99 Results for "

Polyketide

" in MedChemExpress (MCE) Product Catalog:
Products (99)

99 Results for "Polyketide" in MCE Product Catalog:

Cat. No.: HY-183968
Target:  

Bacterial

Research Areas:  

Infection

BRD1554 is an inhibitor of the thioesterase domain of polyketide synthase 13 (Pks13) from Mycobacterium tuberculosis, and exhibits selective activity against Pks13-expressing strains. Pks13 is a polyketide synthase essential for the synthesis of branched-chain fatty acids in mycobacteria. BRD1554 serves as a scaffold molecule for anti-Mycobacterium tuberculosis agents. BRD1554 can be used in the research of tuberculosis .
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Cat. No.: HY-117740
CAS No.: 1257083-94-5
Target:  

Others

Heronamide C is a polyketide macrolactam isolated from marine Streptomyces that has the activity of producing reversible non-cytotoxic effects on mammalian cell morphology.
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Cat. No.: HY-N19212
CAS No.: 3040055-59-9
Target:  

Bacterial

Glenthmycin A is a macrocyclic type II spiroketal polyketide antibacterial agent. Glenthmycin A inhibits the growth of Gram-positive pathogens. Glenthmycin A is applicable to the research of bacterial infections .
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Cat. No.: HY-N20681
CAS No.: 168146-21-2
Evofolin A is a conjugated benzophenone derivative and monocyclic polyketide that exists in the heartwood of Phellodendron chinense var. glabriusculum, the herb Sida acuta, and the filamentous fungus Aspergillus oryzae. Evofolin A acts as an inducer of quinone reductase activity in cultured hepatoma cells .
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Cat. No.: HY-E71645
Research Areas:  

Others

3,5-Dihydroxybiphenyl synthase (EC 2.3.1.177) is a polyketide synthase that is involved in the production of the phytoalexin aucuparin. 2-Hydroxybenzoyl-CoA can also act as substrate but it leads to the derailment product 4-hydroxycoumarin (cf.
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Cat. No.: HY-N19242
CAS No.: 877060-85-0
F2928-1 is a small-molecule polyketide antifungal antibiotic. F2928-1 can kill harmful fungi such as Aspergillus fumigatus. F2928-1 can be used in studies related to aspergillosis and candidiasis .
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Cat. No.: HY-N19184
CAS No.: 2900278-39-7
Target:  

Fungal

Cladobotric acid H is a polyketide antifungal agent found in the mycoparasitic fungus Hypomyces pseudocorticicola FKA-73. Cladobotric acid H inhibits growth of azole-sensitive and azole-resistant Candida auris, Aspergillus fumigatus, Aspergillus udagawae, Aspergillus felis, and Aspergillus lentulus. Cladobotric acid H can be used for the research of aspergillosis, candidiasis .
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Cat. No.: HY-N6777S
Penicillic acid- 13C8 is the 13C-labeled Penicillic acid (HY-N6777). Penicillic acid is a polyketide mycotoxin produced by several species of Aspergillus and Penicillium. Penicillic acid exhibits cytotoxicity in rat alveolar macrophages (AM) in vitro. Penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8 .
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Cat. No.: HY-170575
Target:  

Bacterial

Research Areas:  

Infection

Pks13-IN-1 (Compound 44) is an orally active inhibitor for Mycobacterium tuberculosis Polyketide synthase 13 (Pks13). Pks13-IN-1 inhibits M. tuberculosis strain H37Rv with a MIC of 0.07 μM. Pks13-IN-1 exhibits antibacterial efficacy in mouse model .
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Cat. No.: HY-N16429
CAS No.: 1442657-25-1
Neosartoricin D, a polyketide, is a microbial secondary metabolite. Neosartoricin D can be isolated from the cultural of Aspergillus nidulans. Neosartoricin D is an analog of Neosartoricin B (HY-N10311). Neosartoricin B is the secondary metabolite, which can be produced by Aspergillus nidulans. Neosartoricin B may regulate immunomodulatory effects with the host during infection and colonization by pathogenic fungi .
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Cat. No.: HY-N19229
CAS No.: 65718-85-6
Dihydrocitrinone is a polyketide secondary metabolite and the major urinary metabolite of citrinin, which can be isolated from Aspergillus strains derived from the rhizosphere soil of date palms. Dihydrocitrinone exerts independent toxic effects in renal cell cultures and zebrafish embryo models, enhances the toxic effects of Ochratoxin A through additive or synergistic actions, and increases the level of miR-731 in zebrafish embryos when acting in combination with Ochratoxin A .
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Cat. No.: HY-N20697
Ariestatin A is an antibacterial agent that exhibits significant inhibitory effects against a variety of Gram-positive bacteria, including Bacillus subtilis, Staphylococcus aureus, and methicillin-resistant Staphylococcus aureus. Ariestatin A is extracted from the fungus Austroacremonium gemini MST-FP2131, and it is a glycosylated hybrid polyketide with a saturated C15 alkyl side chain. Ariestatin A shows no cytotoxic activity against mammalian cells and does not affect the growth of Saccharomyces cerevisiae. Ariestatin A can be used for bacterial infections caused by the aforementioned Gram-positive bacteria .
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Cat. No.: HY-N21895
CAS No.: 96789-48-9
(Z)-Corallopyronin A is an isomer of Corallopyronin A (HY-N11622). Corallopyronin A is a polyketide natural product derived from myxobacteria and acts as a bacterial RNA polymerase (RNAP) inhibitor with antibacterial activity. Corallopyronin A binds to the switch region of RNA polymerase and allosterically blocks the transcription initiation process. Corallopyronin A exhibits in vitro antibacterial activity against Staphylococcus aureus, coagulase-negative staphylococci, Neisseria gonorrhoeae, and the filarial endosymbiont Wolbachia. (Z)-Corallopyronin A can be used for research related to bacterial infections .
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Cat. No.: HY-184460
CAS No.: 224427-79-6
Nafuredin A is a trinorsesquiterpene and polyketide derivative found in the mangrove sediment-derived fungi Talaromyces sp. SCSIO 41412 and Trichoderma harzianum D13. Nafuredin A regulates the ferroptosis pathway and upregulates ferroptosis-related genes. Nafuredin A alleviates hypoxia-reoxygenation-induced injury in oxygen-glucose deprivation/reperfusion cell models. Nafuredin A reduces pro-inflammatory cytokines and exerts hepatoprotective effects in animal models of hepatic ischemia-reperfusion injury. Nafuredin A inhibits the growth of phytopathogenic fungi Magnaporthe oryzae and Valsa mali. Nafuredin A can be used in studies related to hepatic ischemia-reperfusion injury and phytopathogenic fungal infections .
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Cat. No.: HY-N19119
CAS No.: 120461-93-0
Target:  

Fungal

Vertixanthone is an antifungal agent, with MIC values of 3.125 μg/mL against Candida albicans CMCC 98001 and 12.5 μg/mL against Aspergillus niger R330. Vertixanthone can be used for the research of candida albicans infection, aspergillus niger infection .
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Cat. No.: HY-148869
CAS No.: 5060-32-2
Synonyms: R-Hexanoyl-CoA; R-Hexanoyl coenzyme A
Hexanoyl coenzyme A is a short-chain fatty acyl-CoA thioester. Hexanoyl coenzyme A competes with butyryl-CoA to abolish the dehydrogenation effect of medium-chain acyl-CoA dehydrogenase on butyryl-CoA, and does not serve as a substrate for short-chain acyl-CoA dehydrogenase. Hexanoyl coenzyme A acts as a biosynthetic precursor for the synthesis of olivetolic acid and cannabinoids. Hexanoyl coenzyme A is applicable to research related to short-chain acyl-CoA dehydrogenase deficiency .
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Cat. No.: HY-N19885
CAS No.: 159933-97-8
Palmarumycin C12 is a fungal metabolite that can be isolated from cultures of Sphaeropsidaes sp. F-24'707. Palmarumycin C12 exhibits antifungal activity. Palmarumycin C12 can be used for the research of fungal infections .
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Cat. No.: HY-N19641
CAS No.: 244182-09-0
Synonyms: Dichlorodiaportin
Dichlorodiaporthin (Dichlorodiaportin) is an isocoumarin metabolite found in cultures of Penicillium nalgiovense. Dichlorodiaporthin acts as an antibacterial agent against various bacterial species .
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Cat. No.: HY-N19907
CAS No.: 1374428-43-9
Phomopsinone A is an Antifungal agent. Phomopsinone A is isolated from Phomopsis sp. Phomopsinone A exhibits activity against plant and crop pathogens Pyricularia oryzae, Septoria tritici and Botrytis cinerea. Phomopsinone A can be used in the research of plant/crop fungal diseases .
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