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Results for "

Arrhythmia

" in MedChemExpress (MCE) Product Catalog:

253

Inhibitors & Agonists

2

Screening Libraries

2

Fluorescent Dye

3

Biochemical Assay Reagents

5

Peptides

29

Natural
Products

28

Isotope-Labeled Compounds

1

GMP Molecules

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-107754
    Cesium chloride

    		Potassium Channel Cardiovascular Disease
    Cesium chloride is a blocker of potassium channel. Cesium chloride prevents the decrease of Na + transport produced by Alloxan . Cesium chloride has induced cardiac arrhythmias, including torsade de pointes in animal models .
    Cesium chloride
  • HY-B0632
    Diltiazem
    5+ Cited Publications

    		 Calcium Channel Cardiovascular Disease Cancer
    Diltiazem is an orally active L-type Ca 2+ channel blocker. Diltiazem shows antihypertensive and antiarrhythmic effects. Diltiazem can be used for the research of cardiac arrhythmia, hypertension, and angina pectoris .
    Diltiazem
  • HY-14188
    Amiodarone hydrochloride
    10+ Cited Publications

    		 Potassium Channel Autophagy Cardiovascular Disease Infection Neurological Disease Cancer
    Amiodarone hydrochloride, a benzofuran-based Class III antiarrhythmic agent, inhibits WT outward ionic current (IhERG) tails with an IC50 of ∼45 nM . Amiodarone hydrochloride induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts . Amiodarone hydrochloride can be used in the research of both supraventricular and ventricular arrhythmias .
    Amiodarone hydrochloride
  • HY-B0432A
    Propafenone hydrochloride
    2 Publications Verification

    SA-79 hydrochloride

    		 Sodium Channel Cardiovascular Disease
    Propafenone (hydrochloride) (SA-79 (hydrochloride)) is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias.
    Propafenone hydrochloride
  • HY-17417A
    Naloxone
    5+ Cited Publications

    		 Opioid Receptor Neurological Disease Cancer
    Naloxone is an antagonist of Opioid receptor. Naloxone alleviates opioid-overdose-induced respiratory depression. Naloxone may cause pulmonary edema and cardiac arrhythmias .
    Naloxone
  • HY-A0154
    Deslanoside

    Deacetyllanatoside C; Desacetyllanatoside C

    		 Na+/K+ ATPase Drug Metabolite Cardiovascular Disease
    Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation. Deslanoside inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations .
    Deslanoside
  • HY-B1392
    Esmolol hydrochloride
    3 Publications Verification

    		 Adrenergic Receptor Caspase Apoptosis Aldose Reductase Neurokinin Receptor Cardiovascular Disease Endocrinology Cancer
    Esmolol hydrochloride is an ultra-short-acting cardioselective β1-adrenergic blocker. Esmolol hydrochloride exerts its antiarrhythmic effect by activating Neurokinin 1 Receptor. Esmolol hydrochloride attenuates post resuscitation myocardial dysfunction. Esmolol hydrochloride improves diabetic wound healing by inhibiting aldose reductase and the production of advanced glycation end products and promoting fibroblast migration. Esmolol hydrochloride can be used to study cardiac diseases such as arrhythmias and diabetic foot ulcers .
    Esmolol hydrochloride
  • HY-12533
    Disopyramide
    2 Publications Verification

    Dicorantil; SC-7031

    		 Sodium Channel Potassium Channel Cardiovascular Disease
    Disopyramide (Dicorantil) is a class IA antiarrhythmic agent with efficacy in ventricular and atrial arrhythmias. Disopyramide blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide inhibits HERG encoded potassium channels. Disopyramide also exhibits complex protein binding, and has a potent negative inotropic action .
    Disopyramide
  • HY-B0437
    Sotalol hydrochloride
    2 Publications Verification

    MJ 1999

    		 Adrenergic Receptor Potassium Channel Cardiovascular Disease Neurological Disease
    Sotalol hydrochloride (MJ 1999) is an orally active, non-selective β-adrenergic receptor blocker. Sotalol hydrochloride is a potent antiarrhythmic agent that can be used for the research of pediatric arrhythmias. Sotalol hydrochloride blocks β-receptors, and potassium KCNH2 channels. Antiepileptic Agent .
    Sotalol hydrochloride
  • HY-106225
    Rotigaptide
    1 Publications Verification

    ZP123

    		 Gap Junction Protein Cardiovascular Disease
    Rotigaptide (ZP123) is a novel and specific modulator of connexin 43 (Cx43). Rotigaptide prevents the uncoupling of Cx43-mediated gap junction communication and normalizes cell-to-cell communication during acute metabolic stress. Rotigaptide is a potent antiarrhythmic peptide (AAP) with improved stability and has the potential for the investigation of cardiac arrhythmias-specifically atrial fibrillation .
    Rotigaptide
  • HY-A0084A
    Procainamide
    5+ Cited Publications

    Procaine amide; SP 100

    		 DNA Methyltransferase Potassium Channel Cardiovascular Disease Cancer
    Procainamide (Procaine amide) is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1), which reactivates the expression of tumor suppressor factors by demethylating tumor suppressor genes. Procainamide induces vacuolization in various cell types and reduces cell proliferation and migration. Procainamide relaxes airway smooth muscle by activating potassium channels. Procainamide can be used in cancer and arrhythmia research .
    Procainamide
  • HY-A0084
    Procainamide hydrochloride
    5+ Cited Publications

    Procaine amide hydrochloride; SP 100 hydrochloride

    		 DNA Methyltransferase Potassium Channel Cancer
    Procainamide hydrochloride (Procaine amide hydrochloride) is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1), which reactivates the expression of tumor suppressor factors by demethylating tumor suppressor genes. Procainamide hydrochloride induces vacuolization in various cell types and reduces cell proliferation and migration. Procainamide hydrochloride relaxes airway smooth muscle by activating potassium channels. Procainamide hydrochloride can be used in cancer and arrhythmia research .
    Procainamide hydrochloride
  • HY-12533A
    Disopyramide phosphate
    2 Publications Verification

    Dicorantil phosphate; SC-7031 phosphate

    		 Potassium Channel Sodium Channel Cardiovascular Disease
    Disopyramide phosphate is a class IA antiarrhythmic agent with efficacy in ventricular and atrial arrhythmias. Disopyramide phosphate blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide phosphate inhibits HERG encoded potassium channels. Disopyramide phosphate also exhibits complex protein binding, and has a potent negative inotropic action .
    Disopyramide phosphate
  • HY-16738A
    Eleclazine hydrochloride
    2 Publications Verification

    GS 6615 hydrochloride

    		 Sodium Channel Potassium Channel Cardiovascular Disease
    Eleclazine (GS 6615) hydrochloride is a selective cardiac late sodium current inhibitor and a weak inhibitor of potassium current with IC50 value of <1 μM and approximately 14.2 μM, respectively. Eleclazine hydrochloride shows concurrent protection against autonomically induced atrial premature beats, repolarization alternans and heterogeneity, and atrial fibrillation in porcine model. Eleclazine hydrochloride can be used to research cardiac arrhythmias .
    Eleclazine hydrochloride
  • HY-B1238
    Pronethalol
    2 Publications Verification

    (±)-Pronethalo

    		 Adrenergic Receptor Cardiovascular Disease Neurological Disease
    Pronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias and limits the cerebral arteriovenous malformation (AVMs) .
    Pronethalol
  • HY-34350
    2-(Aminomethyl)phenol

    2-Hydroxybenzylamine; o-Hydroxybenzylamine; 2-HOBA

    		 Reactive Oxygen Species (ROS) Cardiovascular Disease Inflammation/Immunology
    2-(Aminomethyl)phenol (2-Hydroxybenzylamine) is a selective dicarbonyl scavenger. 2-(Aminomethyl)phenol is an antioxidant and scavanger of free radicals and isolevuglandins (IsoLGs). 2-(Aminomethyl)phenol can prevent early recurrence of atrial fibrillation. 2-(Aminomethyl)phenol can reduce inflammation and plaque apoptotic cells and promote efferocytosis and features of stable plaques. 2-(Aminomethyl)phenol can reduce malondialdehyde (MDA)-LDL and MDA-HDL levels in Ldlr -/- mouse model. 2-(Aminomethyl)phenol can be studied in the research of inflammation and cardiovascular disease, such as atherosclerosis, early recurrence of atrial fibrillation (AF) and arrhythmias .
    2-(Aminomethyl)phenol
  • HY-17497
    Acebutolol
    3 Publications Verification

    		 Adrenergic Receptor Cardiovascular Disease
    Acebutolol is an orally active β1 adrenergic receptor (β1AR) antagonist. Acebutolol is used for hypertension, angina pectoris and cardiac arrhythmias research .
    Acebutolol
  • HY-126028
    (-)-Sotalol

    (R)-Sotalol

    		 Potassium Channel Cardiovascular Disease
    (-)-Sotalol ((R)-Sotalol) is the R-isomer of Sotalol. (-)-Sotalol is a hERG inhibitor, with a Kd of 0.60 μM. (-)-Sotalol can be used for the research of cardiac arrhythmias .
    (-)-Sotalol
  • HY-N1924
    Crassicauline A

    Crassicaulin A

    		 Parasite Cardiovascular Disease Infection
    Crassicauline A (Crassicaulin A) is a diester-type diterpenoid alkaloid. Crassicauline A exhibits feeding deterrent activity against adult Tribolium castaneum, with a EC50 of 1134.5 ppm. Crassicauline A induces arrhythmia at a dose of 0.10 mg/kg .
    Crassicauline A
  • HY-130335
    Encainide

    MJ9067

    		 Sodium Channel Cardiovascular Disease
    Encainide (MJ9067) is an antiarrhythmic agent with class IC activity. Encainide blocks voltage-dependent potassium channels. Encainide has the potential for life-threatening ventricular arrhythmias, symptomatic ventricular arrhythmias and supraventricular arrhythmias research .
    Encainide
  • HY-119802
    Practolol

    		Adrenergic Receptor Cardiovascular Disease
    Practolol is a potent and selective β1-adrenergic receptor antagonist. Practolol can be used for the research of cardiac arrhythmias .
    Practolol
  • HY-103059
    SOICR-IN-1

    		Calcium Channel Cardiovascular Disease
    SOICR-IN-1 (compound 32) is a store-overload induced calcium release (SOICR) inhibitor with an IC50 value of 14.6 μM. SOICR-IN-1 can be used for the research of cardiac arrhythmias .
    SOICR-IN-1
  • HY-126486
    AVE1231

    A293

    		 Potassium Channel Cardiovascular Disease
    AVE1231 (A293) is a dual-pore potassium channel TASK-1 inhibitor. AVE1231 blocks carbamoylcholine chloride (HY-B1208)-activated IKACh (IC50=8.4 μM). AVE1231 can be used in the study of arrhythmias and atrial fibrillation .
    AVE1231
  • HY-W802239
    Asparaginate calcium

    		Drug Derivative Cardiovascular Disease Metabolic Disease
    Asparaginate calcium is a calcium 2+ salt of asparaginate and anion/zwitterion form of aspartic acid. Asparaginate calcium is a calcium supplement and an antiarrhythmic active substance. Asparaginate calcium can be used for the research of arrhythmia .
    Asparaginate calcium
  • HY-111013
    VK-II-86

    		Drug Derivative Adrenergic Receptor Cardiovascular Disease
    VK-II-86 is a Carvedilol (HY-B0006) analogue lacking antagonist activity at β-adrenoceptors, in hypokalaemia. VK-II-86 prevents hypokalaemia-induced ventricular arrhythmia through multi-channel effects. VK-II-86 prevents all hypokalaemia-induced changes in ion channel activity and oxidative stress .
    VK-II-86
  • HY-15208
    Clamikalant sodium

    HMR 1098

    		 Potassium Channel Neurological Disease
    Clamikalant sodium (HMR 1098) is an ATP-sensitive potassium (KATP) channel blocker. Clamikalant sodium can be used for the research of arrhythmia .
    Clamikalant sodium
  • HY-119747
    WAY-123223

    		Potassium Channel Cardiovascular Disease
    WAY-123223 is an orally active potassium channel (Potassium Channel) blocker. WAY-123223 prolongs the transmembrane action potential duration and cardiac refractory period of canine Purkinje fibers. In canine models, WAY-123223 increases the ventricular fibrillation threshold, restores sinus rhythm from ventricular fibrillation, and exerts antiarrhythmic effects. WAY-123223 can be used in research related to cardiovascular diseases such as arrhythmias .
    WAY-123223
  • HY-120774
    GS-462808

    		Sodium Channel Cardiovascular Disease
    GS-462808 is an oral active late sodium current inhibitor (Late INai) of the cardiac Nav1.5 channel with the IC50 of 1.33 μM. GS-462808 can be used for study of arrhythmia .
    GS-462808
  • HY-130368
    W-7
    5+ Cited Publications

    		 Calmodulin Potassium Channel Phosphodiesterase (PDE) Myosin Apoptosis Cardiovascular Disease
    W-7 is a selective calmodulin antagonist. W-7 inhibits the Ca 2+-calmodulin-dependent phosphodiesterase and myosin light chain kinase with IC50 values of 28 μM and 51 μM, respectively. W-7 induces apoptosis and has antitumor and vascular relaxing activity. W-7 is a blocker of Kv4.3 and can be used for research of arrhythmias .
    W-7
  • HY-N3198A
    Sophoramine
    1 Publications Verification

    (-)-Sophoramine

    		 Adrenergic Receptor Cardiovascular Disease
    Sophoramine ((-)-Sophoramine) is a prejunctional α2-adrenoceptor inhibitor that can be found in the seeds of Sophora alopecuroides. Sophoramine inhibits prejunctional α2-adrenoceptors to facilitate norepinephrine release from adrenergic nerves. Sophoramine shows cytotoxic activity against human cancer cells, positive inotropic activity, and activity in rodent arrhythmia models. Sophoramine can be used for the research of arrhythmias .
    Sophoramine
  • HY-W492795
    Quifenadine hydrochloride

    		Histamine Receptor Cardiovascular Disease
    Quifenadine hydrochloride is an H1-histamine receptor blocker and can be used in the research of anti-arrhythmia .
    Quifenadine hydrochloride
  • HY-106895
    L-702958

    		Potassium Channel Cardiovascular Disease
    L-702958 is a potent hERG blocker (IC50 = 14.3 nM). L-702958 can be used for research on arrhythmia .
    L-702958
  • HY-B0432AS4
    Propafenone-(phenyl-d5) hydrochloride

    		Sodium Channel Cardiovascular Disease
    Propafenone-(phenyl-dd5) (hydrochloride) is the deuterium labeled Propafenone hydrochloride[1]. Propafenone hydrochloride is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias[2].
    Propafenone-(phenyl-d5) hydrochloride
  • HY-106718
    Barucainide

    		Sodium Channel Cardiovascular Disease
    Barucainide is an Ib-class anti-arrhythmic agent (moderately blocking sodium channel). Barucainide exhibits concentration-dependent inhibitory effects on the maximum upstroke velocity (Vmax) of Purkinje fibers and ventricular muscle in dogs. Barucainide significantly shortens the action potential duration (APD). Barucainide significantly inhibits the pacemaker activity frequency of atrial tissue in rabbits and the enhanced automaticity of Purkinje fibers under normal resting potential in response to isoproterenol. Barucainide cannot inhibit the abnormal automaticity emission frequency of canine Purkinje fibers induced by barium. Barucainide can be used for research on arrhythmias .
    Barucainide
  • HY-122149
    L-648051

    		Leukotriene Receptor Cardiovascular Disease
    L-648051 is a leukotriene D4 receptor (LTD4) antagonist. L-648051 plays an important role in arrhythmias .
    L-648051
  • HY-120141
    L-768673

    		Potassium Channel Cardiovascular Disease
    L-768673 is a potent selective IKs blocker with antiarrhythmic effects. L-768673 plays important roles in both atrial and ventricular refractoriness as well as pacemaker function in the dog heart. L-768673 can be used for arrhythmias research .
    L-768673
  • HY-177361
    Zocainone

    		Sodium Channel Cardiovascular Disease
    Zocainone is an antiarrhythmic agent. Zocainone blocks sodium channels in cardiac tissue, stabilizing the cardiac action potential and reducing abnormal electrical activity. Zocainone is promising for research of cardiac arrhythmias .
    Zocainone
  • HY-103196
    Sotalol

    		Adrenergic Receptor Potassium Channel Cardiovascular Disease Neurological Disease
    Sotalol is an orally active, non-selective β-adrenergic receptor blocker. Sotalol is a potent antiarrhythmic agent that can be used for the research of pediatric arrhythmias. Sotalol blocks β-receptors, and potassium KCNH2 channels. Antiepileptic Agent .
    Sotalol
  • HY-B1392A
    Esmolol

    		Adrenergic Receptor Caspase Apoptosis Aldose Reductase Neurokinin Receptor Cardiovascular Disease Endocrinology Cancer
    Esmolol is an ultra-short-acting cardioselective β1-adrenergic blocker. Esmolol exerts its antiarrhythmic effect by activating Neurokinin 1 Receptor. Esmolol attenuates post resuscitation myocardial dysfunction. Esmolol improves diabetic wound healing by inhibiting aldose reductase and the production of advanced glycation end products and promoting fibroblast migration. Esmolol can be used to study cardiac diseases such as arrhythmias and diabetic foot ulcers .
    Esmolol
  • HY-106225R
    Rotigaptide (Standard)

    ZP123 (Standard)

    		 Reference Standards Gap Junction Protein Cardiovascular Disease
    Rotigaptide (Standard) is the analytical standard of Rotigaptide. This product is intended for research and analytical applications. Rotigaptide (ZP123) is a novel and specific modulator of connexin 43 (Cx43). Rotigaptide prevents the uncoupling of Cx43-mediated gap junction communication and normalizes cell-to-cell communication during acute metabolic stress. Rotigaptide is a potent antiarrhythmic peptide (AAP) with improved stability and has the potential for the investigation of cardiac arrhythmias-specifically?atrial fibrillation .
    Rotigaptide (Standard)
  • HY-100952
    Nifenalol hydrochloride

    		Adrenergic Receptor Cardiovascular Disease
    Nifenalol hydrochloride is a β-adrenergic receptor antagonist. Nifenalol hydrochloride induces the Early Afterdepolarization (EAD) effect. EAD is a phenomenon in cardiac electrophysiology that usually occurs during an action potential in ventricular muscle cells and can lead to arrhythmia. The EAD effect of Nifenalol hydrochloride can be blocked by Tetrodotoxin. Nifenalol hydrochloride is used in the study of conditions such as irregular heartbeat or high blood pressure .
    Nifenalol hydrochloride
  • HY-B0432AS2
    Propafenone-d5 hydrochloride

    		Isotope-Labeled Compounds Sodium Channel Cardiovascular Disease
    Propafenone-d5 (hydrochloride) is the deuterium labeled Propafenone hydrochloride. Propafenone (SA-79) hydrochloride is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias[1].
    Propafenone-d5 hydrochloride
  • HY-113322
    3-Hydroxyquinine

    3-Hydroxyquinidine

    		 Drug Metabolite Cardiovascular Disease
    3-Hydroxyquinine is a metabolite of Quinidine (HY-B1751). 3-Hydroxyquinine prevents ventricular fibrillation and ventricular tachycardia after coronary reperfusion in an isolated rat heart reperfusion arrhythmia model in a concentration-dependent manner. 3-Hydroxyquinine can be used in the study of cardiac arrhythmias .
    3-Hydroxyquinine
  • HY-101390D
    (R)-Niguldipine

    		Calcium Channel Cardiovascular Disease
    (R)-Niguldipine, a R-epimer of Niguldipine (HY-101390B), is a calcium channel antagonist. (R)-Niguldipine exerts a vasodilatory effect by blocking calcium channels and reducing the transmembrane influx of calcium ions. (R)-Niguldipine can inhibit U-46619 (HY-108566)-induced coronary artery contraction in guinea pig Langendorff hearts (pID50 of 9.93), has high affinity for calcium channel binding sites on guinea pig skeletal muscle membranes (Ki of 8.10), and lowers blood pressure in spontaneously hypertensive rats (pED30 of 5.55). (R)-Niguldipine can improve cardiovascular diseases such as hypertension, angina pectoris, and arrhythmias .
    (R)-Niguldipine
  • HY-12531
    Encainide hydrochloride

    MJ9067 hydrochloride

    		 Sodium Channel Cardiovascular Disease
    Encainide (MJ9067) hydrochloride is an antiarrhythmic agent with class IC activity. Encainide hydrochloride blocks voltage-dependent potassium channels. Encainide hydrochloride has the potential for life-threatening ventricular arrhythmias, symptomatic ventricular arrhythmias and supraventricular arrhythmias research .
    Encainide hydrochloride
  • HY-118172
    PD-307243

    		Potassium Channel Cardiovascular Disease
    PD-307243 is a hERG channel activator. PD-307243 can be used for research of arrhythmias .
    PD-307243
  • HY-123646
    RS 2135

    		Others Cardiovascular Disease
    RS 2135 is an antiarrhythmic compound that can suppress ischemia-induced ventricular arrhythmias .
    RS 2135
  • HY-106895A
    L-702958 hydrochloride

    		Potassium Channel Cardiovascular Disease
    L-702958 hydrochloride is a potent hERG blocker (IC50 = 14.3 nM). L-702958 hydrochloride can be used for research on arrhythmia .
    L-702958 hydrochloride
  • HY-113858
    Brefonalol

    		Adrenergic Receptor Cardiovascular Disease
    Brefonalol is a beta-adrenergic receptor blocker. Brefonalol can be used for the research of hypertension, arrhythmias and angina pectoris .
    Brefonalol
  • HY-171782
    Amidepin

    		Others Cardiovascular Disease
    Amidepin is a new type of antiarrhythmic compound. Amidepin has the activity of regulating cardiac electrical activity. The main regulatory mechanism of amidepin involves ion channel or receptor interaction. Amidepin can be used for the study of arrhythmias .
    Amidepin

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