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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
78 Results for "
polymorphonuclear
" in MedChemExpress (MCE) Product Catalog:
Products (78)
78 Results for "polymorphonuclear" in MCE Product Catalog:
Cat. No.: HY-129905R
CAS No.: 6491-83-4
Synonyms: LLOMe hydrobromide (Standard); Leu-Leu methyl ester hydrobromide (Standard); H-Leu-Leu-OMe hydrobromide (Standard)
Category:
Cat. No.: HY-129905AR
CAS No.: 16689-14-8
Synonyms: LLOMe hydrobromide (Standard); Leu-Leu methyl ester hydrobromide (Standard); H-Leu-Leu-OMe hydrobromide (Standard)
Category:
Cat. No.: HY-P72179
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ELANE; polymorphonuclear Leukocyte Elastase; Prev. ELA2; Elastase 2, Neutrophil; HLE; Leukocyte Elastase; Neutrophil Elastase; Elastase-2; PMN Elastase; Granulocyte-Derived Elastase; Medullasin; polymorphonuclear Elastase; PMN-E; Human Leukocyte Elastase
Species:
Human
Source:
E. coli
Cat. No.: HY-187671
CAS No.: 59756-39-7
Target:
Research Areas:
Enolicam sodium is a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), with a COX IC50 of 1.5 μM and a 5-LOX IC50 of 3.5 μM. Enolicam sodium inhibits arachidonic acid metabolism via the COX and 5-LOX pathways. Enolicam sodium inhibits the production of reactive oxygen species (ROS), superoxide anions, hydrogen peroxide, and the release of polymorphonuclear leukocytes. Enolicam sodium is applicable to research related to acute oxidative lung injury and ocular inflammation .
Cat. No.: HY-19014
CAS No.: 83677-24-1
Target:
Research Areas:
KME-4 is an orally active dual inhibitor of 5-lipoxygenase (5-lipoxygenase) and cyclooxygenase (cyclooxygenase). KME-4 inhibits 5-lipoxygenase in the cytosol of guinea pig polymorphonuclear leukocytes (PMNL) and cyclooxygenase in rabbit platelets, with IC50 values of 0.85 μM and 0.44 μM, respectively. KME-4 can be used in studies related to arachidonic acid metabolism, inflammatory responses, and arthritis .
Cat. No.: HY-W751362
CAS No.: 14176-10-4
Target:
Research Areas:
Cetiedil is a vasodilator and potassium channel blocker with anti-sickle cell and analgesic activities. Cetiedil increases cyclic adenosine monophosphate levels, relaxes vascular smooth muscle, and blocks the action of Bradykinin (HY-P0206). Cetiedil inhibits platelet aggregation, reduces plasma fibrinogen concentration and blood viscosity, suppresses sickling of sickle red blood cells and improves their filterability, and decreases irreversible sickle cells. Cetiedil binds to calmodulin, inhibits Ca 2+-dependent potassium permeability of erythrocyte membranes, increases sodium permeability of erythrocytes, and regulates polymorphonuclear leukocyte function. Cetiedil can be used in research related to intermittent claudication, arteriosclerosis obliterans, diabetic arteriosclerosis, Raynaud's disease, angina pectoris, and sickle cell anemia .
Cat. No.: HY-121683A
CAS No.: 3163-37-9
Synonyms: (E/Z)-16:1 Aldehyde
Research Areas:
2-Hexadecenal, a long-chain fatty aldehyde, is a byproduct of sphingolipid metabolism, involved in cytoskeletal reorganization, DNA damage, and apoptosis. 2-Hexadecenal regulates ROS production and induces apoptosis in polymorphonuclear leucocytes.
Cat. No.: HY-157253
CAS No.: 1217458-58-6
Target:
Research Areas:
13(S)-HODE is the lipoxygenase metabolite of Linoleic acid (HY-N0729). 13(S)-HODE modulates the platelet-activating factor, leukotriene B4, and formyl-Met-Leu-Phe-induced calcium influx in human polymorphonuclear leukocytes.
Cat. No.: HY-W923355
CAS No.: 99660-94-3
Synonyms: EPA-TG; Glycerol trieicosapentaenoate; TG(20:5/20:5/20:5)
1,2,3-Trieicosapentaenoyl glycerol (EPA-TG) is a glycerol ester that can be obtained by the reaction of polyunsaturated fatty acids or lower alkyl esters with glycerol catalyzed by alkoxide ions . After two intravenous injections of the EPA-TG emulsion into rabbits, the EPA content in plasma and platelet phospholipids increased markedly . In another study, by administering the EPA-TG emulsion, the production of leukotriene B4 by polymorphonuclear leukocytes in rabbits was reduced by 40% .
Cat. No.: HY-106463
CAS No.: 24645-20-3
Target:
Research Areas:
Hexaprofen is a 2-arylpropionic acid derivative. Hexaprofen inhibits CXCL8-induced chemotaxis, while no activity is detected against CXCL1-induced chemotaxis .
Cat. No.: HY-N21989
CAS No.: 1620808-64-1
Synonyms: Kaempferol 3-O-β-D-glucopyranosyl-(1→3)[α-L-rhamnopyranosyl(1→6)]-(2-O-E-p-coumaroyl-β-D-glucopyranoside)
Target:
Cat. No.: HY-145474
CAS No.: 937738-64-2
Target:
Research Areas:
17(R)-Resolvin D1 methyl ester is the methyl ester of Resolvin D1 (RvD1) (HY-125527) induced by Aspirin (HY-14654) with the 17R epimer (AT-RvD1). RvD is a regulator of transendothelial migration of human polymorphonuclear leukocytes and an anti-inflammatory agent. The 17R-trihydroxy-4Z of RvD1 also blocks transendothelial migration of human neutrophils (EC50 approximately 30 nM). AT-RvD1 is an effective form that protects against the rapid inactivation of Resolvin D1 .
Cat. No.: HY-P81215
Synonyms: Bone Marrow Serine Protease; ELA 2; ELA2; ELANE; Elastase 2; Elastase-2; Elastase 2 neutrophil; Elastase neutrophil expressed; Elastase-2; ELNE_HUMAN; GE antibody Granulocyte derived elastase; HLE; HNE; Human leukocyte elastase; Leukocyte elastase; Leukocyte Elastase Precursor; Medullasin; NE; Neutrophil elastase; Neutrophill elastase; PMN E; PMN Elastase; polymorphonuclear elastase; SCN1; Serine protease; SERP1.
Cat. No.: HY-15651B
CAS No.: 1240425-11-9
Synonyms: AZD9668 hydrochloride
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
Alvelestat hydrochloride (AZD9668 hydrochloride) is an orally active, selective inhibitor of neutrophil elastase. Alvelestat hydrochloride reduces elastase activity, myeloperoxidase release, neutrophil recruitment and activation, and calcium phosphate precipitation; promotes smooth muscle cell colonization and collagen deposition; and inhibits the formation of neutrophil extracellular traps (NETs) as well as NET-derived neutrophil elastase activity. Alvelestat hydrochloride restores endothelial dysfunction, regulates antioxidant factors, improves the expression of endothelial tight junctions, reduces vascular leakage, and accelerates wound healing. Alvelestat hydrochloride prevents pulmonary hemorrhage, matrix protein degradation, airspace enlargement, and small airway wall remodeling; and alleviates cigarette-induced inflammatory responses. Alvelestat hydrochloride inhibits the growth of abdominal aortic aneurysms exacerbated by Porphyromonas gingivalis. Alvelestat hydrochloride can be used in research related to chronic obstructive pulmonary disease, abdominal aortic aneurysm, radiation-induced skin injury, and bronchiectasis .
Cat. No.: HY-124183
CAS No.: 1240494-14-7
Target:
Research Areas:
SX-576 is a CXCR1 and CXCR2 antagonist with IC50 values of 31 nM and 21 nM, respectively. SX-576 inhibits neutrophil infiltration in a rat model of pulmonary inflammation. SX-576 can be used in studies related to pulmonary inflammation .
Cat. No.: HY-D3330
Cat. No.: HY-125089
CAS No.: 1233114-22-1
Target:
Research Areas:
AM-643 is a FLAP inhibitor with human IC50 of 2 nM, oral activity, and dermal activity.AM-643 selectively inhibits FLAP, reduces leukotriene biosynthesis and reduces inflammatory ear swelling.AM-643 can be used for the research of skin disorders involving leukotriene production .
Cat. No.: HY-P11791
CAS No.: 1644397-65-8
Target:
Research Areas:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
