1. Immunology/Inflammation
    Metabolic Enzyme/Protease
  2. COX
    Endogenous Metabolite

TFAP (Synonyms: N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide)

Cat. No.: HY-112731 Purity: 99.97%
Handling Instructions

TFAP is a selective cyclooxygenase-1 (COX-1) inhibitor, with an IC50 of 0.8 μM.

For research use only. We do not sell to patients.

TFAP Chemical Structure

TFAP Chemical Structure

CAS No. : 1011244-68-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 99 In-stock
Estimated Time of Arrival: December 31
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 140 In-stock
Estimated Time of Arrival: December 31
50 mg USD 490 In-stock
Estimated Time of Arrival: December 31
100 mg USD 790 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

TFAP is a selective cyclooxygenase-1 (COX-1) inhibitor, with an IC50 of 0.8 μM.

IC50 & Target

COX-1

0.8 μM (IC50)

Human Endogenous Metabolite

 

In Vitro

TFAP is a selective cyclooxygenase-1 (COX-1) inhibitor, with an IC50 of 0.8 μM, while that against COX-2 is over 200 μM.

Solvent & Solubility
In Vitro: 

DMSO : ≥ 155 mg/mL (551.15 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5558 mL 17.7790 mL 35.5581 mL
5 mM 0.7112 mL 3.5558 mL 7.1116 mL
10 mM 0.3556 mL 1.7779 mL 3.5558 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.58 mg/mL (9.17 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.58 mg/mL (9.17 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: 2.58 mg/mL (9.17 mM); Clear solution; Need warming

References
Molecular Weight

281.23

Formula

C₁₃H₁₀F₃N₃O

CAS No.

1011244-68-0

SMILES

O=C(NC1=NC=C(N)C=C1)C2=CC=C(C(F)(F)F)C=C2

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
TFAP
Cat. No.:
HY-112731
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TFAP

Cat. No.: HY-112731