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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
139 Results for "
Ca2 release
" in MedChemExpress (MCE) Product Catalog:
Products (139)
139 Results for "Ca2 release" in MCE Product Catalog:
Cat. No.: HY-116484
CAS No.: 129041-16-3
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Way 100252 is a presynaptic GABA autoreceptor agonist. Way 100252 exerts its effect by inhibiting GABA release, and it suppresses GABA release induced by K +, Ca 2+, Ouabain (HY-B1457) and electrical stimulation, with a more potent inhibitory effect on electrically evoked release. Way 100252 is used for studies related to GABAergic neurotransmission .
Cat. No.: HY-121253
CAS No.: 854091-96-6
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NAADP receptor modulator-1 is a cell-permeable NAADP receptor modulator. NAADP receptor modulator-1 competes with NAADP for binding sites and inhibits NAADP-induced Ca 2+ release .
Cat. No.: HY-100168BR
CAS No.: 73630-08-7
Cat. No.: HY-183206
CAS No.: 149455-36-7
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UR 8225 is an orally active ATP-sensitive K + channel activator with vasodilator, smooth muscle relaxant, antihypertensive, and bronchodilator activities. UR 8225 induces membrane hyperpolarization by increasing outward K + conductance and reduces Ca 2+ influx through voltage-gated L-type Ca 2+ channels. UR 8225 reduces total peripheral vascular resistance, shortens cardiac action potential duration, inhibits agonist-induced Ca 2+ influx, and stimulates renin release. UR 8225 induces reflex tachycardia but lacks β-adrenergic receptor blocking activity. UR 8225 is widely applicable to research in fields related to hypertension, myocardial ischemia, ventricular fibrillation, and other conditions .
Cat. No.: HY-183549
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Ferroptosis/apoptosis inducer-4 is a pyridine-hydrazone-derived Cu (II) complex and a synergistic inducer of ferroptosis and apoptosis. Ferroptosis/apoptosis inducer-4 exerts anti-tumor proliferation and anti-metastasis effects with extremely low systemic toxicity. Ferroptosis/apoptosis inducer-4 disrupts cellular redox homeostasis by depleting glutathione and generating hydroxyl radicals through the Cu 2+/Cu + redox cycle. Ferroptosis/apoptosis inducer-4 also triggers mitochondrial dysfunction and endoplasmic reticulum stress, which in turn lead to Ca 2+ release, mitochondrial Ca 2+ overload, and the formation of a ROS−Ca 2+ self-amplifying feedback loop. Ferroptosis/apoptosis inducer-4 can be used in studies related to cervical cancer .
Cat. No.: HY-166562S
Synonyms: Methotrimeprazine-d6 hydrochloride
Cat. No.: HY-N17738
CAS No.: 194737-13-8
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Terpenoids Plants Actaea simplex (DC.) Wormsk. ex Fisch. & C. A. Mey. Rhamnaceae Pentacyclic Triterpenoids
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Cat. No.: HY-180165
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Antiallergic agent-5 (Compound 4f) is an antiallergic agent. Antiallergic agent-5 suppresses Ca 2+ influx. Antiallergic agent-5 suppresses IgE/Ag-induced release of both IL-6 and TNF-α. Antiallergic agent-5 inhibits mast cell degranulation. Antiallergic agent-5 attenuates passive cutaneous anaphylaxis in mice and reduces vascular leakage .
Cat. No.: HY-15671A
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GKA50 quarterhydrate is a potent glucokinase activator (EC50=33 nM at 5 mM glucose) and stimulates insulin release from mouse islets of Langerhans. GKA50 quarterhydrate is a glucose-like activator of beta-cell metabolism in rodent and human islets and a Ca 2+-dependent modulator of insulin secretion. GKA50 quarterhydrate shows significant glucose lowering in high fat fed female rats .
Cat. No.: HY-125641A
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AL-34662 (formate) is a 5-HT2 receptor agonist (IC50: 0.8-1.5 nM). AL-34662 (formate) stimulates inositol phosphate turnover and Ca 2+ release in human ciliary muscle cells (h-CM) (E50: 289 nM) and human trabecular meshwork cells (h-TM) (E50: 254 nM). AL-34662 (formate) can be used in studies to lower intraocular pressure (IOP) .
Cat. No.: HY-135556
CAS No.: 83891-03-6
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Cat. No.: HY-189072
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Insecticidal agent 39 (compound I ai) is a potent insecticide that targets Ryanodine Receptor (RyR). The LC50 of Insecticidal agent 39 against M. separata is 0.26 mg/L. Insecticidal agent 39 specifically binds to and activates RyR, inducing the release of Ca 2+ from the sarcoplasmic reticulum into the cytoplasm, which leads to sustained muscle contraction and eventual paralysis and death of the pest. Insecticidal agent 39 can be used in studies related to lepidopteran pest infestation .
Cat. No.: HY-W011235
CAS No.: 57226-68-3
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Norfluoxetine hydrochloride is the active metabolite of the antidepressant Fluoxetine (HY-B0102); it is also a TREK-2 K2P potassium channel inhibitor. Norfluoxetine hydrochloride exhibits neuroimmunological activity, induces apoptosis in primary microglial cells, and inhibits the release of pro-inflammatory factors. Norfluoxetine hydrochloride inhibits high-threshold voltage-gated Ca 2+ currents in neurons with an EC50 of 20.4 μM. Norfluoxetine hydrochloride can be used in research related to depression, ischemic stroke, and epilepsy .
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MRGPRX1 agonist 1 is a highly potent MRGPRX1 agonist (EC50=50 nM) with greater than 50-fold selectivity for δ, μ, and κ opioid receptors. MRGPRX1 agonist 1 is inactive against MRGPRC11. MRGPRC11 inhibits high voltage-activated (HVA) Ca 2+ currents, reduces neurotransmitter release, and mitigates nociceptive transmission in the spinal cord. MRGPRX1 agonist 1 is useful for the study of chronic pain, especially neuropathic pain .
Cat. No.: HY-131040
CAS No.: 2068818-02-8
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NLRP3-IN-NBC6 is a potent, selective NLRP3 inflammasome inhibitor (IC50= 574 nM) that acts independently of Ca 2+. NLRP3-IN-NBC6 inhibits Nigericin (HY-127019)-induced inflammasome activation in THP-1 cells and Imiquimod (HY-B0180)-induced IL-1β release from LPS-primed bone marrow-derived macrophages (BMDMs) .
Cat. No.: HY-135556A
CAS No.: 107674-50-0
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Norfluoxetine oxalate is the active metabolite of the antidepressant Fluoxetine (HY-B0102); it is also a TREK-2 K2P potassium channel inhibitor. Norfluoxetine oxalate exhibits neuroimmunological activity, induces apoptosis in primary microglial cells, and inhibits the release of pro-inflammatory factors. Norfluoxetine oxalate inhibits high-threshold voltage-gated Ca 2+ currents in neurons with an EC50 of 20.4 μM. Norfluoxetine oxalate can be used in research related to depression, ischemic stroke, and epilepsy .
Cat. No.: HY-P11019
CAS No.: 3067986-23-3
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ROC-0929 (compound 13a) is a potent and selective inhibitor of secreted phospholipases A2 (sPLA2s) with an IC50 of 80 nM, specially targeting hGX. ROC-0929 inhibits the phosphorylation of ERK1/2 and p-38. Secreted phospholipases A2 (sPLA2s) are a family of disulfide-rich, Ca 2+-dependent enzymes that hydrolyze the sn-2 position of glycero-phospholipids to release a fatty acid and a lysophospholipid. ROC-0929 has the potential for researching inflammation related diseases .
Cat. No.: HY-N2522R
CAS No.: 33286-30-5
Synonyms: Gummiferin dipotassium (Standard)
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Cat. No.: HY-P2847
CAS No.: 330648-32-3
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
