42399-41-7
42399-41-7
Chemical Structure
Diltiazem
- CAS No.: 42399-41-7
- Formula:C22H26N2O4S
- Molecular Weight:414.52
IUPAC Name: (2S,3S)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate
InChIKey: HSUGRBWQSSZJOP-RTWAWAEBSA-N
SMILES: CN(C)CCN1C2=CC=CC=C2S[C@@H](C3=CC=C(OC)C=C3)[C@@H](OC(C)=O)C1=O
Biological Activity: Diltiazem is a calcium antagonist and an L-type calcium channel inhibitor. Diltiazem inhibits Ca2+ mobilization/influx, norepinephrine-induced contraction, and depolarization. Diltiazem produces coronary vasodilation and renal vasodilation; it inhibits sodium reabsorption in the distal nephron and increases urine flow, sodium and potassium excretion, Inulin (HY-N7075) and PAH clearance, and free water clearance. Diltiazem is used in research on cardiovascular diseases, kidney diseases, and inflammation[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Diltiazem | 99.70% | Diltiazem is a calcium antagonist and an L-type calcium channel inhibitor. Diltiazem inhibits Ca2+ mobilization/influx, norepinephrine-induced contraction, and depolarization. Diltiazem produces coronary vasodilation and renal vasodilation; it inhibits sodium reabsorption in the distal nephron and increases urine flow, sodium and potassium excretion, Inulin (HY-N7075) and PAH clearance, and free water clearance. Diltiazem is used in research on cardiovascular diseases, kidney diseases, and inflammation. | ||||||||||||||||||||
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Diltiazem (Standard) | ≥98% | Diltiazem (Standard) is the analytical standard of Diltiazem (HY-B0632). This product is intended for research and analytical applications. Diltiazem is a calcium antagonist and an L-type calcium channel inhibitor. Diltiazem inhibits Ca2+ mobilization/influx, norepinephrine-induced contraction, and depolarization. Diltiazem produces coronary vasodilation and renal vasodilation; it inhibits sodium reabsorption in the distal nephron and increases urine flow, sodium and potassium excretion, Inulin (HY-N7075) and PAH clearance, and free water clearance. Diltiazem is used in research on cardiovascular diseases, kidney diseases, and inflammation. | ||||||||||||||||||||
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Diltiazem-d3 hydrochloride | 98.70% | Diltiazem-d3 hydrochloride (CRD-401-d3) is the deuterated-labeled Diltiazem (HY-B0632). Diltiazem is a calcium antagonist and an L-type calcium channel inhibitor. Diltiazem inhibits Ca2+ mobilization/influx, norepinephrine-induced contraction, and depolarization. Diltiazem produces coronary vasodilation and renal vasodilation; it inhibits sodium reabsorption in the distal nephron and increases urine flow, sodium and potassium excretion, Inulin (HY-N7075) and PAH clearance, and free water clearance. Diltiazem is used in research on cardiovascular diseases, kidney diseases, and inflammation. | ||||||||||||||||||||
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Diltiazem-d4 | Diltiazem-d4 is the deuterated-labeled Diltiazem (HY-B0632). Diltiazem is a calcium antagonist and an L-type calcium channel inhibitor. Diltiazem inhibits Ca2+ mobilization/influx, norepinephrine-induced contraction, and depolarization. Diltiazem produces coronary vasodilation and renal vasodilation; it inhibits sodium reabsorption in the distal nephron and increases urine flow, sodium and potassium excretion, Inulin (HY-N7075) and PAH clearance, and free water clearance. Diltiazem is used in research on cardiovascular diseases, kidney diseases, and inflammation. | |||||||||||||||||||||
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Diltiazem-d6 | Diltiazem-d6 is the deuterated-labeled Diltiazem (HY-B0632). Diltiazem is a calcium antagonist and an L-type calcium channel inhibitor. Diltiazem inhibits Ca2+ mobilization/influx, norepinephrine-induced contraction, and depolarization. Diltiazem produces coronary vasodilation and renal vasodilation; it inhibits sodium reabsorption in the distal nephron and increases urine flow, sodium and potassium excretion, Inulin (HY-N7075) and PAH clearance, and free water clearance. Diltiazem is used in research on cardiovascular diseases, kidney diseases, and inflammation. | |||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.98
HY-14656RDiltiazem hydrochloride (Standard) -
Similarity Score 0.98
HY-B0632B(2R,3R)-Diltiazem hydrochloride -
Similarity Score 0.89
HY-183138N-Demethyldiltiazem -
Similarity Score 0.89
HY-Z8033N-Desmethyl diltiazem hydrochloride -
Similarity Score 0.88
HY-14656S1Diltiazem-(acetoxy-d3) hydrochloride -
Similarity Score 0.86
HY-B0632ADiltiazem malate -
Similarity Score 0.83
HY-14656S2Diltiazem-d6 hydrochloride -
Similarity Score 0.81
HY-126182Deacetyldiltiazem -
Explore the MedChemAI to find more analogs
References
- [1]. Nagao T, et al. Studies on a New 1,5-Benzothiazepine Derivative (CRD-401). IV. Coronary Vasodilating Effect and Structure-Activity Relationship. Chemical and Pharmaceutical Bulletin, 1973, 21(1): 92-97.
- [2]. Yamaguchi I, et al. Studies on a New 1,5-Benzothiazepine Derivative (CRD-401): VI. Effects on Renal Blood Flow and Renal Function. Japanese Journal of Pharmacology, 1974, 24(4): 511-522.
- [3]. Ito Y, et al. The effects of diltiazem (CRD-401) on the membrane and mechanical properties of vascular smooth muscles of the rabbit. British journal of pharmacology. 1978 Dec;64(4):503-10. [Content Brief]
- [4]. Mieth A, et al. L-type calcium channel inhibitor diltiazem prevents aneurysm formation by blood pressure-independent anti-inflammatory effects. Hypertension. 2013 Dec;62(6):1098-104. [Content Brief]
