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Results for "

Autophagy-IN-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (1) Androgen Receptor (2) Antibiotic (3) Apoptosis (5) Atg4 (2) Atg8/LC3 (1) AUTACs (1) Autophagy (23) Bcl-2 Family (1) Caspase (1) Cathepsin (2) CDK (1) CHIKV (1) Cytochrome P450 (3) Dengue Virus (2) Drug Derivative (1) Flavivirus (2) Fluorescent Dye (1) Fungal (4) Glutathione S-transferase (1) HDAC (1) HIV (2) HSP (2) mTOR (2) Phospholipase (1) PI3K (1) Pim (1) PINK1/Parkin (1) Reference Standards (3) TRP Channel (2) ULK (1)
By Research Areas:	Cancer (21) Infection (8) Inflammation/Immunology (2) Metabolic Disease (3) Neurological Disease (3)

By Targets:

AMPK (1)

Androgen Receptor (2)

Antibiotic (3)

Apoptosis (5)

Atg4 (2)

Atg8/LC3 (1)

AUTACs (1)

Autophagy (23)

Bcl-2 Family (1)

Caspase (1)

Cathepsin (2)

CDK (1)

CHIKV (1)

Cytochrome P450 (3)

Dengue Virus (2)

Drug Derivative (1)

Flavivirus (2)

Fluorescent Dye (1)

Fungal (4)

Glutathione S-transferase (1)

HDAC (1)

HIV (2)

HSP (2)

mTOR (2)

Phospholipase (1)

PI3K (1)

Pim (1)

PINK1/Parkin (1)

Reference Standards (3)

TRP Channel (2)

ULK (1)

By Research Areas:

Cancer (21)

Infection (8)

Inflammation/Immunology (2)

Metabolic Disease (3)

Neurological Disease (3)

Inhibitors & Agonists

Fluorescent Dyes

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-70002

Enzalutamide Maximum Cited Publications 214 Publications Verification MDV3100	Androgen Receptor Autophagy	Cancer
Enzalutamide (MDV3100) is an androgen receptor (AR) antagonist with an IC₅₀ of 36 nM in LNCaP prostate cells. Enzalutamide is an *autophagy* activator .

HY-108462

ML-SA1 5+ Cited Publications	Dengue Virus TRP Channel Flavivirus	Infection
ML-SA1, as a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC₅₀ value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively. ML-SA1 induces *autophagy*. ML-SA1 can be used for the research of broad-spectrum antiviral ^[1].

HY-P2260

Tat-beclin 1 5+ Cited Publications	CHIKV Autophagy HIV	Infection
Tat-beclin 1, a peptide derived from a region of the autophagy protein (beclin 1), is a potent inducer of *autophagy* and interacts with negative regulator of autophagy, GAPR-1 (GLIPR2). Tat-beclin 1 decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens (including *HIV-1*) in vitro, and reduces mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV) ^[1].

HY-70002R

Enzalutamide (Standard) MDV3100 (Standard)	Reference Standards Androgen Receptor Autophagy	Cancer
Enzalutamide (Standard) is the analytical standard of Enzalutamide. This product is intended for research and analytical applications. Enzalutamide (MDV3100) is an androgen receptor (AR) antagonist with an IC₅₀ of 36 nM in LNCaP prostate cells. Enzalutamide is an *autophagy* activator .

HY-135318

NBDHEX 2 Publications Verification	Apoptosis Autophagy Glutathione S-transferase	Cancer
NBDHEX is a potent glutathione S-transferase P1-1 (GSTP1-1) inhibitor. NBDHEX induces apoptosis of tumor cells. NBDHEX acts as an anticancer agent by inhibiting GSTs catalytic activity, avoiding inconvenience of the inhibitor extrusion from the cell by specific pumps and disrupting the interaction between the *GSTP1-1* and key signaling effectors. NBDHEX can also act as late-phase *autophagy* inhibitor .

HY-B1324

Oxiconazole nitrate 2 Publications Verification Ro 13-8996	Fungal Cytochrome P450 Antibiotic	Infection Cancer
Oxiconazole (Ro 13-8996) nitrate is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole nitrate is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole nitrate exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated *autophagy* arrest .

HY-129652

HaloAUTAC tt15	AUTACs	Cancer
HaloAUTAC tt15 is an autophagy-targeting chimera (AUTAC), that targets the Halo Tag carrying proteins, and degrades via the autophagy mechanism .

HY-150636

*Autophagy-IN-1*	Autophagy Apoptosis	Cancer
Autophagy-IN-1 is a potent *autophagy/mitophagy* inhibitor, acts by selectively increasing the autophagic flux while blocking the autophagosome-lysosome fusion in cancer cells. Autophagy-IN-1 can induce apoptosis and cell cycle arrest. Autophagy-IN-1 significantly inhibits tumor growth in an HCT116 xenograft mouse model and with low toxicity. Autophagy-IN-1 can be used for researching colorectal cancer ^[1].

HY-N8678

Thonningianin B	Autophagy	Neurological Disease
Thonningianin B is an antioxidant and an *autophagy* enhancer .

HY-112818

S130	Atg4 Cathepsin Autophagy Apoptosis	Cancer
S130 is a high affinity, selective inhibitor of ATG4B (a major cysteine protease) with an IC₅₀ of 3.24 µM. S130 suppresses autophagy flux .

HY-144636

Atg4B-IN-2	Atg4 Cathepsin Phospholipase Autophagy	Cancer
Atg4B-IN-2 is a potent competitive Atg4B inhibitor with K_i value of 3.1 μM, also possesses declining PLA₂ inhibitory potency, IC₅₀s of 11 μM and 3.5 μM for Atg4B and PLA₂, respectively. Atg4B-IN-2 enhances the anticancer activity of anti-castration-resistant prostate cancer agents via *autophagy* inhibition .

HY-162006

Pim-1 kinase inhibitor 8	Pim Apoptosis Autophagy	Metabolic Disease Inflammation/Immunology Cancer
Pim-1 kinase inhibitor 8 is a potent *PIM-1* inhibitor with an IC₅₀ value of 14.3 nM. Pim-1 kinase inhibitor 8 impedes cell proliferation and migration through PIM-1 inhibition and the induction of both apoptosis and *autophagy*. Pim-1 kinase inhibitor 8 inhibits solid tumor growth in Solid Ehrlich Carcinoma (SEC)-bearing mice. Pim-1 kinase inhibitor 8 can be used for breast and liver cancer research ^[1].

HY-170992

*Autophagy agonist-1*	Autophagy CDK Atg8/LC3 PINK1/Parkin	Cancer
Autophagy agonist-1 (compound 22) is an *Autophagy* agonist. Autophagy agonist-1 exhibits significant anticancer activity against HepG2 cells and normal cells with IC₅₀s of 8.8 μM and > 50 μM. Autophagy agonist-1 induces G1/S phase cell cycle arrest and inhibits CDK4 and CyclinD1 expression while upregulating P21. Autophagy agonist-1 promotes the accumulation of autophagosomes and the proteins LC3 and *PINK1, enhancing autophagy* and mitophagy in HepG2 cells ^[1].

HY-147039

BOLD-100 free base NKP-1339 free base; IT-139 free base; KP-1339 free base	HSP Autophagy	Cancer
BOLD-100 (NKP-1339; IT-139) free base is a ruthenium-based anticancer agent. BOLD-100 free base also is an inhibitor of stress-induced GRP78 upregulation, disrupting endoplasmic reticulum (ER) homeostasis and inducing ER stress and unfolded protein response (UPR). BOLD-100 free base interferes with the complex interplay between ER-stress response, lysosome dynamics, and *autophagy* execution .

HY-178192

mTORC1-IN-3	mTOR Autophagy	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
mTORC1-IN-3 is a potent and selective *mTORC1* inhibitor with an IC₅₀ of 26.38 μM . mTORC1-IN-3 selectively inhibits the phosphorylation of mTORC1 substrates and does not without affect the phosphorylation of mTORC2 substrate. mTORC1-IN-3 can reduce cellular lipid accumulation and induce *autophagy*. mTORC1-IN-3 can be used for the researches of cancer, immunology, metabolic and neurological disease, such as diabetes and Alzheimer’s disease ^[1].

HY-170667

*Autophagy activator-1*	Autophagy HSP	Cancer
Autophagy activator-1 (Compound B2) is an *autophagy* activator Autophagy. Activator-1 ultimately leads to the activation of *autophagy* by downregulating key members of the HSP70 family and activating the unfolded protein response ^[1].

HY-174157

AR493	Autophagy AMPK	Neurological Disease Metabolic Disease
AR493 is an *autophagy* activator acting on AMPK (adenosine monophosphate-activated protein kinase). AR493 regulates pathways related to cellular energy sensing and increases autophagy levels. AR493 is promising for research of aging-associated diseases (such as diabetes, neurodegenerative diseases) and autophagy regulation .

HY-P2260A

Tat-beclin 1 TFA	Autophagy HIV	Infection
Tat-beclin 1 TFA, a peptide derived from a region of the autophagy protein (beclin 1), is a potent inducer of *autophagy* and interacts with negative regulator of autophagy, GAPR-1 (GLIPR2). Tat-beclin 1 TFA decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens (including *HIV-1*) in vitro, and reduces mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV) ^[1].

HY-B1324A

Oxiconazole Ro 13-8996 free base	Fungal Cytochrome P450 Antibiotic	Infection Cancer
Oxiconazole (Ro 13-8996) is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated *autophagy* arrest .

HY-154910

CC214-1	mTOR	Cancer
CC214-1 is a potentially efficacious mTOR inhibitor that induces *autophagy* ,with an IC₅₀ is 0.002 μM. CC214-1 proved to be useful as an in vitro tool compound for the exploration of mTOR kinase biology. CC214-1 can be used for Glioblastoma study .

HY-P10711

ALA-A2 peptide	Autophagy	Cancer
ALA-A2 is an anticancer peptide discovered in alpha-lactalbumin that selectively kills cancer cells by inducing *Autophagy. ALA-A2 has cell-penetrating capabilities, allowing it to effectively enter cells without relying on membranolytic effects. In A549 lung cancer cells, ALA-A2 demonstrates significant dose-dependent anticancer activity. ALA-A2 holds promise for research in cancer therapy and autophagy regulation .*

HY-168477

HDAC1-IN-8	HDAC Autophagy	Cancer
HDAC1-IN-8 (compound 5c) is a potent and selective *HDAC1* inhibitor with IC₅₀ values of 11.94, 22.95, >500 µM for HDAC1, HDAC6, HDAC8, respectively. HDAC1-IN-8 shows antiproliferative activity. HDAC1-IN-8 induces cell cycle arrest at G1 and G2/M. HDAC1-IN-8 induces *autophagy*. HDAC1-IN-8 shows anticancer activity and has the potential for the research of lung cancer ^[1].

HY-B1324R

Oxiconazole nitrate (Standard) Ro 13-8996 (Standard)	Reference Standards Fungal Cytochrome P450 Antibiotic	Infection Cancer
Oxiconazole nitrate (Standard) is the analytical standard of Oxiconazole nitrate. This product is intended for research and analytical applications. Oxiconazole (Ro 13-8996) nitrate is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole nitrate is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole nitrate exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest .

HY-183732

ATG5 PPI-IN-2	Autophagy	Others
ATG5 PPI-IN-2 (Compound 12f) is a selective inhibitor of ATG5-TECAIR protein-protein interaction, with a IC₅₀ of 19.16 μM. ATG5 PPI-IN-2 also acts as an *Autophagy* inhibitor .

HY-D2977

AF-1	Fluorescent Dye Autophagy Fungal	Infection
AF-1 is a azole-based near-infrared fluorescence diagnostic probe with an emission wavelength of 632 nm. AF-1 selectively accumulates in fungal cell membranes at physiological pH. AF-1 targets and induces *Autophagy*. AF-1 exhibits antifungal activity and sensitivity to autophagy-related pH ^[1].

HY-181742

ULK1/2-IN-1	ULK PI3K Autophagy	Cancer
ULK1/2-IN-1 is a tissue-targeted *ULK1/2* inhibitor conjugated to the RGR (CRGRRST) tumor neovasculature-homing peptide. ULK1/2-IN-1 mediates *autophagy* inhibition and induces cytotoxicity in endothelial cells. ULK1/2-IN-1 can be used for the research of tumor-targeted autophagy inhibitors .

HY-183807

T1742	Autophagy	Cancer
T1742 is an *autophagy* inhibitor targeting ATG5. T1742 blocks and disrupts protein-protein interactions between ATG5 and *ATG16L1, and between ATG5* and TECAIR.T 1742 inhibits autophagy in living cells via reduced autophagosome formation and downregulated ATG8-PE conjugation. T1742 can be used to study autophagy mechanisms .

HY-183730

4E1RCat 17d	Autophagy Drug Derivative	Others
4E1RCat 17d (Compound 17d) is a derivative of the ATG5 inhibitor lead compound T1742. 4E1RCat 17d shows no activity against the interactions of *ATG5-ATG16L1* and ATG5-TECAIR. 4E1RCat 17d induces *Autophagy* inhibition .

HY-108462R

ML-SA1 (Standard)	Dengue Virus Reference Standards TRP Channel Flavivirus	Infection
ML-SA1 (Standard) is the analytical standard of ML-SA1 (HY-108462). This product is intended for research and analytical applications. ML-SA1, as a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC₅₀ value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral ^[1].

HY-183772

TBC1D2-IN-1	Autophagy Apoptosis Caspase Bcl-2 Family	Cancer
TBC1D2-IN-1 is a potent orally active and selective *TBC1D2* inhibitor with a K_d of 1.1 μM. TBC1D2-IN-1 selectively inhibits *TBC1D2*-mediated GTP hydrolysis on RAB7A-GTP, promotes RAB7A accumulation on lysosomal membranes, and induces apoptosis and *autophagy*. TBC1D2-IN-1 exerts selective antiproliferative activity cancer cells. TBC1D2-IN-1 can be used for the research of cervical carcinoma ^[1].

AF-1	Fluorescent Dyes
AF-1 is a azole-based near-infrared fluorescence diagnostic probe with an emission wavelength of 632 nm. AF-1 selectively accumulates in fungal cell membranes at physiological pH. AF-1 targets and induces *Autophagy*. AF-1 exhibits antifungal activity and sensitivity to autophagy-related pH ^[1].

Cat. No.	Product Name	Target	Research Area