1 Result for "

(2S)-2'-Methoxykurarinone

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "(2S)-2'-Methoxykurarinone" in MCE Product Catalog:

(2S)-2'-Methoxykurarinone
(2S)-2'-Methoxykurarinone
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Cat. No.: HY-N1746
CAS No.: 270249-38-2
Synonyms: 2'-O-Methylkurarinone
Category:  

Metabolic Disease Leguminosae Extract Plants Sophora flavescens Aiton Flavonoids Flavonones Phenols Polyphenols Disease Research Fields Inflammation/Immunology

Target:  

RANKL/RANK Parasite NF-κB Heme Oxygenase (HO) Akt JNK p38 MAPK Reactive Oxygen Species (ROS)

(2S)-2'-Methoxykurarinone (2'-O-Methylkurarinone) is a flavanone natural product found in the roots of Sophora flavescens, possessing anti-sepsis, inhibitory effects on osteoclast differentiation and bone resorption, anti-inflammatory, and anti-Plasmodium activities. (2S)-2'-Methoxykurarinone exhibits an EC50 = 2.4 μM against the FCR-3 strain of Plasmodium falciparum. In sepsis models, (2S)-2'-Methoxykurarinone modulates immune cell function and inhibits inflammation and oxidative stress. In bone-related models, (2S)-2'-Methoxykurarinone blocks osteoclast differentiation and bone resorption, and inhibits RANKL-mediated Akt, p38, and JNK signaling pathways. In skin inflammation models, (2S)-2'-Methoxykurarinone inhibits NF-κB pathway activation, upregulates HO-1 expression, and suppresses CCL27 chemokine production in HaCaT cells. (2S)-2'-Methoxykurarinone is useful for research on osteoporosis, sepsis, inflammatory skin diseases (such as atopic dermatitis and allergic contact dermatitis), and malaria .
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