NAADP receptor modulator-1 

NAADP receptor modulator-1 is a cell-permeable NAADP receptor modulator. NAADP receptor modulator-1 competes with NAADP for binding sites and inhibits NAADP-induced Ca²⁺ release^[1].

NAADP receptor modulator-1 (Compound 3) (0-30 μM) potently and selectively inhibits NAADP-induced Ca²⁺ release in egg homogenates of Lytechinus pictus sea urchins, with an IC₅₀ of 15 μM; it acts as a partial agonist at concentrations >100 μM^[1].
NAADP receptor modulator-1 shows weak competitive activity against [³²P]NAADP binding in Lytechinus pictus egg homogenates, with an IC₅₀ of 90 μM^[1].
NAADP receptor modulator-1 (10 mM) can cross the cell membrane of intact Lytechinus pictus sea urchin egg cells, and completely inhibits NAADP-induced Ca²⁺ release when administered extracellularly^[1].
When applied extracellularly, NAADP receptor modulator-1 (1 mM) potently attenuates CCK-induced Ca²⁺ oscillations in mouse pancreatic acinar cells, while exerting minimal effects on acetylcholine-induced Ca²⁺ responses^[1].
NAADP receptor modulator-1 (10 mM; extracellular incubation) completely abolishes NAADP-induced Ca²⁺ transients in intact sea urchin eggs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

308.08

C₈H₉IN₂O₃

854091-96-6

[I-].O=C(O)C1=CC=C[N+](=C1)CC(=O)N

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• [1]. Dowden J, et al. Cell-permeant small-molecule modulators of NAADP-mediated Ca2+ release. Chem Biol. 2006;13(6):659-665.  [Content Brief]