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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1149 Results for "
Neuronal
" in MedChemExpress (MCE) Product Catalog:
Products (1149)
1149 Results for "Neuronal" in MCE Product Catalog:
Cat. No.: HY-184087
CAS No.: 205807-59-6
Synonyms: TNF484
Target:
Research Areas:
PKF 242-484 (TNF484) is an orally active dual inhibitor of TACE/MMPs, with Ki values of 3.6, 0.1, 0.9, 1, and 4.5 nM against hMMP-1, hMMP-2, hMMP-3, hMMP-9, and hMMP-13, respectively. PKF 242-484 inhibits the enzymatic activities of MMPs and ADAM17, reduces the release of TNF-α, suppresses the proliferation, migration and invasion of cancer cells, and regulates inflammatory cell infiltration and cytokine production. PKF 242-484 can be used in studies related to airway inflammatory diseases such as asthma and chronic obstructive pulmonary disease, intestinal ischemia-reperfusion injury, epilepsy-induced neuronal damage, and hepatocellular carcinoma .
Cat. No.: HY-B0640AR
CAS No.: 108929-04-0
Synonyms: WAL801 hydrochloride (Standard)
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Epinastine (hydrochloride) (Standard) is the analytical standard of Epinastine hydrochloride (HY-B0640A). This product is intended for research and analytical applications. Epinastine hydrochloride (WAL801 hydrochloride) is a selective and orally active histamine H1 receptor antagonist, CD96/PVR inhibitor and mast cell stabilizer. Epinastine hydrochloride has high affinity for neuronal octopamine receptors in locusts (Ki = 2 nM) and honeybees (Ki = 1.1 nM). Epinastine hydrochloride inhibits TARC, IL-8, and IL-4. Epinastine hydrochloride activates anti-colon cancer immunity and inhibits Substance P (HY-P0201)-induced scratching behavior and increased vascular permeability. Epinastine hydrochloride can be used in the research of allergic diseases .
Cat. No.: HY-B0653AS
Synonyms: (S)-(–)-Bupivacaie-d9hydrochloride
Cat. No.: HY-B1692R
CAS No.: 15985-39-4
Synonyms: MSX (Standard); MSO (Standard)
Target:
Research Areas:
L-Methionine-DL-sulfoximine (Standard) is the analytical standard of L-Methionine-DL-sulfoximine (HY-B1692). This product is intended for research and analytical applications. L-Methionine-DL-sulfoximine (MSX; MSO), a highly specific and irreversible inhibitor of Glutamine synthetase (GS), is also a potent convulsant which metabolically and morphologically primarily affects astroglia. L-Methionine-DL-sulfoximine has been employed to inhibit the Gln-dependent ammonia-stimulated neuronal toxicity in vitro, potentiating Gln deficit-dependent depression. L-Methionine-DL-sulfoximine tremendously increases the rate of release of fixed nitrogen in cyanobacteria. L-Methionine-DL-sulfoximine is a promising candidate for research in biofertilizers and convulsive seizures (CS) .
Cat. No.: HY-N6043
CAS No.: 69039-02-7
Cat. No.: HY-NP0204
Synonyms: Mouse Serum Albumin
Cat. No.: HY-P2612
CAS No.: 199999-60-5
Target:
Research Areas:
Target:
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Cat. No.: HY-P4184A
Synonyms: (Ser4,Ile8)-Oxytocin acetate
Target:
Research Areas:
Cat. No.: HY-U00050S
Synonyms: E-10-OH-NT-d3
Research Areas:
(E)-10-Hydroxynortriptyline-d3 (E-10-OH-NT-d3) is the deuterated-labeled (E)-10-Hydroxynortriptyline (HY-U00050). (E)-10-Hydroxynortriptyline (E-10-OH-NT) is a blood-brain barrier-permeable norepinephrine uptake inhibitor. (E)-10-Hydroxynortriptyline effectively promotes central norepinephrine neuronal transmission, with little interindividual variation in in vivo potency. (E)-10-Hydroxynortriptyline has low affinity for muscarinic receptors, exhibits only extremely weak anticholinergic activity, and does not inhibit salivary secretion. (E)-10-Hydroxynortriptyline can be used in studies related to depression .
Cat. No.: HY-W027553
CAS No.: 62732-44-9
Synonyms: NIK-247 free base; Amiridine free base
Research Areas:
Ipidacrine is orally active and brain-penetrant AChE and BuChE inhibitors with IC50 values of 1 μM and 1.9 μM, respectively, which is also a partial agonist of M2-cholinergic receptors and a reversible cholinesterase inhibitor. Ipidacrine has a stimulating effect on neuromuscular transmission and excitation along the nerve fibres with a moderately anti-pain effect. Ipidacrine is an aminopyridines and is structurally similar to Tacrine (HY-111338). Ipidacrine is effective in various amnesia models, improves erectile function and inhibits K + and Na +-channels in the neuronal membrane in diabetic rats. Ipidacrine is promising for research of Alzheimer’s disease, ischaemic stroke, idiopathic neuropathy of the facial nerve, diabetes mellitus-induced erectile dysfunction and other deficits in central or peripheral cholinergic deseases .
Cat. No.: HY-W040045R
CAS No.: 18466-51-8
Synonyms: Pelargonidin-3-O-glucoside chloride (Standard)
Cat. No.: HY-151071
CAS No.: 2488761-18-6
Research Areas:
TMX-3013 is a CDK inhibitor capable of inhibiting the activity of CDK1, CDK2, CDK4, CDK5, and CDK6, with IC50 values of 0.9 nM, <0.5 nM, 24.5 nM, 0.5 nM, and 15.6 nM, respectively. TMX-3013 can be used as a target protein ligand, conjugated with the PROTAC linker and the CRBN ligand Thalidomide (HY-14658) for the synthesis of PROTAC TMX-2138 (HY-164906). TMX-3013 can also act as an effector ligand, binding to target proteins HaloTag or FKBP, and can be used in the synthesis of regulated induced proximity targeting chimeras (RIPTACs) .
Cat. No.: HY-163280
CAS No.: 3011930-28-9
Target:
Research Areas:
JGB-1-155 is a nicotinamide phosphoribosyltransferase (NAMPT) activator and also a reactive oxygen species (ROS) inhibitor. JGB-1-155 binds to NAMPT, thereby enhancing its catalytic activity and increasing intracellular NAD + levels. JGB-1-155 alleviates the elevation of ROS levels induced by various types of damage. JGB-1-155 can be used in research related to neurodegenerative diseases .
Cat. No.: HY-179037
CAS No.: 1120333-38-1
Research Areas:
NecroX-2 is a potent inhibitor of caspase-independent necrosis. NecroX-2 exhibits antioxidant activity by scavenging DPPH radicals and peroxynitrite. NecroX-2 inhibits t-BHP-induced mitochondrial ROS/RNS generation, and protects t-BHP and Doxorubicin (HY-15142A)-induced cell death in vitro. NecroX-2 can be used for research on neurological diseases .
Cat. No.: HY-N21686
CAS No.: 1927024-57-4
Target:
Cat. No.: HY-P77092
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: STXBP1; NSec1; Syntaxin Binding Protein 1; Unc-18A; Syntaxin-Binding Protein 1; Unc18-1; MUNC18-1; HUNC18; Protein Unc-18 Homolog 1; P67; Protein Unc-18 Homolog A; Neuronal SEC1; RbSec1; UNC18A; N-Sec1; DEE4; UNC18
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P705527
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HOMER1; Homer, Neuronal Immediate Early Gene, 1; Homer Scaffold Protein 1; Homer Homolog 1 (Drosophila); SYN47; Homer Homolog 1; Homer Protein Homolog 1; HOMER1A; Ves-1; HOMER1B; Homer Scaffolding Protein 1; HOMER1C; HOMER-1B; HOMER1F; Homer-1; HOMER
Species:
Human
Source:
E. coli
Cat. No.: HY-L001
27,212 compounds
Bioactive compounds are a general term for a class of substances that can cause certain biological effects in the body, which are the main source of small molecule drugs. These compounds generally penetrate cell membranes, act on specific target proteins in cells, regulate intracellular signaling pathways, and cause some changes in cell phenotype.
MCE owns a unique collection of 27,212 compounds with confirmed biological activities and clear targets. These compounds include natural products, innovative compounds, approved compounds, and clinical compounds. These can also be used for signal pathway research, drug discovery and drug repurposing, etc.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
