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2 Results for "
2,4-Dinitrobenzenesulfonic acid
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "2,4-Dinitrobenzenesulfonic acid" in MCE Product Catalog:
Cat. No.: HY-W095633
CAS No.: 89-02-1
2,4-Dinitrobenzenesulfonic acid (Compound 3) is a ecto-5'-Nucleotidase (CD73) inhibitor with a Ki value of 63 μM for human and 144 μM for rat. 2,4-Dinitrobenzenesulfonic acid can inhibit the hydrolysis of adenosine monophosphate (AMP) to generate adenosine. 2,4-Dinitrobenzenesulfonic acid can be used for the research of cancer .
Cat. No.: HY-W324435
CAS No.: 885-62-1
Synonyms: Sodium 2,4-dinitrobenzenesulfonate; DNBS sodium salt; DNBSO sodium salt
Research Areas:
2,4-Dinitrobenzenesulfonic acid (DNBS; DNBSO) sodium salt (Sodium 2,4-dinitrobenzenesulfonate) is a classic colitis inducer that relies on activation of the NF-κB p65/COX-2/p38 pathway. As a hapten, 2,4-Dinitrobenzenesulfonic acid sodium salt stimulates the production of immune responses in colonic tissues, triggers oxidative stress and inflammatory reactions, and thereby leads to colonic injury. 2,4-Dinitrobenzenesulfonic acid sodium salt successfully induces models of colitis and ulcerative colitis in rats, causing pathological changes such as ulcers, edema, stenosis, shortening and organ adhesion in the distal colon, along with significant increases in the levels of inflammatory indicators and endoplasmic reticulum stress marker proteins. 2,4-Dinitrobenzenesulfonic acid sodium salt is widely used in studies on the mechanisms related to colitis and ulcerative colitis .
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Protocols
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