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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
Acetyl-CoA synthetase
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "Acetyl-CoA synthetase" in MCE Product Catalog:
Target:
Research Areas:
Acetyl-CoA synthetase (ACS) is a key enzyme that catalyzes the conversion of acetic acid to acetyl-CoA (Ac-CoA). Acetyl-CoA synthetase catalyzes the formation of a thioester bond between coenzyme A and carboxylic acid, while hydrolyzing ATP to AMP and pyrophosphate. Acetyl-CoA synthetase has two mammalian isoforms, mediates the only pathway for the conversion of free acetic acid to acetyl-CoA in mammals, serves as a marker gene for the Wood-Ljungdahl pathway, and catalyzes the exchange between carbonyl groups and CoA-acetyl-CoA. Acetyl-CoA synthetase can be used for studies of metabolism-related diseases .
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9 Cited Publications
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Ac-CoA Synthase-IN-1 is a potent, reversible acetate-dependent acetyl-CoA synthetase 2 (ACSS2) inhibitor with an IC50 of 0.6 μM . Ac-CoA Synthase-IN-1 inhibits the respiratory syncytial virus (RSV) .
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1 Cited Publications
Cat. No.: HY-P701923
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ACSS2; Acetyl-Coenzyme A synthetase 2 (ADP Forming); Prev. ACAS2; Acetyl-CoA synthetase; AceCS; Acetate--CoA Ligase; ACS; AceCS1; Acetyl-Coenzyme A synthetase, Cytoplasmic; CDNA FLJ53719, Highly Similar To Acetyl-Coenzyme A synthetase, Cytoplasmic (EC6.2.
Species:
Human
Source:
E. coli
Cat. No.: HY-E70277
CAS No.: 71425-89-3
Research Areas:
Hexadecyl-CoA is a non-hydrolyzable thioether analog of Palmitoyl-CoA. Hexadecyl-CoA competitively inhibits the acyl-CoA thioesterase activity of HNF-4α with a Ki of 0.3 μM, and inhibits DGAT2 activity with an IC50 of approximately 2 μM. Hexadecyl-CoA also inhibits ATGL activity and serves as a reference inhibitor for DGAT2 LC/MS enzyme activity assays. Hexadecyl-CoA can be used in studies related to lipid metabolism, triglyceride synthesis and lipolysis .
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Pyruvate Oxidase, Microorganisms (PoxB) is a peripheral membrane enzyme, isolated from microorganisms. Pyruvate oxidase catalyzes the oxidative decarboxylation of pyruvate to acetyl phosphate, carbon dioxide and water. Pyruvate oxidase is an important enzyme in bacterial metabolism and is often used in biochemical research .
Cat. No.: HY-145392
CAS No.: 2711039-08-4
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ACSS2-IN-1 is a potent acetyl-CoA synthetase 2 (ACSS2) inhibitor with an IC50 of <1 nM. ACSS2-IN-1 inhibits ACSS2 enzymatic activity, blocks the metabolic pathway converting acetate to acetyl-CoA in cancer cells, and thereby suppresses tumor energy metabolism, lipid synthesis and histone acetylation. ACSS2-IN-1 can be used in the research of cancer and hyperproliferative disorders .
Cat. No.: HY-181784
Ac-CoA-IN-1 is an acyl-AMP phosphate analog and weak inhibitor of Candida albicans acetyl-CoA synthetase 2, with no activity against Cryptococcus neoformans acetyl-CoA synthetase 1. Ac-CoA-IN-1 crystallizes with Cryptococcus neoformans ACS1 enzyme to yield structural insight for inhibitor design. Ac-CoA-IN-1 can be used for the research of fungal infections .
Cat. No.: HY-P701922
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ACSS2; Acetyl-Coenzyme A synthetase 2 (ADP Forming); Prev. ACAS2; Acetyl-CoA synthetase; AceCS; Acetate--CoA Ligase; ACS; AceCS1; Acetyl-Coenzyme A synthetase, Cytoplasmic; CDNA FLJ53719, Highly Similar To Acetyl-Coenzyme A synthetase, Cytoplasmic (EC6.2.
Species:
Human
Source:
E. coli
Cat. No.: HY-P71642
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ACSS2; Acetyl-Coenzyme A synthetase 2 (ADP Forming); Prev. ACAS2; Acetyl-CoA synthetase; AceCS; Acetate--CoA Ligase; ACS; AceCS1; Acetyl-Coenzyme A synthetase, Cytoplasmic; CDNA FLJ53719, Highly Similar To Acetyl-Coenzyme A synthetase, Cytoplasmic (EC6.2.
Species:
Mouse
Source:
E. coli
Cat. No.: HY-182685
CAS No.: 2446681-27-0
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MMV693183 is an orally active inhibitor of Plasmodium falciparum acetyl-CoA synthetase (AcAS), with an IC50 of 300 nM against Plasmodium falciparum. MMV693183 exhibits potent inhibitory activity against clinical isolates of malaria parasites, including Artemisinin (HY-B0094)-resistant strains. MMV693183 is metabolized in vivo into the active antimetabolite CoA-MMV693183, which exerts effects of killing asexual blood-stage parasites and blocking transmission to Anopheles mosquitoes by binding to and inhibiting the function of acetyl-CoA synthetase, thereby reducing the levels of acetyl-CoA and 4'-phosphopantetheine. In humanized mouse models, MMV693183 shows favorable in vivo efficacy, drug-like properties, and no significant cytotoxicity or off-target activity against human cells. MMV693183 is widely used in malaria-related research as a parasiticide and metabolic disruptor .
Cat. No.: HY-104032R
CAS No.: 508186-14-9
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Ac-CoA Synthase-IN-1 (Standard) is the analytical standard of Ac-CoA Synthase-IN-1 (HY-104032). This product is intended for research and analytical applications. Ac-CoA Synthase-IN-1 is a potent, reversible acetate-dependent acetyl-CoA synthetase 2 (ACSS2) inhibitor with an IC50 of 0.6 μM . Ac-CoA Synthase-IN-1 inhibits the respiratory syncytial virus (RSV) .
Cat. No.: HY-E71018
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S-Acetyl-coenzyme A synthetase, Baker's yeast (S. cerevisiae) (EC 6.2.1.1), catalyzes the production of acetyl-CoA and participates in the acetylation of histones in the cell nucleus.
Cat. No.: HY-P82238A
Synonyms: ACSS2; ACSA; ACAS2; AceCS; MYH7B; Acetyl CoA synthetase
Cat. No.: HY-P71851
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ACSS1; Acetyl-Coenzyme A synthetase 2 (AMP Forming)-Like; Prev. ACAS2L; Acetyl-Coenzyme A synthetase; AceCS2L; Acetyl-CoA synthetase 2; Acetyl-Coenzyme A synthetase 2-Like, Mitochondrial; Acetate--CoA Ligase; Propionate--CoA Ligase; KIAA1846; Acetate--CoA
Species:
Human
Source:
P. pastoris
Cat. No.: HY-P702154
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Biotin-[Acetyl-CoA carboxylase] synthetase; Biotin--protein ligase; EC:6.3.4.15; Biotin--[Acetyl-CoA-carboxylase] ligase; Biotin operon repressor; Bifunctional ligase/repressor BirA
Species:
E.coli
Source:
E. coli
Cat. No.: HY-P703428
Synonyms: Biotin-[Acetyl-CoA carboxylase] synthetase; Biotin--protein ligase; EC:6.3.4.15; Biotin--[Acetyl-CoA-carboxylase] ligase; Biotin operon repressor; Bifunctional ligase/repressor BirA
Species:
Others
Source:
E. coli
Cat. No.: HY-P75475
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Biotin-[Acetyl-CoA carboxylase] synthetase; Biotin--protein ligase; EC:6.3.4.15; Biotin--[Acetyl-CoA-carboxylase] ligase; Biotin operon repressor; Bifunctional ligase/repressor BirA
Species:
E.coli
Source:
E. coli
Cat. No.: HY-122476
CAS No.: 24125-28-8
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Leupeptin acid is a peptide byproduct present in the fermentation product of Streptomyces roseus MA839-A1, and also an intermediate in leupeptin biosynthesis. Leupeptin acid serves as a substrate for leupeptin acid reductase to generate Leupeptin (HY-18234) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
