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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
ALKBH3
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "ALKBH3" in MCE Product Catalog:
Cat. No.: HY-174979
CAS No.: 3084407-00-8
Research Areas:
Dac590 is an orally active and selective obesity-associated protein (FTO) inhibitor with an IC50 of 6.06 nM. Dac590 shows highly selective over ALKBH5 and ALKBH3. Dac590 suppresses oncogenic FTO signaling, induces myeloid differentiation, G1-phase cell cycle arrest, and apoptosis in acute myeloid leukemia (AML) cells. Dac590 inhibits xenograft tumor growth and prolongs survival in acute myeloid leukemia mouse models with no observed toxicity. Dac590 can be used for the research of AML .
Cat. No.: HY-173020
CAS No.: 3035498-92-8
Research Areas:
W23-1006 is a selective and covalent ALKBH5 inhibitor. W23-1006 binds to the ALKBH5 C200 residue with an IC50 value of 3.848 μM. W23-1006 shows ~30- and 8-fold stronger inhibitory activity than that against FTO and ALKBH3, respectively. W23-1006 can be used for the study of triple-negative breast cancer (TNBC) .
Cat. No.: HY-RS00605
Target:
Research Areas:
ALKBH3 Human Pre-designed siRNA Set A contains three designed siRNAs for ALKBH3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17256
Target:
Research Areas:
Alkbh3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Alkbh3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23710
Target:
Research Areas:
Alkbh3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Alkbh3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-179266
Research Areas:
FTO-IN-15 (Compound 8a) is a potent and selective dual-competitive FTO inhibitor with an IC50 of 43.7 nM, showing high selectivity over ALKBH3 and ALKBH5. FTO-IN-15 substantially inhibits FTO demethylation by simultaneously occupying the substrate and 2-oxoglutarate (2-OG) pockets. FTO-IN-15 can be used for the research of acute myeloid leukemia (AML) .
Cat. No.: HY-100199R
CAS No.: 1453097-13-6
Target:
Research Areas:
HUHS015 (Standard) is the analytical standard of HUHS015 (HY-100199). This product is intended for research and analytical applications. HUHS015 is a potent prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitor with an IC50 of 0.67μM for PCA-1 .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
