Enolicam sodium
Enolicam sodium is a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), with a COX IC50 of 1.5 μM and a 5-LOX IC50 of 3.5 μM. Enolicam sodium inhibits arachidonic acid metabolism via the COX and 5-LOX pathways. Enolicam sodium inhibits the production of reactive oxygen species (ROS), superoxide anions, hydrogen peroxide, and the release of polymorphonuclear leukocytes. Enolicam sodium is applicable to research related to acute oxidative lung injury and ocular inflammation.
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- CAS No.: 59756-39-7
- Formule: C17H11Cl3NNaO4S
- Masse moléculaire:454.69
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
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COX 1.5 μM (IC50) |
5-LOX 3.5 μM (IC50) |
In Vitro
Enolicam (0.1 mM; 16-70 min) sodium moderately inhibits reactive oxygen species generation by 24-hour mouse peritoneal exudate cells in both Lucigenin (HY-D0720)- and Luminol (HY-15922)-amplified chemiluminescence assays[1].
Enolicam sodium potently inhibits cyclooxygenase (IC50 = 1.5 μM) and 5-lipoxygenase (IC50 = 3.5 μM) in a cell-free biochemical assay[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 59756-39-7
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Masse moléculaire 454.69
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Formule C17H11Cl3NNaO4S
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SMILES
O=C(C1=C(C2=C(S(=O)(CC1)=O)C=CC(Cl)=C2)O[Na])NC3=CC=C(C(Cl)=C3)Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Enolicam sodium Related Classifications
HY-187671 Related Classifications
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