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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
41 Results for "
Aβ-IN-7
" in MedChemExpress (MCE) Product Catalog:
Products (41)
41 Results for "Aβ-IN-7" in MCE Product Catalog:
Cat. No.: HY-149582
CAS No.: 69791-41-9
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Aβ-IN-7 (compound 5a) is a potent inhibitor of the Aβ aggregation. Aβ-IN-7 with 50 μM stabilize Aβ monomers in the small oligomeric species and prolong the nucleation process. Aβ-IN-7 inhibits Aβ fibril formation better than Aβ-IN-8 (HY-149583) in 50 μM .
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GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6 nM and 16 nM, respectively, which leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation (EC50 of 0.66 μM for mouse β (R7T1) cells) .
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1 Cited Publications
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Cat. No.: HY-P0179
CAS No.: 72122-62-4
Synonyms: β-CasomorphIN-7 (bovINe); BovINe β-casomorphIN-7
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Cat. No.: HY-P1481A
Synonyms: Human β-casomorphIN 7 TFA
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Cat. No.: HY-168737
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NEK7-IN-2 is a NEK7 inhibitor. NEK7-IN-2 increases the thermal stability of NEK7, disrupts the NEK7-NLRP3 interaction, inhibits NLRP3 inflammasome assembly, and suppresses the release of IL-1β (with an IC50 of 0.048 μM against IL-1β). NEK7-IN-2 can be used for the research of inflammatory diseases .
Cat. No.: HY-N10493
CAS No.: 64907-21-7
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Cat. No.: HY-P99527
CAS No.: 886584-10-7
Synonyms: ACC-001; PF 05236806
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Cat. No.: HY-169238
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17β-HSD7-IN-1 (compound 4) is an inhibitor of 17β-HSD7, with inhibitory effect agasint the formation of Estradiol (IC50=63 nM). .
Cat. No.: HY-146793S
CAS No.: 2342573-92-4
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3β-Hydroxy-7-oxocholest-5-enoic acid-d3 is deuterium labeled 3β-Hydroxy-7-oxocholest-5-enoic acid.
Cat. No.: HY-143261
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GSK-3β inhibitor 7 is a GSK-3β inhibitor with an IC50 value of 5.25 μM. GSK-3β inhibitor 7 is inserted into the ATP-binding binding pocket of GSK-3β and forms hydrogen-bond. GSK-3β inhibitor 7 shows high hepatocyte glucose uptake (83.5%), and can be used in the research of numerous diseases like diabetes, inflammation, cancer, Alzheimer's disease, and bipolar disorder .
Cat. No.: HY-146760S
CAS No.: 2315262-18-9
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C15 Glucosyl(β) ceramide-d7 is deuterium labeled C15 Glucosyl(β) ceramide.
Cat. No.: HY-181837
CAS No.: 3117527-92-8
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IKKβ-IN-7 is an IKKβ inhibitor with an IC50 value of 9.44 μM. IKKβ-IN-7 induces DNA damage, S-phase cell cycle arrest, ROS accumulation, mitochondrial membrane potential loss, and apoptosis. IKKβ-IN-7 inhibits phosphorylation of p65 and IκBα, suppresses p65 nuclear translocation, and regulates NF-κB-controlled genes. IKKβ-IN-7 suppresses tumor growth in xenograft models and shows activity against colorectal cancer with low normal cell cytotoxicity. IKKβ-IN-7 can be used for the research of colorectal cancer .
Cat. No.: HY-164568
CAS No.: 773133-78-1
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7β,16α-Dihydroxybufalin is a dihydroxylated derivative of bufalin, which exhibits cytotoxicities against cancer cell lines .
Cat. No.: HY-N15128
CAS No.: 64687-85-0
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Cat. No.: HY-N15129
CAS No.: 64687-84-9
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Cat. No.: HY-N15534
CAS No.: 1380443-06-0
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Cat. No.: HY-P0179A
Synonyms: β-CasomorphIN-7 (bovINe) TFA; BovINe β-casomorphIN-7 TFA
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Cat. No.: HY-N8667
CAS No.: 87261-77-6
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
