69791-41-9
69791-41-9
Chemical Structure
Aβ-IN-7
- CAS No.: 69791-41-9
- Formula:C14H10N2S
- Molecular Weight:238.31
InChIKey: SBRCQCMQXNSPJR-XNTDXEJSSA-N
SMILES: C1(/C=N/C2=NC3=CC=CC=C3S2)=CC=CC=C1
Biological Activity: Aβ-IN-7 (compound 5a) is a potent inhibitor of the Aβ aggregation. Aβ-IN-7 with 50 μM stabilize Aβ monomers in the small oligomeric species and prolong the nucleation process. Aβ-IN-7 inhibits Aβ fibril formation better than Aβ-IN-8 (HY-149583) in 50 μM[1].
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Aβ-IN-7 | Aβ-IN-7 (compound 5a) is a potent inhibitor of the Aβ aggregation. Aβ-IN-7 with 50 μM stabilize Aβ monomers in the small oligomeric species and prolong the nucleation process. Aβ-IN-7 inhibits Aβ fibril formation better than Aβ-IN-8 (HY-149583) in 50 μM. | |||||||||||||||||||||
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References
- [1]. Mohammad Hossein Asgarshamsi, et al. Synthesis of Some Benzothiazole Derivatives Based on 3-Hydroxypyridine-4-one and Benzaldehyde and Evaluation of Their β-Amyloid Aggregation Inhibition Using both Experimental Methods and Molecular Dynamic Simulation. Chem Biodivers. 2023 Sep 10:e202301113. [Content Brief]
Keywords
