells is a member of MAP kinase kinase kinase kinases (MAP4Ks) family. HPK1-IN-17 is useful in researching, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer (extracted from patent WO2019238067A1, compound 73) .
Cat. No.: HY-179111
CAS No.: 3034320-17-4
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HPK1-IN-64 is a potent, selective, and orally active HPK1 inhibitor with an IC50 value of 1.9 nM. HPK1-IN-64 exhibits selectivity exceeding 100-fold, 80-fold, 300-fold, and 350-fold against off-target kinases such as GLK, MAP4K5, TBK1, and TNIK, respectively. HPK1-IN-64 inhibits SLP76 protein phosphorylation and IL-2 secretion. HPK1-IN-64 may be used in cancer research, such as for colorectal cancer .
Cat. No.: HY-159905
CAS No.: 3048537-48-7
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HPK1-IN-54 is a potent HPK1 (Hematopoietic Progenitor Kinase 1) inhibitor that enhances T cell activation and proliferation by inhibiting HPK1 activity, thereby exhibiting antitumor effects. Its IC50 value against HPK1 is 2.67 nM, with excellent selectivity over the MAP4K family (>100-fold) and other selected kinases (>300-fold). HPK1-IN-54 displayed moderate in vivo clearance and reasonable oral exposure in mice and rats. Additionally, HPK1-IN-54 demonstrated strong antitumor efficacy in a CT26 murine colon cancer model and synergistic effects when combined with anti-PD-1 (HY-P9902A). HPK1-IN-54 shows promise for research in the field of immunotherapy .
Cat. No.: HY-W402208
CAS No.: 1499162-60-5
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MAP4K4-IN-7 (Compound 8) is a MAP4K4 inhibitor. MAP4K4-IN-7 shows moderate inhibitory activity against TNIK, MAP4K4, and MINK1 with pIC50 values of 6.8, 6.8, and 6.7 respectively. MAP4K4-IN-7 can be used for the researches of cancer and neurological disease, such as schizophrenia .
Cat. No.: HY-111754R
CAS No.: 2306178-56-1
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DMX-5804 (Standard) is the analytical standard of DMX-5804 (HY-111754). This product is intended for research and analytical applications. DMX-5804 is a potent, orally active and selective MAP4K4 inhibitor, with an IC50 of 3 nM, a pIC50 of 8.55 for human MAP4K4, less potent on MINK1/MAP4K6 (pIC50, 8.18), and TNIK/MAP4K7 (pIC50, 7.96). DMX-5804 enhances cardiomyocyte survival, and reduces ischemia-reperfusion injury in mice .
Cat. No.: HY-123965
CAS No.: 2089334-01-8
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PF-06745013 (Compound 37) is a MAP4K4 inhibitor without time-dependent inhibition (TDI) risk of CYP3A4 (IC50 of 0.4 nM for MAP4K4). PF-06745013 has no accumulation CNS-impaired and non-ATP competitive activities in mouse models. PF-06745013 can be used for inflammatory diseases like diabetes and cancers research .
Cat. No.: HY-P702743
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: Map4K4; Non-Specific Serine/Threonine Protein Kinase; Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4; Epididymis Secretory Protein Li 31; HGK; Ste20 Group Protein Kinase HGK; NIK; Uncharacterized Protein Map4K4; FLH21957; HPK/GCK-Like Kinase; Hep
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-100343R
CAS No.: 1449277-10-4
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GNE-495 (Standard) is the analytical standard of GNE-495 (HY-100343). This product is intended for research and analytical applications. GNE-495 is a potent and selective MAP4K4 inhibitor with an IC50 of 3.7 nM.
Cat. No.: HY-W003471
CAS No.: 159326-68-8
Pyrrolo[2,1-f][1,2,4]triazin-4-amine is a MAP4K4 inhibitor with a surface plasmon resonance (SPR) Kd of 88 μM and a ligand efficiency of 0.56 .
Cat. No.: HY-187930
CAS No.: 2965385-11-7
HPK1-IN-72 is an orally active and selective HPK1/MAP4K1 inhibitor with an IC50 of 52.4 nM against human targets. HPK1-IN-72 inhibits HPK1 activation, blocks the negative regulation of T cell receptor signaling, restores T cell receptor signal transduction and enhances T cell function. HPK1-IN-72 suppresses tumor growth, exhibits potent single-agent anti-tumor efficacy, and also produces synergistic effects with anti-PD-1 antibodies or anti-PD-L1/IL-15 immunocytokine prodrugs. HPK1-IN-72 can be used in research related to breast cancer, colorectal cancer and prostate cancer .
Cat. No.: HY-P81378A
Synonyms: Map4K4; HGK, KIAA0687, NIK; Mitogen-activated protein kinase kinase kinase kinase 4; HPK/GCK-like kinase HGK; MapK/ERK kinase kinase kinase 4 (MEK kinase kinase 4; MEKKK 4); Nck-interacting kinase
Cat. No.: HY-P76946
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: Map4K2; B Lymphocyte Serine/Threonine Protein Kinase; Prev. RAB8IP; Non-Specific Serine/Threonine Protein Kinase; GCK; Germinal Centre Kinase (GC Kinase); BL44; Rab8 Interacting Protein; MapK/ERK Kinase Kinase Kinase 2; Rab8-Interacting Protein; MEK Kinas
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P703250
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: Map4K3; MEK Kinase Kinase 3; Prev. RAB8IPL1; Mitogen-Activated Protein Kinase Kinase Kinase Kinase; GLK; Non-Specific Serine/Threonine Protein Kinase; MapKKKK3; Germinal Center Kinase-Like Kinase; Germinal Center Kinase-Related Protein Kinase; Uncharacter
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P706070
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: Map4K1; MEK Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1; MEKKK 1; HPK1; Mitogen-Activated Protein Kinase Kinase Kinase Kinase; Hematopoietic Progenitor Kinase 1; Non-Specific Serine/Threonine Protein Kinase; MapK/ERK Kinase Ki
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P706071
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: Map4K5; Germinal Center Kinase-Related; Mitogen-Activated Protein Kinase Kinase Kinase Kinase 5; MEK Kinase Kinase 5; KHS; MEKKK 5; Kinase Homologous To SPS1/STE20; Mitogen-Activated Protein Kinase Kinase Kinase Kinase; KHS1; Non-Specific Serine/Threonine
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
