Search Result

Results for "

4-trifluoromethyl

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Amino Acid Derivatives (4) Antibiotic (1) Apoptosis (1) Bacterial (4) Biochemical Assay Reagents (4) Calcium Channel (1) Cathepsin (1) CD38 (1) Cholecystokinin Receptor (1) COX (2) CRFR (2) Cytochrome P450 (3) Drug Derivative (2) Drug Intermediate (1) Drug Metabolite (2) DYRK (1) Endogenous Metabolite (2) Endothelin Receptor (1) Ferroportin (1) Fluorescent Dye (3) Interleukin Related (1) Isotope-Labeled Compounds (9) MMP (3) MOFs (5) NF-κB (1) Nucleoside Antimetabolite/Analog (2) Parasite (2) Prostaglandin Receptor (1) PROTAC Linkers (1) Protease Activated Receptor (PAR) (2) Reactive Oxygen Species (ROS) (1) Reference Standards (4) TNF Receptor (2) Vasopressin Receptor (1) Virus Protease (1)
By Research Areas:	Cancer (8) Cardiovascular Disease (2) Infection (7) Inflammation/Immunology (6) Metabolic Disease (4) Neurological Disease (2)
Oligonucleotides:	Adenosine (2) Nucleoside Analogs (2)

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-134124

*Glutathione ethyl* ester**	Reactive Oxygen Species (ROS)	Metabolic Disease
Glutathione ethyl ester is a cell-permeable GSH donor and provides an efficient supply of GSH to the oocyte. Glutathione ethyl ester shows positive effect on the in vitro production of embryos by enhancement of the antioxidative defense .

HY-P10272

Rusfertide PTG-300	Ferroportin	Others
Rusfertide is a peptide mimetic of natural hepcidin, which targets and degrades ferroportin, reduces serum iron and transferrin-saturation, and thus regulates the production of red blood cells. Rusfertide ameliorates the polycythemia vera, β-thalassemia and hereditary hemochromatosis .

HY-A0248A

Polymyxin B1 1 Publications Verification	Bacterial	Infection
Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-D0981

*7-Amino-4-(trifluoromethyl)coumarin* 1 Publications Verification Coumarin 151; AFC	Fluorescent Dye	Others
7-Amino-4-(trifluoromethyl)coumarin (Coumarin 151) is a fluorescent marker for the sensitive detection of proteinases. The excitation and emission wavelengths are 400 and 490 nm, respectively.

HY-W013962

4-(Trifluoromethyl)-L-phenylalanine 1 Publications Verification	Amino Acid Derivatives	Others
4-(Trifluoromethyl)-L-phenylalanine is a phenylalanine derivative .

HY-34781

4'-Trifluoromethyl-2-biphenyl carboxylic acid	Drug Derivative	Cardiovascular Disease Metabolic Disease
4'-Trifluoromethyl-2-biphenyl carboxylic acid is an orally active hypolipidemic agent .

HY-P1108A

Astressin 2B TFA 1 Publications Verification	CRFR	Neurological Disease Inflammation/Immunology
Astressin 2B TFA is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist (rCRFR2, IC₅₀=0.57 nM). Astressin 2B TFA blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin (HY-14397)-induced hemorrhagic intestinal injury in rats. Astressin 2B TFA reverses the protective effects of Urocortin 1 against intestinal hypermotility, bacterial invasion and upregulation of inflammatory mediators. Astressin 2B TFA also blocks the anxiogenic effect of Urocortin 2 and attenuates stress-induced anxiety-related behaviors. In the Clostridioides difficile toxin A (C. difficile toxin A)-mediated enteritis model, Astressin 2B TFA mimics the phenotype of CRFR2-deficient mice, significantly exacerbating intestinal epithelial damage, edema, neutrophil migration and the expression of multiple proinflammatory cytokines. Astressin 2B TFA is an important tool molecule for investigating the intestinal protective mechanisms of CRFR2 ^[4] .

HY-P1108

Astressin 2B 1 Publications Verification	CRFR	Neurological Disease Inflammation/Immunology
Astressin 2B is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist (rCRFR2, IC₅₀=0.57 nM). Astressin 2B blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin (HY-14397)-induced hemorrhagic intestinal injury in rats. Astressin 2B reverses the protective effects of Urocortin 1 against intestinal hypermotility, bacterial invasion and upregulation of inflammatory mediators. Astressin 2B also blocks the anxiogenic effect of Urocortin 2 and attenuates stress-induced anxiety-related behaviors. In the Clostridioides difficile toxin A (C. difficile toxin A)-mediated enteritis model, Astressin 2B mimics the phenotype of CRFR2-deficient mice, significantly exacerbating intestinal epithelial damage, edema, neutrophil migration and the expression of multiple proinflammatory cytokines. Astressin 2B is an important tool molecule for investigating the intestinal protective mechanisms of CRFR2 ^[4] .

HY-D0149

4-(Trifluoromethyl)umbelliferone	Cytochrome P450	Others
4-(Trifluoromethyl)umbelliferone is fluorescent probe substrate for rat hepatic cytochrome P450 enzymes .

HY-W002441

*2-Bromo-4-(trifluoromethyl)pyridine*	Biochemical Assay Reagents	Others
2-Bromo-4-(trifluoromethyl)pyridine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W027773

*7-Methoxy-4-(trifluoromethyl)coumarin* MFC	Cytochrome P450 Fluorescent Dye	Others
7-Methoxy-4-(trifluoromethyl)coumarin (MFC) is a fluorescent substrate for cytochrome P450 and can quantify CYP activity .

HY-112731

TFAP N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide	COX Endogenous Metabolite	Metabolic Disease
TFAP is a selective cyclooxygenase-1 (COX-1) inhibitor, with an IC₅₀ of 0.8 μM.

HY-66035

4-(Trifluoromethyl)nicotinic acid 4-(trifluoromethyl)pyridine-3-carboxylic acid	Parasite	Infection
4-(Trifluoromethyl)nicotinic acid (4-(Trifluoromethyl)pyridine-3-carboxylic acid) is a metabolite of the pyridinecarboxamide insecticide Flonicamid (HY-119649) .

HY-W004212

4-(Trifluoromethyl)-1H-pyrazole	Biochemical Assay Reagents	Others
4-(Trifluoromethyl)-1H-pyrazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W267897

*7-Benzyloxy-4-(trifluoromethyl)coumarin* 7-BFC	Cytochrome P450	Others
7-Benzyloxy-4-(trifluoromethyl)coumarin (7-BFC) is a coumarin fluorescent substrate. 7-Benzyloxy-4-(trifluoromethyl)coumarin is a substrate for cDNA-expressed CYP1A2 and CYP3A4 and is metabolized to 7-hydroxy-4-trifluoromethylcoumarin (HFC). 7-Benzyloxy-4-(trifluoromethyl)coumarin is used for rapid CYP isoform metabolism and inhibition screening studies .

HY-103033

T.cruzi-IN-1	Parasite	Infection
T.cruzi-IN-1 is a potent *Trypanosoma cruzi* inhibitor with an IC₅₀ of 8 nM. T.cruzi-IN-1, a 4-trifluoromethyl substituted analog, has the potential for both the acute and chronic stages of Chagas disease .

HY-P10143

MMP-2/MMP-9 Substrate Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt	MMP	Others
MMP-2/MMP-9 Substrate (Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt) is a synthetic chromogenic polypeptide substrate whose core structure mimics the cleavage sites of MMP-2 and MMP-9 (gelatinase A and B) in collagen. After being hydrolyzed by collagenase, MMP-2/MMP-9 Substrate reacts with 4,4'-dithiodipyridine or Ellman's Reagent via its thiol fragment to produce a product with ultraviolet absorption properties .

HY-A0248AS

Polymyxin B1-d7 TFA	Isotope-Labeled Compounds Bacterial	Infection
Polymyxin B1-d₇ TFA is the deuterium labeled Polymyxin B1 TFA (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-W015198S

4-(Trifluoromethyl)benzoic acid-13C6	Isotope-Labeled Compounds	Others
4-(Trifluoromethyl)benzoic acid- ¹³C₆ is the ¹³C labeled 4-(Trifluoromethyl)benzoic acid .

HY-W011223

*(S)-2-((tert-Butoxycarbonyl)amino)-3-(4-(trifluoromethyl)phenyl)propanoic acid*	Amino Acid Derivatives	Others
(S)-2-((tert-Butoxycarbonyl)amino)-3-(4-(trifluoromethyl)phenyl)propanoic acid is a phenylalanine derivative .

HY-P2496

*Endothelin 1 (swine, human), Alexa Fluor* 488-labeled**	Endothelin Receptor Fluorescent Dye NF-κB COX Prostaglandin Receptor Apoptosis TNF Receptor Interleukin Related MMP	Cardiovascular Disease Inflammation/Immunology Cancer
Endothelin 1 (swine, human), Alexa Fluor 488-labeled is an Endothelin-1 conjugated with Alexa Fluor 488 (HY-D1304). Endothelin-1 is an endogenous vasoconstrictor and agonist of ETA/ETB receptor. Endothelin 1 (swine, human) exerts effects including promoting mitosis, angiogenesis, tumor invasion and metastasis, and inhibiting apoptosis. Endothelin 1 (swine, human) induces inflammation and oxidative stress by activating the NF-κB pathway. Endothelin 1 (swine, human), Alexa Fluor 488-labeled is specifically designed for fluorescence imaging, flow cytometry or receptor localization studies, and can be used in research related to sepsis, atherosclerosis, systemic inflammatory response syndrome, cancer and congestive heart failure .

HY-P5372A

Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 TFA	Protease Activated Receptor (PAR)	Cancer
Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 TFA, a bioactive peptide, is a selective Protease activating receptor 1 (PAR-1) agonist over PAR-2. PAR-1 belongs to a subfamily of G-protein coupled receptors and is known to mediate the cellular effects of thrombin. In addition to its varied cellular effects of thrombin, PAR-1 has also been shown to coordinate with PAR-4 and regulate thrombin-induced hepatocellular carcinoma harboring thrombin formation within the tumor environment classified as 'coagulation type' .

HY-77324R

4-(Trifluoromethyl)aniline (Standard) 4-Aminobenzotrifluoride (Standard)	Reference Standards
4-(Trifluoromethyl)aniline (Standard) is the analytical standard of 4-(Trifluoromethyl)aniline. This product is intended for research and analytical applications.

HY-W015198

4-(Trifluoromethyl)benzoic acid	Biochemical Assay Reagents	Others
4-(Trifluoromethyl)benzoic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P10563

Noraramtide BHV-1100	CD38	Cancer
Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to CD38 molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity .

HY-77324S

4-(Trifluoromethyl)aniline-d4 4-Aminobenzotrifluoride-d₄	DYRK	Cancer
4-(Trifluoromethyl)aniline-d₄ (4-Aminobenzotrifluoride-d₄) is deuterium labeled 4-(Trifluoromethyl)aniline. 4-(Trifluoromethyl)aniline is a DYRK1A and DYRK1B kinase inhibitor with IC₅₀s of 54.84 nM and 186.40 nM, respectively .

HY-42549

*N-[4-(Trifluoromethyl)benzyl]piperazine*	Drug Intermediate	Others
N-[4-(Trifluoromethyl)benzyl]piperazine is a drug intermediate for synthesis of various active compounds.

HY-W013504S

*1-Bromo-4-(trifluoromethyl)benzene-d4* 4-Bromo-α,α,α-trifluorotoluene-d₄	Isotope-Labeled Compounds	Others
1-Bromo-4-(trifluoromethyl)benzene-d₄ is the deuterium labeled 1-Bromo-4-(trifluoromethyl)benzene .

HY-W158239

*4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylic acid*	Drug Metabolite	Others
4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylic acid is a metabolite of GW 501516 (HY-10838) .

HY-W011235S

Norfluoxetine-d5 hydrochloride	Calcium Channel 5-HT Receptor Drug Metabolite Isotope-Labeled Compounds	Others
Norfluoxetine-d₅ (hydrochloride) is deuterium labeled 3-Phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-amine hydrochloride.

HY-P3066

SKF 100398 d(CH2)5Tyr(Et)VAVP	Vasopressin Receptor	Metabolic Disease
SKF 100398 (d(CH2)5Tyr(Et)VAVP), an arginine vasopressin (AVP) analogue, is a specific antagonist of the antidiuretic effect of exogenous and endogenous AVP .

HY-W019715

*trans-4-(Trifluoromethyl)cinnamic acid*	Drug Derivative	Others
trans-4-(Trifluoromethyl)cinnamic acid is a Phenylpropanoids product that can be isolated from the barks of Cinnamomum cassia Presl .

HY-75513

*2-Amino-4-(trifluoromethyl)pyridine*	Biochemical Assay Reagents	Others
2-Amino-4-(trifluoromethyl)pyridine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P10828

MAPI	Virus Protease	Infection Inflammation/Immunology
MAPI is a polypeptide irreversible 3C cysteine protease (SV3CP) inhibitor. MAPI inhibits SV3CP by covalently binding its C-terminal Michael-acceptor extension to the active site thiol of SV3CP Cys 139. MAPI is promising for research of noroviruses infection .

HY-P5372

Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2	Protease Activated Receptor (PAR)	Cancer
Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2, a bioactive peptide, is a selective Protease activating receptor 1 (PAR-1) agonist over PAR-2. PAR-1 belongs to a subfamily of G-protein coupled receptors and is known to mediate the cellular effects of thrombin. In addition to its varied cellular effects of thrombin, PAR-1 has also been shown to coordinate with PAR-4 and regulate thrombin-induced hepatocellular carcinoma harboring thrombin formation within the tumor environment classified as 'coagulation type' .

HY-163915

*8-(4-(Trifluoromethyl)anilino)quercetin*	Bacterial Antibiotic TNF Receptor	Inflammation/Immunology
8-(4-(Trifluoromethyl)anilino)quercetin is a potent ErmA inhibitor. 8-(4-(Trifluoromethyl)anilino)quercetin has antioxidant and anti-inflammatory activity .

HY-W141899

4-(Trifluoromethyl)-L-phenylglycine	Amino Acid Derivatives	Others
4-(Trifluoromethyl)-L-phenylglycine is a Glycine (HY-Y0966) derivative .

HY-W142047

*Boc-(R)-4-[4-(trifluoromethyl)benzyl]-L-proline*	Amino Acid Derivatives	Others
Boc-(R)-4-[4-(trifluoromethyl)benzyl]-L-proline is a proline derivative .

HY-152337

*2’-Chloro-N6-(4-trifluoromethyl)benzyl adenosine*	Nucleoside Antimetabolite/Analog	Cancer
2’-Chloro-N6-(4-trifluoromethyl)benzyl adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

HY-152395

*N-[[4-(Trifluoromethyl)phenyl]methyl]adenosine*	Nucleoside Antimetabolite/Analog	Cancer
N-[[4-(Trifluoromethyl)phenyl]methyl]adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) .

HY-W662572S

Pyroxsulam-d6 N-(5,7-Dimethoxy-d₆[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-2-methoxy-4-(trifluoromethyl)pyridine-3-sulfonamide	Isotope-Labeled Compounds	Others
Pyroxsulam-d₆ (N-(5,7-Dimethoxy-d₆[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-2-methoxy-4-(trifluoromethyl)pyridine-3-sulfonamide) is deuterium labeled N-(5,7-Dimethoxy-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-2-methoxy-4-(trifluoromethyl)pyridine-3-sulfonamide .

HY-W010153S

*3-(Trifluoromethyl)phenol-d4* α,α,α-Trifluoro-m-cresol-d₄	Isotope-Labeled Compounds	Others
3-(Trifluoromethyl)phenol-d₄ is the deuterium labeled 3-(Trifluoromethyl)phenol .

HY-163847

Anti-osteoporosis agent-9	MMP Cathepsin	Inflammation/Immunology
Anti-osteoporosis agent-9 (compound 5b) is a N-cyclopropyl-4-((4-((4-(trifluoromethyl)phenyl)sulfonyl)piperazin-1-yl)methyl)benzamide derivative that shows anti-osteoclast activity .

HY-W654191

Fipronil detrifluoromethylsulfinyl-13C2,15N2	Isotope-Labeled Compounds	Others
Fipronil detrifluoromethylsulfinyl- ¹³C2, ¹⁵N₂ is ¹³C and ¹⁵N labeled 5-Amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile .

HY-P2592

Ro 23-7014	Cholecystokinin Receptor	Others
Ro 23-7014 is an appetite suppressant. Ro 23-7014 is an analog of cholecystokinin (CCK-7) .

HY-125628

Kahalalide A	Endogenous Metabolite	Infection
Kahalalide A is an anti-mycobacterial compound with antimicrobial activity. Kahalalide A is derived from the marine mollusk Elysia rufescens. Kahalalide A has attracted extensive attention in natural product research due to its potential medicinal value .

HY-W019715R

*trans-4-(Trifluoromethyl)cinnamic acid (Standard)*	Others Reference Standards	Others
trans-4-(Trifluoromethyl)cinnamic acid (Standard) is the analytical standard of trans-4-(Trifluoromethyl)cinnamic acid (HY-W019715). This product is intended for research and analytical applications. trans-4-(Trifluoromethyl)cinnamic acid is a Phenylpropanoids product that can be isolated from the barks of Cinnamomum cassia Presl .

HY-78861R

*2-Cyano-N-[4-(trifluoromethyl)phenyl]acetamide (Standard)*	Reference Standards
2-Cyano-N-[4-(trifluoromethyl)phenyl]acetamide (Standard) is the analytical standard of 2-Cyano-N-[4-(trifluoromethyl)phenyl]acetamide. This product is intended for research and analytical applications.

HY-23507R

*5-Methoxy-1-(4-(trifluoromethyl)phenyl)pentan-1-one (Standard)*	Reference Standards
5-Methoxy-1-(4-(trifluoromethyl)phenyl)pentan-1-one (Standard) is the analytical standard of 5-Methoxy-1-(4-(trifluoromethyl)phenyl)pentan-1-one. This product is intended for research and analytical applications.

HY-W543638

*2,6-Bis(pyridin-4-ylethynyl)-4-(trifluoromethyl)aniline*	MOFs	Others
2,6-Bis(pyridin-4-ylethynyl)-4-(trifluoromethyl)aniline is a metal-organic framework (MOF).

Cat. No.	상품명	Target	Research Area

HY-134124

*Glutathione ethyl* ester**	Reactive Oxygen Species (ROS)	Metabolic Disease
Glutathione ethyl ester is a cell-permeable GSH donor and provides an efficient supply of GSH to the oocyte. Glutathione ethyl ester shows positive effect on the in vitro production of embryos by enhancement of the antioxidative defense .

HY-P10272

Rusfertide PTG-300	Ferroportin	Others
Rusfertide is a peptide mimetic of natural hepcidin, which targets and degrades ferroportin, reduces serum iron and transferrin-saturation, and thus regulates the production of red blood cells. Rusfertide ameliorates the polycythemia vera, β-thalassemia and hereditary hemochromatosis .

HY-A0248A

Polymyxin B1 1 Publications Verification	Bacterial	Infection
Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-W013962

4-(Trifluoromethyl)-L-phenylalanine 1 Publications Verification	Amino Acid Derivatives	Others
4-(Trifluoromethyl)-L-phenylalanine is a phenylalanine derivative .

HY-P1108A

Astressin 2B TFA 1 Publications Verification	CRFR	Neurological Disease Inflammation/Immunology
Astressin 2B TFA is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist (rCRFR2, IC₅₀=0.57 nM). Astressin 2B TFA blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin (HY-14397)-induced hemorrhagic intestinal injury in rats. Astressin 2B TFA reverses the protective effects of Urocortin 1 against intestinal hypermotility, bacterial invasion and upregulation of inflammatory mediators. Astressin 2B TFA also blocks the anxiogenic effect of Urocortin 2 and attenuates stress-induced anxiety-related behaviors. In the Clostridioides difficile toxin A (C. difficile toxin A)-mediated enteritis model, Astressin 2B TFA mimics the phenotype of CRFR2-deficient mice, significantly exacerbating intestinal epithelial damage, edema, neutrophil migration and the expression of multiple proinflammatory cytokines. Astressin 2B TFA is an important tool molecule for investigating the intestinal protective mechanisms of CRFR2 ^[4] .

HY-P1108

Astressin 2B 1 Publications Verification	CRFR	Neurological Disease Inflammation/Immunology
Astressin 2B is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist (rCRFR2, IC₅₀=0.57 nM). Astressin 2B blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin (HY-14397)-induced hemorrhagic intestinal injury in rats. Astressin 2B reverses the protective effects of Urocortin 1 against intestinal hypermotility, bacterial invasion and upregulation of inflammatory mediators. Astressin 2B also blocks the anxiogenic effect of Urocortin 2 and attenuates stress-induced anxiety-related behaviors. In the Clostridioides difficile toxin A (C. difficile toxin A)-mediated enteritis model, Astressin 2B mimics the phenotype of CRFR2-deficient mice, significantly exacerbating intestinal epithelial damage, edema, neutrophil migration and the expression of multiple proinflammatory cytokines. Astressin 2B is an important tool molecule for investigating the intestinal protective mechanisms of CRFR2 ^[4] .

HY-P10143

MMP-2/MMP-9 Substrate Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt	MMP	Others
MMP-2/MMP-9 Substrate (Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt) is a synthetic chromogenic polypeptide substrate whose core structure mimics the cleavage sites of MMP-2 and MMP-9 (gelatinase A and B) in collagen. After being hydrolyzed by collagenase, MMP-2/MMP-9 Substrate reacts with 4,4'-dithiodipyridine or Ellman's Reagent via its thiol fragment to produce a product with ultraviolet absorption properties .

HY-A0248AS

Polymyxin B1-d7 TFA	Isotope-Labeled Compounds Bacterial	Infection
Polymyxin B1-d₇ TFA is the deuterium labeled Polymyxin B1 TFA (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-W011223

*(S)-2-((tert-Butoxycarbonyl)amino)-3-(4-(trifluoromethyl)phenyl)propanoic acid*	Amino Acid Derivatives	Others
(S)-2-((tert-Butoxycarbonyl)amino)-3-(4-(trifluoromethyl)phenyl)propanoic acid is a phenylalanine derivative .

HY-P2496

*Endothelin 1 (swine, human), Alexa Fluor* 488-labeled**	Endothelin Receptor Fluorescent Dye NF-κB COX Prostaglandin Receptor Apoptosis TNF Receptor Interleukin Related MMP	Cardiovascular Disease Inflammation/Immunology Cancer
Endothelin 1 (swine, human), Alexa Fluor 488-labeled is an Endothelin-1 conjugated with Alexa Fluor 488 (HY-D1304). Endothelin-1 is an endogenous vasoconstrictor and agonist of ETA/ETB receptor. Endothelin 1 (swine, human) exerts effects including promoting mitosis, angiogenesis, tumor invasion and metastasis, and inhibiting apoptosis. Endothelin 1 (swine, human) induces inflammation and oxidative stress by activating the NF-κB pathway. Endothelin 1 (swine, human), Alexa Fluor 488-labeled is specifically designed for fluorescence imaging, flow cytometry or receptor localization studies, and can be used in research related to sepsis, atherosclerosis, systemic inflammatory response syndrome, cancer and congestive heart failure .

HY-P5372A

Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 TFA	Protease Activated Receptor (PAR)	Cancer
Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 TFA, a bioactive peptide, is a selective Protease activating receptor 1 (PAR-1) agonist over PAR-2. PAR-1 belongs to a subfamily of G-protein coupled receptors and is known to mediate the cellular effects of thrombin. In addition to its varied cellular effects of thrombin, PAR-1 has also been shown to coordinate with PAR-4 and regulate thrombin-induced hepatocellular carcinoma harboring thrombin formation within the tumor environment classified as 'coagulation type' .

HY-P10563

Noraramtide BHV-1100	CD38	Cancer
Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to CD38 molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity .

HY-P3066

SKF 100398 d(CH2)5Tyr(Et)VAVP	Vasopressin Receptor	Metabolic Disease
SKF 100398 (d(CH2)5Tyr(Et)VAVP), an arginine vasopressin (AVP) analogue, is a specific antagonist of the antidiuretic effect of exogenous and endogenous AVP .

HY-P10828

MAPI	Virus Protease	Infection Inflammation/Immunology
MAPI is a polypeptide irreversible 3C cysteine protease (SV3CP) inhibitor. MAPI inhibits SV3CP by covalently binding its C-terminal Michael-acceptor extension to the active site thiol of SV3CP Cys 139. MAPI is promising for research of noroviruses infection .

HY-P5373

Ser-parafluoroPhe-Aad-Leu-Arg-Asn-Pro-NH2	Peptides	Others
Ser-parafluoroPhe-Aad-Leu-Arg-Asn-Pro-NH2 is a biological active peptide. (Structure-activity studies of thrombin receptor-tethered ligand SFLLRNP have revealed the importance of the Phe-2-phenyl group in receptor recognition and the replacement of the Phe-2 by para-fluorophenylalanine [(p-F)Phe] was found to enhance its activity)

HY-P5372

Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2	Protease Activated Receptor (PAR)	Cancer
Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2, a bioactive peptide, is a selective Protease activating receptor 1 (PAR-1) agonist over PAR-2. PAR-1 belongs to a subfamily of G-protein coupled receptors and is known to mediate the cellular effects of thrombin. In addition to its varied cellular effects of thrombin, PAR-1 has also been shown to coordinate with PAR-4 and regulate thrombin-induced hepatocellular carcinoma harboring thrombin formation within the tumor environment classified as 'coagulation type' .

HY-W141899

4-(Trifluoromethyl)-L-phenylglycine	Amino Acid Derivatives	Others
4-(Trifluoromethyl)-L-phenylglycine is a Glycine (HY-Y0966) derivative .

HY-W142047

*Boc-(R)-4-[4-(trifluoromethyl)benzyl]-L-proline*	Amino Acid Derivatives	Others
Boc-(R)-4-[4-(trifluoromethyl)benzyl]-L-proline is a proline derivative .

HY-P4756

*N-(2-Carbamoyl-ethyl)-Val-Leu-anilide*	Peptides	Others
N-(2-Carbamoyl-ethyl)-Val-Leu-anilide is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P2592

Ro 23-7014	Cholecystokinin Receptor	Others
Ro 23-7014 is an appetite suppressant. Ro 23-7014 is an analog of cholecystokinin (CCK-7) .

HY-125628

Kahalalide A	Endogenous Metabolite	Infection
Kahalalide A is an anti-mycobacterial compound with antimicrobial activity. Kahalalide A is derived from the marine mollusk Elysia rufescens. Kahalalide A has attracted extensive attention in natural product research due to its potential medicinal value .

HY-A0248AS1

Polymyxin B1-D-Leu-d7 TFA	Isotope-Labeled Compounds Bacterial	Infection
Polymyxin B1-D-Leu-d₇ TFA is the deuterium labeled Polymyxin B1 (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

Cat. No.	상품명	Category	Target	Chemical Structure

HY-A0248A

Polymyxin B1 1 Publications Verification	Infection Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial
Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-112731

TFAP N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	COX Endogenous Metabolite
TFAP is a selective cyclooxygenase-1 (COX-1) inhibitor, with an IC₅₀ of 0.8 μM.

HY-A0248AS

Polymyxin B1-d7 TFA	Structural Classification Microorganisms Antibiotics Antibacterial Disease Research Other Antibiotics Source Classification	Isotope-Labeled Compounds Bacterial
Polymyxin B1-d₇ TFA is the deuterium labeled Polymyxin B1 TFA (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-W019715

*trans-4-(Trifluoromethyl)cinnamic acid*	Structural Classification Cinnamomum cassia (L.) D. Don Phenylpropanoids Plants Lauraceae Source Classification	Drug Derivative
trans-4-(Trifluoromethyl)cinnamic acid is a Phenylpropanoids product that can be isolated from the barks of Cinnamomum cassia Presl .

HY-W019715R

*trans-4-(Trifluoromethyl)cinnamic acid (Standard)*	Structural Classification Cinnamomum cassia (L.) D. Don Phenylpropanoids Plants Lauraceae Source Classification	Others Reference Standards
trans-4-(Trifluoromethyl)cinnamic acid (Standard) is the analytical standard of trans-4-(Trifluoromethyl)cinnamic acid (HY-W019715). This product is intended for research and analytical applications. trans-4-(Trifluoromethyl)cinnamic acid is a Phenylpropanoids product that can be isolated from the barks of Cinnamomum cassia Presl .

HY-A0248AS1

Polymyxin B1-D-Leu-d7 TFA	Structural Classification Microorganisms Antibiotics Antibacterial Disease Research Other Antibiotics Source Classification	Isotope-Labeled Compounds Bacterial
Polymyxin B1-D-Leu-d₇ TFA is the deuterium labeled Polymyxin B1 (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

Cat. No.	상품명	Chemical Structure

HY-A0248AS

Polymyxin B1-d7 TFA

Polymyxin B1-d₇ TFA is the deuterium labeled Polymyxin B1 TFA (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-W015198S

4-(Trifluoromethyl)benzoic acid-13C6
4-(Trifluoromethyl)benzoic acid- ¹³C₆ is the ¹³C labeled 4-(Trifluoromethyl)benzoic acid .

HY-77324S

4-(Trifluoromethyl)aniline-d4
4-(Trifluoromethyl)aniline-d₄ (4-Aminobenzotrifluoride-d₄) is deuterium labeled 4-(Trifluoromethyl)aniline. 4-(Trifluoromethyl)aniline is a DYRK1A and DYRK1B kinase inhibitor with IC₅₀s of 54.84 nM and 186.40 nM, respectively .

HY-W013504S

*1-Bromo-4-(trifluoromethyl)benzene-d4*
1-Bromo-4-(trifluoromethyl)benzene-d₄ is the deuterium labeled 1-Bromo-4-(trifluoromethyl)benzene .

HY-W011235S

Norfluoxetine-d5 hydrochloride
Norfluoxetine-d₅ (hydrochloride) is deuterium labeled 3-Phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-amine hydrochloride.

HY-W662572S

Pyroxsulam-d6
Pyroxsulam-d₆ (N-(5,7-Dimethoxy-d₆[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-2-methoxy-4-(trifluoromethyl)pyridine-3-sulfonamide) is deuterium labeled N-(5,7-Dimethoxy-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-2-methoxy-4-(trifluoromethyl)pyridine-3-sulfonamide .

HY-W010153S

*3-(Trifluoromethyl)phenol-d4*
3-(Trifluoromethyl)phenol-d₄ is the deuterium labeled 3-(Trifluoromethyl)phenol .

HY-W654191

Fipronil detrifluoromethylsulfinyl-13C2,15N2
Fipronil detrifluoromethylsulfinyl- ¹³C2, ¹⁵N₂ is ¹³C and ¹⁵N labeled 5-Amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile .

HY-166873S

Fluvoxamine-d3
Fluvoxamine-d₃ is deuterium labeled (Z)-5-Methoxy-1-(4-(trifluoromethyl)phenyl)pentan-1-one O-(2-aminoethyl) oxime (Fluvoxamine Impurity) .

HY-A0248AS1

Polymyxin B1-D-Leu-d7 TFA

Polymyxin B1-D-Leu-d₇ TFA is the deuterium labeled Polymyxin B1 (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

Cat. No.	상품명		Classification

HY-152337

*2’-Chloro-N6-(4-trifluoromethyl)benzyl adenosine*		Nucleoside Analogs Adenosine
2’-Chloro-N6-(4-trifluoromethyl)benzyl adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

HY-152395

*N-[[4-(Trifluoromethyl)phenyl]methyl]adenosine*		Nucleoside Analogs Adenosine
N-[[4-(Trifluoromethyl)phenyl]methyl]adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) .

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