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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
β-Amyloid (1-42), human
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "β-Amyloid (1-42), human" in MCE Product Catalog:
27
27 Publications Verification
Cat. No.: HY-P1363A
CAS No.: 107761-42-2
Synonyms: Amyloid β-peptide (1-42) (human)
Target:
Research Areas:
β-Amyloid (1-42) (Amyloid β-peptide (1-42)), human, a 42-amino acid peptide that has not been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4 °C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37 °C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .
27
27 Publications Verification
Cat. No.: HY-P1363B
CAS No.: 107761-42-2
Target:
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β-Amyloid (1-42), human, HFIP-treated, a 42-amino acid peptide that has been treated with HFIP from β-Amyloid (1-42), human (HY-P1363A), is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human, HFIP-treated remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human, HFIP-treated, after being dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4°C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37°C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .
27
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β-Amyloid (1-42) (Amyloid β-peptide (1-42), human TFA, a 42-amino acid peptide that has not been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human TFA remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human TFA, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4 °C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37 °C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .
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1
1 Cited Publications
Cat. No.: HY-P1362
CAS No.: 317366-82-8
Synonyms: Amyloid β Peptide (42-1)(human)
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Cat. No.: HY-P1363F1
Synonyms: Biotin-Amyloid β-peptide (1-42) (human) TFA
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Cat. No.: HY-P1363S
Synonyms: Amyloid β-peptide-15N (1-42) (human) TFA
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Cat. No.: HY-P4867A
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Cat. No.: HY-P1362F
Synonyms: Cy5-Amyloid β Peptide (42-1)(human) Tris
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Cat. No.: HY-P5905
Synonyms: Citrullinated Aβ (1-42); Citrullinated Aβ42
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Cat. No.: HY-P1378A
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Cat. No.: HY-P1363S1
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Cat. No.: HY-P4867
CAS No.: 1678415-52-5
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Cat. No.: HY-P1378
CAS No.: 134500-80-4
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Cat. No.: HY-P1363D
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Cat. No.: HY-P4882
CAS No.: 183449-57-2
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Cat. No.: HY-P1362A
Synonyms: Amyloid β Peptide (42-1)(human) TFA
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Cat. No.: HY-P4861
CAS No.: 1872440-40-8
Cat. No.: HY-P1362FA
Synonyms: Cy5-Amyloid β Peptide (42-1)(human) (TFA
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Cat. No.: HY-P706264
Purity: ≥ 95%, as determined by HPLC.
Synonyms: ¹⁵N-Aβ(1-42); ¹⁵N-Beta-Amyloid(1-42); ¹⁵N-Aβ(1-42); ¹⁵N-Amyloid β Protein Fragment1-42; ¹⁵N-Amyloid β-Peptide(1-42); ¹⁵N-β-Amyloid 42; ¹⁵N-β-Amyloid(1-42); APP; PreA4; Prev. AD1; CVAP; Alzheimer Disease Amyloid A4 Protein Homolog; Beta-Amyloid Precursor Protein; Amyloid-Beta Precursor Protein; Testicular Tissue Protein Li 2; Amyloid Precursor Protein; Beta-Amyloid Peptide(1-40); Alpha-SAPP; Beta-Amyloid Peptide(1-42); ABPP; Alternative Protein APP; Amyloid Beta (A4) Precursor Protein; Beta-Amyloid Peptide; Amyloid-Beta (A4) Precursor Protein; Amyloid Beta Protein; Alzheimer Disease Amyloid Protein; Alzheimer Disease; Cerebral Vascular Amyloid Peptide; CTFgamma; Amyloid Beta A4 Protein; ABETA; Amyloid-Beta A4 Protein; AAA; Peptidase Nexin-II; PN2; Protease Nexin-II; A4; PN-II; Amyloid Beta Precursor Protein; APPI
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
