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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
879 Results for "
binding affinity
" in MedChemExpress (MCE) Product Catalog:
Products (879)
879 Results for "binding affinity" in MCE Product Catalog:
Nitrate Reductase (NAD[P]H), Pichia pastoris (recombinant) is a simplified version of nitrate reductase S-NaR1 expressed and purified by Pichia pastoris. Nitrate Reductase (NAD[P]H), Pichia Pastoris (recombinant) contains sites binding molybdenum-molybdenopyridine (Mo-MPT) and nitrate reduction active sites and only contains two domains instead of the five domains of the complete NaR. This simplified form of nitrate reductase was expressed in high density in P. pastoris and purified to homogeneity in one step by fixed metal affinity chromatography (IMAC). Nitrate Reductase (NAD[P]H), Pichia Pastoris (recombinant) can be used in the development of biosensors and environmental monitoring .
Cat. No.: HY-W007223
CAS No.: 4350-07-6
Synonyms: D-5-HTP; 5-Hydroxy-D-tryptophan
Target:
Research Areas:
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3-Methoxyphenol (Standard) is the analytical standard of 3-Methoxyphenol (HY-Y1840). This product is intended for research and analytical applications. 3-Methoxyphenol is an environmental pollutant. 3-Methoxyphenol occurs in the aroma components of dried bonito. 3-Methoxyphenol potentially enhances GABA-evoked responses of α1β1 GABAA receptors by increasing the affinity of GABA binding sites. 3-Methoxyphenol is used as a flavoring substance in food and animal feed. 3-Methoxyphenol prolongs pentobarbital-induced sleeping time and reduces elevated plus maze behavior .
Cat. No.: HY-Y1840S
CAS No.: 104714-88-7
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3-Methoxyphenol-d3 is the d3-labeled 3-Methoxyphenol (HY-Y1840). 3-Methoxyphenol is an environmental pollutant. 3-Methoxyphenol occurs in the aroma components of dried bonito. 3-Methoxyphenol potentially enhances GABA-evoked responses of α1β1 GABAA receptors by increasing the affinity of GABA binding sites. 3-Methoxyphenol is used as a flavoring substance in food and animal feed. 3-Methoxyphenol prolongs pentobarbital-induced sleeping time and reduces elevated plus maze behavior .
Cat. No.: HY-Z12208
CAS No.: 1305124-48-4
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Cat. No.: HY-P991745
Cat. No.: HY-W043748
CAS No.: 38862-24-7
Synonyms: N-Succinimidyl acrylate
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2,5-Dioxopyrrolidin-1-yl acrylate (N-Succinimidyl acrylate) is a lysine residue modifier and coupling monomer. 2,5-Dioxopyrrolidin-1-yl acrylate covalently modifies the primary amines of lysine residues on monoclonal anti-horseradish peroxidase IgG antibodies, neutralizes positive charges and replaces them with low-affinity acrylate groups. 2,5-Dioxopyrrolidin-1-yl acrylate inhibits the formation of rapid hard coronas on citrate-coated gold nanoparticles, induces antibody unfolding and loss of antigen-binding function, but does not affect the antigen-binding function of antibodies in free solution. 2,5-Dioxopyrrolidin-1-yl acrylate reacts with the ε-amino groups on lysine residues of L-asparaginase, introduces vinyl groups and generates N-hydroxysuccinimide. 2,5-Dioxopyrrolidin-1-yl acrylate regulates the activity of L-asparaginase .
Cat. No.: HY-P72748
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FCER2; Immunoglobulin E-binding Factor; Prev. CD23A; Lymphocyte IgE Receptor; Prev. FCE2; Fc-Epsilon-RII; CLEC4J; BLAST-2; FcepsilonRII; IGEBF; CD23 Antigen; Fc Fragment Of IgE, Low affinity II, Receptor For (CD23A); FCErII; C-Type Lectin Domain Family 4,
Species:
Human
Source:
HEK293
Cat. No.: HY-P74320
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FCER2; Immunoglobulin E-binding Factor; Prev. CD23A; Lymphocyte IgE Receptor; Prev. FCE2; Fc-Epsilon-RII; CLEC4J; BLAST-2; FcepsilonRII; IGEBF; CD23 Antigen; Fc Fragment Of IgE, Low affinity II, Receptor For (CD23A); FCErII; C-Type Lectin Domain Family 4,
Species:
Rat
Source:
HEK293
Cat. No.: HY-P74321
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FCER2; Immunoglobulin E-binding Factor; Prev. CD23A; Lymphocyte IgE Receptor; Prev. FCE2; Fc-Epsilon-RII; CLEC4J; BLAST-2; FcepsilonRII; IGEBF; CD23 Antigen; Fc Fragment Of IgE, Low affinity II, Receptor For (CD23A); FCErII; C-Type Lectin Domain Family 4,
Species:
Mouse
Source:
HEK293
Cat. No.: HY-10211S
Synonyms: 17-AAG-d5; NSC 330507-d5; CP 127374-d5
Synonyms: LY170053-d3
Cat. No.: HY-14993R
CAS No.: 245520-69-8
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SCH79797 (Standard) is the analytical standard of SCH79797. This product is intended for research and analytical applications. SCH79797 is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist. SCH79797 inhibits binding of a high-affinity thrombin receptor-activating peptide to PAR1 with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 inhibits thrombin-induced platelet aggregation with an IC50 of 3 μM. SCH79797 has antiproliferative and pro-apoptotic effects, and limits myocardial ischemia/reperfusion injury in rat hearts. SCH79797 also potently prevents PAR1 activation in vascular smooth muscle cells, endothelial cells, and astrocytes .
Cat. No.: HY-14994R
CAS No.: 1216720-69-2
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SCH79797 (dihydrochloride) (Standard) is the analytical standard of SCH79797 (dihydrochloride). This product is intended for research and analytical applications. SCH79797 dihydrochloride is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist. SCH79797 dihydrochloride inhibits binding of a high-affinity thrombin receptor-activating peptide to PAR1 with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 dihydrochloride inhibits thrombin-induced platelet aggregation with an IC50 of 3 μM. SCH79797 dihydrochloride has antiproliferative and pro-apoptotic effects, and limits myocardial ischemia/reperfusion injury in rat hearts. SCH79797 dihydrochloride also potently prevents PAR1 activation in vascular smooth muscle cells, endothelial cells, and astrocytes .
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Keap1-Nrf2-IN-13 is a Keap1-Nrf2 protein–protein interaction (PPI) inhibitor with an IC50 value of 0.15 μM. Keap1-Nrf2-IN-13 has strong binding affinities to the Keap1 protein by forming hydrogen bond with the key polar residues (Asn414, Arg415, Arg483, Gln530). Keap1-Nrf2-IN-13 can be used in the research of oxidative stress-related and inflammatory diseases, including pulmonary fibrosis, chronic obstructive pulmonary disorder (COPD) and cancers .
Cat. No.: HY-165399
CAS No.: 145253-48-1
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RB104 is a highly selective neutral endopeptidase (NEP) inhibitor that exhibits extremely high affinity for Aplysia californica apNEP (Kd=0.16-0.26 pM) and rat NEP (Kd=7.0-26.8 pM). RB104 effectively blocks apNEP-mediated cleavage of Leu-enkephalin and shows minimal cross-reactivity with other zinc peptidases. Furthermore, RB104 can be iodinated or radiolabeled with 125I to serve as a probe, and is widely used in inhibitor gel electrophoresis, binding assays, Western blotting, and autoradiographic tissue localization, enabling sensitive detection of nanogram-level NEP in crude extracts and tissue sections .
Cat. No.: HY-176501
CAS No.: 3036243-81-6
FKBP12 ligand-2 (compound d) is a high affinity ligand targeting FKBP12. FKBP12 ligand-2 can be used to selectively enhance the binding of heterobifunctional molecules to BRD4, enriching the drug intracellularly through the "CellTrap" effect to form a ternary complex of FKBP12-ligand-BRD4. This ternary complex has inhibitory activity against BRD4, thereby inhibiting the expression of BRD4 target genes (such as MYC) and inducing tumor cell death. FKBP12 ligand-2 can be used for selective cancer research based on differences in intracellular presenter protein levels .
Cat. No.: HY-176502
CAS No.: 3036374-26-9
FKBP12 ligand-3 (compound dj) is a high-affinity ligand targeting FKBP12. FKBP12 ligand-3 can be used to selectively enhance the binding of heterobifunctional molecules to BRD4, enriching the drug intracellularly through the "CellTrap" effect to form a ternary complex of FKBP12-ligand-BRD4. This ternary complex has inhibitory activity against BRD4, thereby inhibiting the expression of BRD4 target genes (such as MYC) and inducing tumor cell death. FKBP12 ligand-3 can be used for selective cancer research based on differences in intracellular presenter protein levels .
Cat. No.: HY-176546
Target:
Research Areas:
NK3R-IN-2 is an orally active NK3R inhibitor with an IC50 of 330.50 nM for human NK3R. NK3R-IN-2 can pass through the blood-brain barrier. NK3R-IN-2 has excellent NK3R binding affinity (IC50 = 87.31 nM) in CHO-K1 cells. NK3R-IN-2 effectively inhibits the level of luteinizing hormone (LH). NK3R-IN-2 can be used for research on hormone related conditions .
Cat. No.: HY-180526
CAS No.: 2055901-03-4
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PDE2A-IN-2 is a selective and brain-penetrant PDE2A inhibitor (Ki = 5.49 nM and 100 > fold selectivity over other PDE isoforms). The 11C-labeled PDE2A-IN-2 serves as a positron emission tomography (PET) tracer for brain imaging in patients with neurodegenerative diseases. PDE2A-IN-2 educes the radiotracer signal in PDE2A-rich regions in vitro. PDE2A-IN-2 exhibits low binding affinity in vivo. PDE2A-IN-2 can be used for neurodegenerative diseases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
