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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
28 Results for "
Carboxylesterase (CES)
" in MedChemExpress (MCE) Product Catalog:
Products (28)
28 Results for "Carboxylesterase (CES)" in MCE Product Catalog:
3
1
1 Cited Publications
Cat. No.: HY-124700
CAS No.: 1966129-74-7
Research Areas:
LYPLAL1-IN-1 (compound 11) is a selective, covalent, and irreversible inhibitor of the lysophospholipase-like enzyme LYPLAL1 (IC50 = 6 nM). LYPLAL1-IN-1 shows selectivity against other serine hydrolases such as carboxylesterase CES1 (IC50 > 50 μM for CES1). LYPLAL1-IN-1 inhibits the depalmitoylation function of LYPLAL1, blocking its depalmitoylation modification of cyclic GMP-AMP synthase (cGAS), thereby promoting cGAS dimerization and activation, and initiating the cGAS-STING pathway-mediated innate immune response. LYPLAL1-IN-1 can enhance DNA-induced type I interferon production, upregulate PD-L1 expression in tumor cells, and promote the accumulation of tumor-infiltrating CD8 + T cells, with the core function of strengthening the anti-tumor immune response. LYPLAL1-IN-1 is primarily used in tumor immunology research, especially in combination with PD-1/PD-L1 inhibitors .
Target:
Carboxylesterase (CES) Free Fatty Acid Receptor Reactive Oxygen Species (ROS) Mitochondrial Metabolism Ferroptosis Apoptosis
Research Areas:
GR148672X is an inhibitor of carboxylesterase 1 (CES1) and hepatic microsomal triglyceride hydrolase (TGH). GR148672X blocks the catalytic activity of CES1, impairs the functions of triglyceride and cholesteryl ester lipase, reduces triglyceride mobilization and secretion, and decreases apolipoprotein B-100 secretion in primary rat hepatocytes. Under low-glucose conditions, GR148672X inhibits the survival of colorectal cancer cells by reducing free fatty acid availability, inducing toxic triglyceride accumulation, ROS production, mitochondrial damage, ferroptosis and apoptosis. GR148672X can be used in studies related to colorectal cancer and atherosclerosis .
Cat. No.: HY-N10686
CAS No.: 61077-78-9
Target:
Research Areas:
WWL229 is a selective inhibitor of carboxylesterase 3 (CES3) with an IC50 1.94 μM. WWL229 attenuates LPS (HY-D1056)-induced pro-inflammatory cytokine mRNA levels, inhibits lipolysis and adipose thermogenesis, impairs mitochondrial function, and promotes lipid storage. WWL229 can be used for the research of obesity, insulin resistance, type 2 diabetes, and lung inflammation .
Cat. No.: HY-W341421
CAS No.: 4346-15-0
Cat. No.: HY-E70599
Target:
Research Areas:
Human CES2 Enzyme is a carboxylesterase involved in drug metabolism and lipid homeostasis. Human CES2 Enzyme hydrolyzes triglycerides, cholesteryl esters and retinyl esters to regulate lipid metabolism and energy homeostasis. Human CES2 Enzyme improves glucose tolerance and insulin sensitivity, reduces hepatic lipid accumulation, alleviates white adipose tissue steatitis, decreases plasma cholesterol levels, and reduces body weight and white adipose tissue weight. Human CES2 Enzyme can be used in the research of metabolic syndrome .
Cat. No.: HY-176841
CAS No.: 648894-93-3
Target:
Research Areas:
Carboxylesterase-IN-5 (Compound 2e) is an irreversible and competitive Carboxylesterase (CES) inhibitor with an IC50 of 21.7 nM for porcine liver CES. Carboxylesterase-IN-5 can be used for hypocholesterolemia research .
Target:
Research Areas:
1-Methylisatin is a potent and selective CE (carboxylesterases) inhibitor, with Kis of 38.2 and 5.38 μM for hiCE and hCE1, respectively. 1-Methylisatin interacts with Hb (human adult hemoglobin) by hydrophobic binding and electrostatic attraction. 1-Methylisatin can be used in the study of regulation of agent metabolism in vivo .
Cat. No.: HY-N1951R
CAS No.: 27210-57-7
Synonyms: Rosmariquinone (Standard)
Target:
Research Areas:
Dibromsalicil (Compound 31) is a carboxylesterase (CES) inhibitor with activity of 72.7 nM against hiCE (human intestinal carboxylesterase) and 53.5 nM against rCE (rabbit liver carboxylesterase). Dibromsalicil has almost no activity against hCE1 (human liver carboxylesterase) and cholinesterase .
Cat. No.: HY-147331
CAS No.: 208720-71-2
Target:
Research Areas:
Oseltamivir acid methyl ester is a precursor form of the neuraminidase inhibitor and antiviral oseltamivir acid. Oseltamivir acid methyl ester is converted to oseltamivir acid by carboxylesterase 1 (CES1) .
Cat. No.: HY-162502
CAS No.: 304882-43-7
Target:
Research Areas:
WZU-13 is an inhibitor for Carboxylesterase (CES). WZU-13 inhibits 77% CES activity at a dose of 100 μM .
Cat. No.: HY-176465
CAS No.: 3037959-47-7
Target:
Research Areas:
CES2A-IN-3 (Compound 9d) is a potent serine-targeting covalent human carboxylesterase 2A (hCES2A) inhibitor with an IC50 value of 0.12 nM. CES2A-IN-3 is promising for research of diarrhea and ulcerative colitis .
Cat. No.: HY-147331A
CAS No.: 208720-78-9
Target:
Research Areas:
Oseltamivir acid methyl ester hydrochloride is a precursor form of the neuraminidase inhibitor and antiviral oseltamivir acid. Oseltamivir acid methyl ester hydrochloride is converted to oseltamivir acid by carboxylesterase 1 (CES1) .
Cat. No.: HY-P76193
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CES2; Carboxylesterase 2 (Intestine, Liver); Carboxylesterase 2; Cocaine Esterase; CE-2; Intestinal Carboxylesterase; Liver Carboxylesterase-2; ICE; Carboxylic Ester Hydrolase; CES2A1; PCE-2; Methylumbelliferyl-Acetate Deacetylase 2; HCE-2
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P76192A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CES2; Carboxylesterase 2 (Intestine, Liver); Carboxylesterase 2; Cocaine Esterase; CE-2; Intestinal Carboxylesterase; Liver Carboxylesterase-2; ICE; Carboxylic Ester Hydrolase; CES2A1; PCE-2; Methylumbelliferyl-Acetate Deacetylase 2; HCE-2
Species:
Human
Source:
HEK293
Cat. No.: HY-P76192
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CES2; Carboxylesterase 2 (Intestine, Liver); Carboxylesterase 2; Cocaine Esterase; CE-2; Intestinal Carboxylesterase; Liver Carboxylesterase-2; ICE; Carboxylic Ester Hydrolase; CES2A1; PCE-2; Methylumbelliferyl-Acetate Deacetylase 2; HCE-2
Species:
Human
Source:
HEK293
Cat. No.: HY-P7730
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CES1; Cocaine Carboxylesterase; Carboxylesterase 1; Retinyl Ester Hydrolase; HMSE; Serine Esterase 1; CES2; CES1A1; SES1; CES1A2; CEH; Egasyn; HMSE1; HCE-1; Carboxylesterase 1 (Monocyte/Macrophage Serine Esterase 1); ACAT; Human Monocyte/Macrophage Serine
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
