530 Results for "

COX activity

" in MedChemExpress (MCE) Product Catalog:
Products (530)

530 Results for "COX activity" in MCE Product Catalog:

  • Targets Recommended:
83
Indomethacin
Indomethacin
0 Images
83 Publications Verification
Cat. No.: HY-14397
CAS No.: 53-86-1
Purity:  99.91%
Synonyms: Indometacin
Target:  

COX Antibiotic Influenza Virus Bacterial

Research Areas:  

Infection Neurological Disease Inflammation/Immunology Cancer

Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research .
loading...
    loading...
View All Sizes
83
Indomethacin sodium hydrate
Indomethacin sodium hydrate
0 Images
83 Publications Verification
Cat. No.: HY-14397A
CAS No.: 74252-25-8
Purity:  99.85%
Synonyms: Indometacin sodium hydrate
Target:  

COX Bacterial Influenza Virus Antibiotic

Research Areas:  

Infection Neurological Disease Inflammation/Immunology Cancer

Indomethacin (Indometacin) sodium hydrateis a orally active and BBB-permeable COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin sodium hydrateis has anticancer activity and anti-infective activity. Indomethacin sodium hydrateis can be used for cancer, inflammation and viral infection research .
loading...
    loading...
View All Sizes
64
Leupeptin hemisulfate
Leupeptin hemisulfate
0 Images
64 Cited Publications
Cat. No.: HY-18234A
CAS No.: 103476-89-7
Category:  

Natural Products Microorganisms Disease Research Fields Inflammation/Immunology

Target:  

Ser/Thr Protease Cathepsin Autophagy SARS-CoV Atg8/LC3 NO Synthase COX p62 Arginase PTEN NF-κB PI3K Akt p38 MAPK ERK Reactive Oxygen Species (ROS)

Leupeptin hemisulfate is a broad-spectrum protease inhibitor. Leupeptin hemisulfate inhibits serine, cysteine and threonine proteases, and regulates autophagy. Leupeptin hemisulfate reduces the expression levels of LC3B, iNOS, Cox-2, Beclin-1 and the level of endopeptidases; increases the levels of p62, Arg 1, Msr 1 and Mrc −1; and blocks the upregulation of p-PTEN, p-NF-κB, p-PI3K, p-Akt, p-p38 and ERK1/2. Leupeptin hemisulfate inhibits NO, ROS, proinflammatory cytokines, the IFN-γ/IL-10 ratio, phagolysosome fusion, mammalian lysosomal hydrolase activity and SARS-CoV-2 replication; and reverses impaired autophagic flux. Leupeptin hemisulfate is applicable to research related to chronic inflammatory diseases, edema, skin tumorigenesis, COVID-19 and respiratory infections .
loading...
    loading...
View All Sizes
21
NS-398
NS-398
0 Images
21 Cited Publications
Cat. No.: HY-13913
CAS No.: 123653-11-2
Purity:  99.71%
Target:  

COX

Research Areas:  

Inflammation/Immunology Cancer

NS-398 is a non-steroidal an-inflammatory agent with analgesic and antipyretic effects, and selectively inhibits prostaglandin G/H synthase 2/cyclooxygenase 2 (COX-2) activity, with an IC50 of 3.8 μM, and has no effect on COX-1 at 100 μM.
loading...
    loading...
View All Sizes
19
Cardamonin
Cardamonin
0 Images
19 Cited Publications
Cat. No.: HY-N0279
CAS No.: 18956-16-6
Synonyms: Cardamomin; Alpinetin chalcone
Category:  

Flavonoids Chalcones Boesenbergia rotunda  Phenols Polyphenols Plants Disease Research Fields Cancer Zingiberaceae

Target:  

NF-κB STAT Wnt β-catenin Bcl-2 Family Apoptosis

Cardamonin can be found from cardamom, and can target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit mTOR, NF-κB, Akt, STAT3, Wnt/β-catenin and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities .
loading...
    loading...
View All Sizes
18
Gallic acid
Gallic acid
0 Images
18 Cited Publications
Cat. No.: HY-N0523
CAS No.: 149-91-7
Synonyms: 3,4,5-Trihydroxybenzoic acid
Category:  

Anti-aging Metabolic Disease Plants Endogenous metabolite other families Microorganisms Sunscreen Phenols Polyphenols Cosmetic Research Disease Research Fields Cancer

Target:  

Free Radical Scavengers COX Reactive Oxygen Species (ROS) Apoptosis Ferroptosis Endogenous Metabolite

Gallic acid (3,4,5-Trihydroxybenzoic acid) is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2) . Gallic acid has various activities, such as antimicrobial, antioxidant, antimicrobial, anti-inflammatory, and anticance activities .
loading...
    loading...
View All Sizes
18
Gallic acid hydrate
Gallic acid hydrate
0 Images
18 Cited Publications
Cat. No.: HY-N0523A
CAS No.: 5995-86-8
Synonyms: 3,4,5-Trihydroxybenzoic acid hydrate
Category:  

Phenols Polyphenols Endogenous metabolite Disease Research Fields Inflammation/Immunology Cancer

Target:  

Free Radical Scavengers COX Reactive Oxygen Species (ROS) Apoptosis Ferroptosis Endogenous Metabolite

Gallic acid (3,4,5-Trihydroxybenzoic acid) hydrate is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2) . Gallic acid hydrate has various activities, such as antimicrobial, antioxidant, antimicrobial, anti-inflammatory, and anticance activities .
loading...
    loading...
View All Sizes
16
Xanthohumol
Xanthohumol
0 Images
16 Cited Publications
Cat. No.: HY-N1067
CAS No.: 6754-58-1
Category:  

Infection Flavonoids Chalcones Humulus lupulus L. Phenols Polyphenols Plants Moraceae Disease Research Fields

Target:  

COX Acyltransferase Apoptosis HSV CMV Influenza Virus

Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2 and cytomegalovirus (CMV).
loading...
    loading...
View All Sizes
16
Salicylic acid
Salicylic acid
0 Images
16 Cited Publications
Cat. No.: HY-B0167
CAS No.: 69-72-7
Synonyms: 2-Hydroxybenzoic acid
Category:  

Anti-aging Plants Endogenous metabolite Agricultural Research other families Monophenols Ketones, Aldehydes, Acids Phenols Phytohormone Disease Research Fields Inflammation/Immunology Cancer

Target:  

Environmental Pollutants Endogenous Metabolite COX Autophagy Apoptosis Mitophagy

Salicylic acid (2-Hydroxybenzoic acid) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation. Salicylic acid has blood-brain barrier permeability .
loading...
    loading...
View All Sizes
16
Sodium Salicylate
Sodium Salicylate
0 Images
16 Cited Publications
Cat. No.: HY-B0167A
CAS No.: 54-21-7
Synonyms: Salicylic acid sodium salt; 2-Hydroxybenzoic acid sodium salt
Category:  

Ketones, Aldehydes, Acids Asclepiadaceae Phenols Plants Periploca sepium Bunge Disease Research Fields Inflammation/Immunology Cancer

Target:  

Environmental Pollutants Ribosomal S6 Kinase (RSK) Endogenous Metabolite Apoptosis COX Autophagy NF-κB

Sodium Salicylate (Salicylic acid sodium salt) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation . Sodium Salicylate is also a S6K inhibitor.Sodium Salicylate is a NF-κB inhibitor that decreases inflammatory gene expression and improves repair in aged muscle .
loading...
    loading...
View All Sizes
14
Meloxicam
Meloxicam
0 Images
14 Cited Publications
Cat. No.: HY-B0261
CAS No.: 71125-38-7
Target:  

COX Autophagy Apoptosis MMP

Research Areas:  

Infection Neurological Disease Inflammation/Immunology Cancer

Meloxicam is a non-steroidal antiinflammatory agent that can pass through the blood-brain barrier, inhibits COX activity, with IC50s of 0.49 μM and 36.6 μM for COX-2 and COX-1, respectively.
loading...
    loading...
View All Sizes
10
Hydroxytyrosol
Hydroxytyrosol
0 Images
10 Cited Publications
Cat. No.: HY-N0570
CAS No.: 10597-60-1
Synonyms: DOPET; 3,4-Dihydroxyphenethyl alcohol; 3-Hydroxytyrosol
Category:  

Infection Canarium album (Lour.) Rauesch. Phenols Polyphenols Plants Burseraceae Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

Apoptosis Bacterial Reactive Oxygen Species (ROS) SARS-CoV Estrogen Receptor/ERR

Hydroxytyrosol (DOPET; 3,4-Dihydroxyphenethyl alcohol) is an orally active, blood-brain barrier-permeable multi-active compound with multiple effects including antibacterial, antioxidant, anti-platelet aggregation, and neuroprotective activities. Hydroxytyrosol not only inhibits the growth of Vibrio by increasing bacterial membrane permeability, but also interacts with DNA and mediates supercoiled DNA relaxation. Meanwhile, Hydroxytyrosol effectively reduces thrombosis and inhibits lipid oxidation by inhibiting COX activity and promoting vascular nitric oxide production. In terms of neuroprotection, Hydroxytyrosol significantly alleviates neuronal apoptosis and inflammatory responses by up-regulating the expression level of ERβ, thereby improving cognitive function in Alzheimer's disease models. Hydroxytyrosol has been widely used in scientific research related to Vibrio infection, arterial thrombosis, Alzheimer's disease and other related fields .
loading...
    loading...
View All Sizes
9
Ketoprofen
Ketoprofen
0 Images
9 Cited Publications
Cat. No.: HY-B0227
CAS No.: 22071-15-4
Synonyms: RP-19583
Target:  

COX

Research Areas:  

Metabolic Disease Inflammation/Immunology Cancer

Ketoprofen (RP-19583) is a non-steroidal anti-inflammatory agent. Ketoprofen can inhibits the activity of cyclooxygenase with IC50 values of 2 nM (COX-1) and 26 nM (COX-2). which is potential in the research of inflammation, immunology, and metabolic disease such as obesity .
loading...
    loading...
View All Sizes
9
Avicularin
Avicularin
0 Images
9 Cited Publications
Cat. No.: HY-N0222
CAS No.: 572-30-5
Category:  

Flavonols Flavonoids Phenols Polyphenols Plants Lauraceae Disease Research Fields Inflammation/Immunology Lindera aggregata (Sims) Kosterm.

Target:  

COX NF-κB PPAR ERK GLUT Apoptosis

Avicularin is an orally active flavonoid. Avicularin inhibits NF-κB (p65), COX-2 and PPAR-γ activities. Avicularin has anti-inflammatory, anti-infectious anti-allergic, anti-oxidant, hepatoprotective, and anti-tumor activities .
loading...
    loading...
View All Sizes
9
Jaceosidin
Jaceosidin
0 Images
9 Cited Publications
Cat. No.: HY-N0831
CAS No.: 18085-97-7
Category:  

Laburnum anagyroides Medic. Flavonoids Flavones Phenols Polyphenols Plants Compositae Disease Research Fields Inflammation/Immunology

Target:  

Bcl-2 Family COX Apoptosis

Jaceosidin is a flavonoid isolated from Artemisia vestita, induces apoptosis in cancer cells, activates Bax and down-regulates Mcl-1 and c-FLIP expression . Jaceosidin exhibits anti-cancer , anti-inflammatory activities, decreases leves of inflammatory markers, and suppresses COX-2 expression and NF-κB activation .
loading...
    loading...
View All Sizes
9
20(S)-Ginsenoside Rg3
20(S)-Ginsenoside Rg3
0 Images
9 Cited Publications
Cat. No.: HY-N0603
CAS No.: 14197-60-5
Synonyms: 20(S)-Propanaxadiol; S-ginsenoside Rg3
Category:  

Panax ginseng C. A. Meyer Triterpenes Neurological Disease Terpenoids Plants Endogenous metabolite Disease Research Fields Inflammation/Immunology Araliaceae

Target:  

Sodium Channel Potassium Channel NF-κB COX Amyloid-β Endogenous Metabolite

20(S)-Ginsenoside Rg3 is the main component of Panax ginseng C. A. Meyer. Ginsenoside Rg3 inhibits Na + and hKv1.4 channel with IC50s of 32.2±4.5 and 32.6±2.2 μM, respectively. 20(S)-Ginsenoside Rg3 also inhibits Aβ levels, NF-κB activity, and COX-2 expression.
loading...
    loading...
View All Sizes
8
Tryptanthrin
Tryptanthrin
0 Images
8 Cited Publications
Cat. No.: HY-N6607
CAS No.: 13220-57-0
Category:  

Alkaloids Polygonaceae Plants Disease Research Fields Inflammation/Immunology Polygonum tinctorium Ait. Indole Alkaloids

Target:  

Leukotriene Receptor NO Synthase NF-κB COX TNF Receptor Interleukin Related

Tryptanthrin is an indole quinazoline that could be an alkaloid from indigo-bearing plants. Tryptanthrin is a potent and orally active cellular Leukotriene (LT) biosynthesis inhibitor. Tryptanthrin has anticancer activity. Tryptanthrin suppresses the expression levels of NOS1, COX-2, and NF-κB and regulates the expression levels of IL-2, IL-10, and TNF-α .
loading...
    loading...
View All Sizes
8
Hederagenin
Hederagenin
0 Images
8 Cited Publications
Cat. No.: HY-N0256
CAS No.: 465-99-6
Category:  

Triterpenes Hedera nepalensis K. Koch var. sinensis (Tobl.) Rehd. Terpenoids Plants Disease Research Fields Araliaceae Cancer

Target:  

COX NF-κB E1/E2/E3 Enzyme

Hederagenin is a triterpenoid saponin with orally active and antitumor activity. Hederagenin can inhibit the expression of iNOS, COX-2, and NF-κB in cells induced by LPS stimulation. Hederagenin also increases ROS production in cancer cells, disrupts mitochondrial membrane potential, and induces apoptosis. Hederagenin also sensitizes cancer cells to Cisplatin (HY-17394) and Paclitaxel (HY-B0015), enhancing induced apoptosis. Hederagenin can also bind to SKP2, with KD = 67.9 μM. Hederagenin also has preventive potential against alcoholic liver injury .
loading...
    loading...
View All Sizes
7
Cornuside
Cornuside
0 Images
7 Cited Publications
Cat. No.: HY-N0631
CAS No.: 131189-57-6
Category:  

Cornaceae Iridoids Cornus officinalis Sieb. et Zucc. Terpenoids Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Free Radical Scavengers p38 MAPK NF-κB JNK Cholinesterase (ChE) Acyltransferase NO Synthase Interleukin Related TNF Receptor Prostaglandin Receptor ERK COX

Cornuside is an iridoid glycoside with anti-allergic, anti-inflammatory, and neuroprotective activities. Cornuside exerts anti-allergic activity by downregulating the p38 MAPK, JNK, and NF-κB signaling pathways, and inhibits IgE-mediated histamine release from mast cells. Cornuside improves cognitive impairment in mice by inhibiting BACE1 activity (IC50 = 55.84 μg/mL) and enhancing ChAT activity. Cornuside inhibits LPS (HY-D1056)-induced inflammatory mediators, including iNOS, COX-2, PGE2, TNF-α, IL-6, and IL-1β, by suppressing NF-κB activation .
loading...
    loading...
View All Sizes
6
Niflumic acid
Niflumic acid
0 Images
6 Cited Publications
Cat. No.: HY-B0493
CAS No.: 4394-00-7
Target:  

Chloride Channel COX

Research Areas:  

Inflammation/Immunology Cancer

Niflumic acid is a calcium-activated chloride channel blocker and COX-2 inhibitor with the IC50 value of 100 nM. Niflumic acid induces apoptosis through caspase-8/Bid/Bax pathway in lung cancer cells. Niflumic acide exhibits anti-tumor activity by affecting the expression of ERK1/2 and the activity of MMP2 and MMP9. Niflumic acid has orally bioactivity. Niflumic acid acts on rheumatoid arthritis .
loading...
    loading...
View All Sizes
Assay Types