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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
AMG8380
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "AMG8380" in MCE Product Catalog:
Cat. No.: HY-108425B
CAS No.: 1641574-26-6
Synonyms: (Rac)-AMG8380
Target:
Research Areas:
(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379. AMG8379 is a potent, orally active and selective sulfonamide antagonist of NaV1.7, with IC50s of 8.5 and 18.6 nM for hNaV1.7 and mNaV1.7, respectively .
Cat. No.: HY-108425A
CAS No.: 1642112-32-0
Target:
Research Areas:
AMG8380, an orally active and less active enantiomer of AMG8379, can serves as a negative control. AMG8380 inhibits human and mouse voltage-gated sodium channel NaV1.7 with IC50s of 0.907 and 0.387 μM, respectively. AMG8380 blocks Tetrodotoxin (TTX)-sensitive native channels with an IC50 of 2560 nM .
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Protocols
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