1338575-28-2
Chemical Structure
WWL229
- CAS. Nr.: 1338575-28-2
- Formula:C16H22N2O5
- Molecular Weight:322.36
IUPAC Name: 4-nitrophenyl 2-(3-methoxypropyl)piperidine-1-carboxylate
InChIKey: XVBRVSAGMWRVCK-UHFFFAOYSA-N
SMILES: O=C(N1CCCCC1CCCOC)OC2=CC=C(C=C2)[N+]([O-])=O
Biological Activity: WWL229 is a selective inhibitor of carboxylesterase 3 (CES3) with an IC50 1.94 μM. WWL229 attenuates LPS (HY-D1056)-induced pro-inflammatory cytokine mRNA levels, inhibits lipolysis and adipose thermogenesis, impairs mitochondrial function, and promotes lipid storage. WWL229 can be used for the research of obesity, insulin resistance, type 2 diabetes, and lung inflammation[1][2][3][4][5][6].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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WWL229 | 99.49% | WWL229 is a selective inhibitor of carboxylesterase 3 (CES3) with an IC50 1.94 μM. WWL229 attenuates LPS (HY-D1056)-induced pro-inflammatory cytokine mRNA levels, inhibits lipolysis and adipose thermogenesis, impairs mitochondrial function, and promotes lipid storage. WWL229 can be used for the research of obesity, insulin resistance, type 2 diabetes, and lung inflammation. | ||||||||||||||||||||
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- [1]. Scheaffer HL, et al. Inactivation of CES1 Blocks Prostaglandin D2 Glyceryl Ester Catabolism in Monocytes/Macrophages and Enhances Its Anti-inflammatory Effects, Whereas the Pro-inflammatory Effects of Prostaglandin E2 Glyceryl Ester Are Attenuated. ACS Omega. 2020;5(45):29177-29188. Published 2020 Nov 3. [Content Brief]
- [2]. Yang L, et al. A Unique Role of Carboxylesterase 3 (Ces3) in β-Adrenergic Signaling-Stimulated Thermogenesis. Diabetes. 2019;68(6):1178-1196. [Content Brief]
- [3]. Szafran BN, et al. Carboxylesterase 1d Inactivation Augments Lung Inflammation in Mice. ACS Pharmacol Transl Sci. 2022 Sep 12;5(10):919-931. [Content Brief]
- [4]. Borazjani A, et al. Thromboxane A2 synthase is an off target of the CES1 small-molecule inhibitor WWL113. Prostaglandins Other Lipid Mediat. Published online April 3, 2026. [Content Brief]
- [5]. Dominguez E, et al. Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes. Nat Chem Biol. 2014;10(2):113-121. [Content Brief]
- [6]. Taira A, et al. Carboxylesterase 1d-mediated aglycone recognition is crucial for substrate processing and allosteric activation of endo-α-mannosidase in the endoplasmic reticulum. Bioorg Med Chem. 2026;134:118547. [Content Brief]
Keywords
