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Cat. No.: HY-116484

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Way 100252

Way 100252 is a presynaptic GABA autoreceptor agonist. Way 100252 exerts its effect by inhibiting GABA release, and it suppresses GABA release induced by K⁺, Ca²⁺, Ouabain (HY-B1457) and electrical stimulation, with a more potent inhibitory effect on electrically evoked release. Way 100252 is used for studies related to GABAergic neurotransmission.

For research use only. We do not sell to patients.

CAS No.: 129041-16-3
Formula: C₂₆H₂₅NO₂
Molecular Weight:383.48

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Please store the product under the recommended conditions in the Certificate of Analysis.

Way 100252 Chemical Structure

CAS No.: 129041-16-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
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Biological Activity

Description

In Vitro

Way 100252 dose-dependently inhibits the release of [³H] GABA evoked by various stimuli in cross-cut rat cerebral cortical slices, with pD₂ values of 5.8 (Ca²⁺), 7.4 (K⁺), 6.3 (electrical stimulation) and 6.0 (Ouabain (HY-B1457)) for different stimuli, respectively, and the maximum inhibitory effect ranges from 40% to 90%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 129041-16-3
Molecular Weight 383.48
Formula C₂₆H₂₅NO₂
SMILES

O=C(CCCN(CC1=C2C=CC=CC2=CC=C1)CC3=C4C=CC=CC4=CC=C3)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Ca²⁺ Staining Technique
Ca²⁺ staining is an experimental technique that utilizes specific fluorescent probes (such as Fluo-4 AM, Fura-2, etc.) to qualitatively or quantitatively detect dynamic changes in intracellular Ca²⁺ concentrations; this is achieved by monitoring the changes in fluorescent signals generated when these probes bind to free intracellular calcium ions. The underlying principle relies primarily on the presence of chelating groups within the probe's molecular structure that possess high affinity for calcium ions.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Dunlop J, et al. WAY 100252 inhibits evoked [3H]GABA release when tested against a number of release-inducing stimuli. Biochem Soc Trans. 1993 May;21(2):112S.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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