3 Results for "

2-Propylpent-4-ynoic acid

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "2-Propylpent-4-ynoic acid" in MCE Product Catalog:

Cat. No.: HY-W787758
CAS No.: 24102-11-2
Synonyms: 4-yn-VPA
Target:  

HDAC P-glycoprotein

Research Areas:  

Neurological Disease Cancer

2-Propylpent-4-ynoic acid (4-yn-VPA) is a HDAC inhibitor (with an IC50 of 0.5 mM against human HDAC). 2-Propylpent-4-ynoic acid also induces P-glycoprotein function, and exhibits teratogenicity, fetal growth inhibition and neurotoxicity. 2-Propylpent-4-ynoic acid shows significant stereospecific teratogenic effects, with the S-enantiomer being more teratogenic than the R-enantiomer and other analogs. The neurotoxicity of 2-Propylpent-4-ynoic acid is independent of its stereochemical structure. 2-Propylpent-4-ynoic acid has been used in studies related to the pathogenesis of colon cancer and neural tube defects such as exencephaly .
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