38 Results for "

Amyloid Beta/Aβ Antibody

" in MedChemExpress (MCE) Product Catalog:
Products (38)

38 Results for "Amyloid Beta/Aβ Antibody" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-P990110
Synonyms: Mab158

Target:  

Amyloid-β

Research Areas:  

Neurological Disease

Lecanemab (Mouse IgG2a) (Mab158) is a monoclonal antibody that targets soluble β-amyloid and has the potential to reduce cognitive decline. The variable region of Lecanemab (Mouse IGG2a) is consistent with that of Lecanemab, while the constant region is of Mouse IgG2a sequence. Lecanemab (Mouse IgG2a) almost abolishes Aβ accumulation in astrocytes and rescues neurons from Aβ-induced cell death. Lecanemab (Mouse IgG2a) holds promise for research in the field of Alzheimer's disease .
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1
1 Cited Publications
Cat. No.: HY-P99216
CAS No.: 1178862-65-1
Synonyms: PF-04360365; RN 1219

Target:  

Amyloid-β

Research Areas:  

Neurological Disease

Ponezumab (PF-04360365; RN 1219) is a humanized anti-amyloid-β (Amyloid-β) IgG2 monoclonal antibody. Ponezumab reduces Aβ levels in the central nervous system and improves the performance of mice in various learning and memory models. Ponezumab is applicable to the research of Alzheimer's disease .
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Cat. No.: HY-P9999
CAS No.: 2568868-35-7
Synonyms: RG6102; RO-7126209

Target:  

Amyloid-β

Research Areas:  

Neurological Disease

Trontinemab (RG6102) is a brain-penetrant, anti-amyloid, bispecific and humanizedized IgG1-κ antibody, targeting to Aβ plaques and transferrin receptor 1 (TFR1). Trontinemab binds to fibrillar Aβ as well as Aβ plaques triggering plaque clearance by engaging immune cells on Alzheimer disease (AD) brain sections. Trontinemab also shows specific affinity to cynomolgus and human TFR1 .
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Cat. No.: HY-P99859
CAS No.: 1931944-80-7
Synonyms: LY3002813

Target:  

Amyloid-β

Research Areas:  

Neurological Disease

Donanemab (LY3002813) is a humanized IgG1 monoclonal antibody directed at an N-terminal pyroglutamate amyloid beta (Aβ) epitope. Donanemab has the potential for early Alzheimer's disease research .
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Cat. No.: HY-P9967
CAS No.: 1384260-65-4
Synonyms: BIIB037

Target:  

Amyloid-β

Research Areas:  

Neurological Disease

Aducanumab (BIIB037) is a human monoclonal antibody that selectively targets aggregated amyloid-beta (Aβ). Aducanumab shows blood-brain-barrier penetration, and can be used for Alzheimer's disease (AD) research .
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Cat. No.: HY-P99317
CAS No.: 955085-14-0
Synonyms: LY-2062430

Target:  

Amyloid-β

Research Areas:  

Neurological Disease

Solanezumab (LY-2062430) is a humanized monoclonal IgG1 antibody directed against the mid-domain of the amyloid-β (Aβ) peptide. Solanezumab binds to the mid-domain of monomeric amyloid-beta to slow brain amyloid accumulation. Solanezumab can be used for the research of Alzheimer’s disease .
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Cat. No.: HY-P990109

Target:  

Amyloid-β

Research Areas:  

Neurological Disease

Aducanumab (Mouse IgG2a) is a monoclonal antibody that selectively targets aggregated amyloid-beta (Aβ). The variable region of Aducanumab (Mouse IgG2a) is consistent with that of Aducanumab (HY-P9967), while the constant region is of Mouse IGG2a sequence. Aducanumab (Mouse IgG2a) has strong selectivity for Aβ fibrils with EC50s of >1 μM and 0.2 nM for monomeric Aβ1-40 and fibrillar Aβ1-42, respectively. Aducanumab (Mouse IgG2a) can be used for Alzheimer's disease (AD) research .
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Cat. No.: HY-P99185
CAS No.: 648895-38-9
Synonyms: AAB-001
Research Areas:  

Neurological Disease

Bapineuzumab (AAB-001) is a humanized IgG1 monoclonal antibody that binds to the N-terminal region of amyloid beta in a helical conformation. Bapineuzumab induces microglial activation by upregulating CD11B, producing pro-inflammatory cytokines (IL-1β and TNFα), clearing plaques, and reducing insoluble and aggregated Aβ. Bapineuzumab can be used for research on Alzheimer's disease .
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Cat. No.: HY-P991413
ZEB85 is a human monoclonal antibody (mAb) targeting TrkB. ZEB85 activates TrkB and its downstream cascades, including the ERK, PLCγ, AKT, MAPK signaling pathways and cFOS expression, and enhances neuronal activity. ZEB85 prevents β-amyloid toxicity in cultured hippocampal neurons. ZEB85 is applicable to the research of Alzheimer's disease (AD) .
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Cat. No.: HY-P991480
ONC-841 is a blood-brain barrier-permeable, humanized monoclonal antibody targeting SIGLEC10. As an immune checkpoint inhibitor, ONC-841 restores the functions of immune effector cells such as T cells and enhances anti-tumor immune responses by blocking inhibitory signals mediated by SIGLEC10. ONC-841 restores the phagocytic and migratory activities of microglia, and promotes the phagocytosis of Amyloid-β and Tau protein aggregates by microglia. ONC-841 is applicable to research related to solid tumors and Alzheimer's disease .
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Cat. No.: HY-P990301

Target:  

Amyloid-β

Research Areas:  

Neurological Disease

Anti-Human/Mouse/Rat Amyloid-beta Antibody (MOAB-2) is a mouse-derived IgG2b λ type antibody inhibitor, targeting to Amyloid-beta. Anti-Human/Mouse/Rat Amyloid-beta Antibody (MOAB-2) recognizes unaggregated, oligomeric or fibrillar forms of Aβ42 and unaggregated Aβ40. Anti-Human/Mouse/Rat Amyloid-beta Antibody (MOAB-2) is selective for human Aβ42 over Aβ40, but not amyloid precursor protein (APP). Anti-Human/Mouse/Rat Amyloid-beta Antibody (MOAB-2) can immunostain human or rat and mouse tissue. Anti-Human/Mouse/Rat Amyloid-beta Antibody (MOAB-2) can be used for detections of western blot, immunohistochemistry, immunofluorescence, immunoprecipitation and ELISA .
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Cat. No.: HY-P990078
CAS No.: 2571940-41-3
Synonyms: LY3372993

Target:  

Amyloid-β

Research Areas:  

Neurological Disease

Remternetug (LY3372993) is a monoclonal antibody that targets pyroglutamylated amyloid β fibrils (N3pG-Aβ). Remternetug specifically binds to N3pG-Aβ, thereby clearing amyloid plaques in the brain and reducing amyloid burden. Remternetug can be used in research related to Alzheimer's disease .
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Cat. No.: HY-P990011
CAS No.: 2747959-38-0
Synonyms: ACU-193

Target:  

Amyloid-β

Research Areas:  

Neurological Disease

Sabirnetug is a humanized IgG2κ antibody targeting the Amyloid-β A4 precursor protein.
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Cat. No.: HY-P991130
CAS No.: 2991369-43-6

Target:  

Amyloid-β

Research Areas:  

Neurological Disease

Dalidnetug is a humanized monoclonal antibody targeting human amyloid-beta precursor protein (APP). Dalidnetug specifically binds to APP to reduce the production of amyloid-beta (Aβ), thus exerting the activity of clearing amyloid-beta. Dalidnetug is promising for research of Alzheimer's disease .
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Cat. No.: HY-P991702
CAS No.: 3024381-10-7

Target:  

Amyloid-β

Research Areas:  

Neurological Disease

Merinetug is a humanized IgG1κ antibody targeting Amyloid beta/Aβ. The corresponding isotype control is: Human IgG1 kappa, Isotype Control (HY-P99001) .
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Cat. No.: HY-P991168
CAS No.: 2988741-17-7
Velaprumig is a monoclonal antibody targeting human CD99, CCL25, and anti-human Aβ (Aβ-47F). Velaprumig regulates immune cell migration and reduces β-amyloid-related pathological processes, exerting immunomodulatory and potential anti - Alzheimer's disease activities .
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Cat. No.: HY-P1787
CAS No.: 477284-32-5
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

β-Amyloid (4-10) is an epitope for the polyclonal anti-Aβ(1-42) antibody, reduces amyloid deposition in a transgenic Alzheimer disease mouse model .
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Cat. No.: HY-P990081
CAS No.: 2669063-84-5
Synonyms: TB-006

Target:  

Inhibitory Antibodies

Research Areas:  

Neurological Disease

Oloctinebart is a humanized immunoglobulin G4-kappa, anti-LGALS3 monoclonal antibody. Oloctinebart is used for reduction of amyloid beta oligomers formation .
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Cat. No.: HY-P991535

Target:  

Amyloid-β

Research Areas:  

Neurological Disease

PMN310 is a monoclonal antibody targeting amyloid-β oligomers (AβO). PMN310 prevents AβO-induced memory loss and reduces synaptic loss and inflammation in vivo. PMN310 is potentially useful in Alzheimer's disease research .
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Cat. No.: HY-P991536

Target:  

Amyloid-β

Research Areas:  

Neurological Disease

KHK6640 is a humanized anti-amyloid beta oligomer-specific antibody. KHK6640 demonstrates high potency and efficacy for cognitive improvement in several rodent Alzheimer’s models. KHK6640 can be studied in research for neurological diseases such as Alzheimer’s disease .
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