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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
26 Results for "
(S,R,S)-AHPC-PEG2-C4-Cl
" in MedChemExpress (MCE) Product Catalog:
Products (26)
26 Results for "(S,R,S)-AHPC-PEG2-C4-Cl" in MCE Product Catalog:
1
1 Cited Publications
Synonyms: VH032-PEG2-C4-Cl; VHL Ligand-Linker Conjugates 7; E3 ligase Ligand-Linker Conjugates 10
Research Areas:
(S,R,S)-AHPC-PEG2-C4-Cl (VH032-PEG2-C4-Cl) is a conjugate of ligands for E3 and 13-atom-length linker. The connector of linker is Halogen group. (S,R,S)-AHPC-PEG2-C4-Cl incorporates the (S,R,S)-AHPC based VHL ligand and an alkyl/ether-based linker. (S,R,S)-AHPC-PEG2-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays .
1
1 Cited Publications
Synonyms: VH032-PEG2-N3; VHL Ligand-Linker Conjugates 6; E3 ligase Ligand-Linker Conjugates 13
Research Areas:
(S,R,S)-AHPC-PEG2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-PEG2-N3 can be used for the synthesis of PROTACs .
Synonyms: VH032-PEG2-NH2 hydrochloride; VHL Ligand-Linker Conjugates 3 hydrochloride; E3 ligase Ligand-Linker Conjugates 6
Research Areas:
(S,R,S)-AHPC-PEG2-NH2 hydrochloride (VH032-PEG2-NH2 hydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs .
Target:
Research Areas:
(S,R,S)-AHPC-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
Synonyms: VH032-PEG2-NH2 ; VHL Ligand-Linker Conjugates 3 ; E3 ligase Ligand-Linker Conjugates 6 Free Base
Research Areas:
(S,R,S)-AHPC-PEG2-NH2 (VH032-PEG2-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs .
Synonyms: VHL Ligand-Linker Conjugates 11; E3 ligase Ligand-Linker Conjugates 11
Research Areas:
(S,R,S)-AHPC-(C3-PEG)2-C6-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-(C3-PEG)2-C6-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays .
Synonyms: (S,R,S)-AHPC-Me-PEG2-dabrafenib
Target:
Research Areas:
DD-03-156 ((S,R,S)-AHPC-Me-PEG2-dabrafenib) is a VHL-based PROTAC degrader targeting CDK17 and LIMK2. DD-03-156 serves as an excellent lead-like starting point for the development of selective chemical probes targeting CDK17 degradation .
Cat. No.: HY-103603B
CAS No.: 2341796-76-5
Synonyms: VH032-PEG2-NH2 dihydrochloride
Research Areas:
(S,R,S)-AHPC-PEG2-NH2 dihydrochloride (VH032-PEG2-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs .
Cat. No.: HY-168019
CAS No.: 2923734-95-4
Research Areas:
(S,R,S)-AHPC-PEG2-C2-boc is an E3 Ligase Ligand-Linker Conjugate. (S,R,S)-AHPC-PEG2-C2-boc can be used to synthesize PROTAC YAP degrader-1 (HY-168016) .
Cat. No.: HY-W800669
CAS No.: 2757045-58-0
Target:
Research Areas:
(S, R, S)-AHPC-PEG2-NHS ester is a synthetic PROTAC linker that incorporatess an E3 ligase ligand with a PEG linker to empower PROTAC medicine chemistry. NHS ester is reactive with amine moiety. The hydrophilic PEG spacer increases its aqueous solubility.
Cat. No.: HY-168643
CAS No.: 3033933-58-0
Research Areas:
Me-(S,R,S)-AHPC-PEG2-OTs is a conjugate of E3 ligase ligand and linker (E3 Ligase Ligand-Linker Conjugates) used in the synthesis of PROTAC HIF-1α degrader-1 (HY-168641) .
Cat. No.: HY-176422
CAS No.: 2138439-54-8
Research Areas:
(S,R,S)-AHPC-Amide-PEG2-C2-NH2 is an E3 Ligase Ligand-Linker Conjugates that can be used to synthesize PROTAC PI3K/110β degrader-1 (HY-176421) .
Cat. No.: HY-185724
Target:
Research Areas:
rG4 mut_AHPC_PEG2 is a structure-disruptive negative control PROTAC. rG4 mut_AHPC_PEG2 demonstrates that the RNA G-quadruplex conformation is an absolute prerequisite for the recruitment and degradation of DHX36 by retaining the E3-recruiting moiety (AHPC-PEG2) while disrupting the secondary structure of the nucleic acid moiety (mutated RNA G-quadruplex), .
Cat. No.: HY-W1130395
Research Areas:
(S,R,S)-AHPC-PEG2-SH is a VHL ligand based on (S,R,S)-AHPC that recruits von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-PEG2-SH can be linked to a target protein ligand via a linker to form a PROTACs.
Cat. No.: HY-W800760
CAS No.: 2839806-94-7
Research Areas:
(S, R, S)-AHPC-PEG6-Tos is a combination of a von Hippel-Lindau (VHL)-recruiting ligand and PEGylated crosslinker with a tosyl group. The tosyl group is a good leaving group for nucleophilic substitution reactions. (S, R, S)-AHPC-PEG2-Tos is useful for synthesis of PROTAC compounds and molecules for targeted protein degradation.
Cat. No.: HY-403301
CAS No.: 2250056-22-3
Research Areas:
(S,R,S)-AHPC-Me-amide-C-O-PEG2-COOH is an E3 ligase ligand-linker conjugate. (S,R,S)-AHPC-Me-amide-C-O-PEG2-COOH can be used for synthesis of PROTACs .
Cat. No.: HY-185723
Target:
Research Areas:
rG4 WT_AHPC_PEG2 is a selective RNA G-quadruplex-based DHX36 PROTAC degrader with a Kd value of 79.7 nM. rG4 WT_AHPC_PEG2 degrades DHX36 via a proteasome-dependent mechanism, without significantly degrading other G4-binding proteins including NCL, DHX9, hnRNP, SRSF and FMR1 .
Cat. No.: HY-103603R
CAS No.: 2097973-72-1
Synonyms: VH032-PEG2-NH2 hydrochloride (Standard); VHL Ligand-Linker Conjugates 3 hydrochloride (Standard); E3 ligase Ligand-Linker Conjugates 6 (Standard)
Research Areas:
(S,R,S)-AHPC-PEG2-NH2 hydrochloride (Standard) is the analytical standard of (S,R,S)-AHPC-PEG2-NH2 hydrochloride (HY-103603). This product is intended for research and analytical applications. (S,R,S)-AHPC-PEG2-NH2 hydrochloride (VH032-PEG2-NH2 hydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs .
Cat. No.: HY-103599R
CAS No.: 2010159-45-0
Synonyms: VH032-PEG2-N3 (Standard); VHL Ligand-Linker Conjugates 6 (Standard); E3 ligase Ligand-Linker Conjugates 13 (Standard)
Research Areas:
(S,R,S)-AHPC-PEG2-N3 (Standard) is the analytical standard of (S,R,S)-AHPC-PEG2-N3 (HY-103599). This product is intended for research and analytical applications. (S,R,S)-AHPC-PEG2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-PEG2-N3 can be used for the synthesis of PROTACs .
Cat. No.: HY-103603AR
CAS No.: 2010159-60-9
Synonyms: VH032-PEG2-NH2 (Standard); VHL Ligand-Linker Conjugates 3 (Standard); E3 ligase Ligand-Linker Conjugates 6 Free Base (Standard)
Research Areas:
(S,R,S)-AHPC-PEG2-NH2 (Standard) is the analytical standard of (S,R,S)-AHPC-PEG2-NH2 (HY-103603A). This product is intended for research and analytical applications. (S,R,S)-AHPC-PEG2-NH2 (VH032-PEG2-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
