71425-89-3
Chemical Structure
Hexadecyl-CoA
- CAS No.: 71425-89-3
- Formula:C37H68N7O16P3S
- Molecular Weight:991.96
InChIKey: HCCBNDDJPKNSLM-WOQKIVQTSA-N
SMILES: O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(OP(O)(OCC(C)([C@H](C(NCCC(NCCSCCCCCCCCCCCCCCCC)=O)=O)O)C)=O)=O)O[C@H]1N2C3=NC=NC(N)=C3N=C2
Biological Activity: Hexadecyl-CoA is a non-hydrolyzable thioether analog of Palmitoyl-CoA. Hexadecyl-CoA competitively inhibits the acyl-CoA thioesterase activity of HNF-4α with a Ki of 0.3 μM, and inhibits DGAT2 activity with an IC50 of approximately 2 μM. Hexadecyl-CoA also inhibits ATGL activity and serves as a reference inhibitor for DGAT2 LC/MS enzyme activity assays. Hexadecyl-CoA can be used in studies related to lipid metabolism, triglyceride synthesis and lipolysis[1][2][3].
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Hexadecyl-CoA | Hexadecyl-CoA is a non-hydrolyzable thioether analog of Palmitoyl-CoA. Hexadecyl-CoA competitively inhibits the acyl-CoA thioesterase activity of HNF-4α with a Ki of 0.3 μM, and inhibits DGAT2 activity with an IC50 of approximately 2 μM. Hexadecyl-CoA also inhibits ATGL activity and serves as a reference inhibitor for DGAT2 LC/MS enzyme activity assays. Hexadecyl-CoA can be used in studies related to lipid metabolism, triglyceride synthesis and lipolysis. | |||||||||||||||||||||
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References
- [1]. Nagy HM, et al. Adipose triglyceride lipase activity is inhibited by long-chain acyl-coenzyme A. Biochimica et biophysica acta. 2014 Apr 04;1841(4):588-94. [Content Brief]
- [2]. Hertz R, et al. Thioesterase activity and acyl-CoA/fatty acid cross-talk of hepatocyte nuclear factor-4{alpha}. The Journal of biological chemistry. 2005 Jul 01;280(26):24451-61.
- [3]. Song XS, et al. Identification of DGAT2 Inhibitors Using Mass Spectrometry. Journal of biomolecular screening. 2016 Feb;21(2):117-26.
